Results 31 to 40 of about 10,371 (142)

The Peyer's patch mononuclear phagocyte system at steady state and during infection [PDF]

, 2017
The gut represents a potential entry site for a wide range of pathogens including protozoa, bacteria, viruses, or fungi. Consequently, it is protected by one of the largest and most diversified population of immune cells of the body.
Bonnardel, Johnny, Da Silva, Clement, Gorvel, Jean-Pierre, Lelouard, Hugues, Wagner, Camille   +4 more
core   +11 more sources

Preclinical characterization of the novel anti-SIRPα antibody BR105 that targets the myeloid immune checkpoint

Journal for ImmunoTherapy of Cancer, 2022
Background The CD47-SIRPα pathway acts as an important myeloid cell immune checkpoint and targeting the CD47/SIRPα axis represents a promising strategy to promote antitumor immunity.
Juan Chen, Gang Chen, Na Li, Yao Chen, Lei Nie, Zhen-Hua Wu, Xiao-Feng Mei, Xiao-Ze Wang, Ting-Ting Guo, Mei-Zhu Jiang, Ji-Teng Wang, Hai-Bin Wang   +11 more
doaj   +1 more source

Functional characterization of the selective pan-allele anti-SIRPα antibody ADU-1805 that blocks the SIRPα–CD47 innate immune checkpoint

Journal for ImmunoTherapy of Cancer, 2019
Background Accumulating preclinical data indicate that targeting the SIRPα/CD47 axis alone or in combination with existing targeted therapies or immune checkpoint inhibitors enhances tumor rejection.
Erik Voets, Marc Paradé, David Lutje Hulsik, Sanne Spijkers, Wout Janssen, Joost Rens, Inge Reinieren-Beeren, Gilbert van den Tillaart, Sander van Duijnhoven, Lilian Driessen, Maurice Habraken, Peter van Zandvoort, Joost Kreijtz, Paul Vink, Andrea van Elsas, Hans van Eenennaam   +15 more
doaj   +1 more source

Modulation of Signal Regulatory Protein α (SIRPα) by Plasmodium Antigenic Extract: A Preliminary In Vitro Study on Peripheral Blood Mononuclear Cells

Microorganisms, 2022
Signal regulatory protein α (SIRPα) is an immunoreceptor expressed in myeloid innate immune cells that signals for inhibition of both phagocytosis and inflammatory response.
Priscilla da Costa Martins, Hugo Amorim dos Santos de Souza, Carolina Moreira Blanco, Luana Santos-de-Oliveira, Lilian Rose Pratt-Riccio, Cláudio Tadeu Daniel-Ribeiro, Paulo Renato Rivas Totino   +6 more
doaj   +1 more source

Hepatitis C virus infection and related liver disease: the quest for the best animal model [PDF]

, 2013
Hepatitis C virus (HCV) is a major cause of cirrhosis and hepatocellular carcinoma (HCC) making the virus the most common cause of liver failure and transplantation.
Baumert, Thomas F, Mailly, Laurent, Meuleman, Philip, Robinet, Eric, Zeisel, Mirjam   +4 more
core   +3 more sources

Deletion of SIRPα (signal regulatory protein-α) promotes phagocytic clearance of myelin debris in Wallerian degeneration, axon regeneration, and recovery from nerve injury

Journal of Neuroinflammation, 2019
Background Recovery of function from traumatic nerve injury depends on the ability of severed axons to grow/regenerate back to their target tissues. This is achieved by successfully crossing the lesion site where physical impact severed axons, determined
Gerard Elberg, Sigal Liraz-Zaltsman, Fanny Reichert, Takashi Matozaki, Michael Tal, Shlomo Rotshenker   +5 more
doaj   +1 more source

Protein-tyrosine Phosphatase Shp2 Positively Regulates Macrophage Oxidative Burst [PDF]

, 2014
Macrophages are vital to innate immunity and express pattern recognition receptors and integrins for the rapid detection of invading pathogens. Stimulation of Dectin-1 and complement receptor 3 (CR3) activates Erk- and Akt-dependent production of ...
Chan, Rebecca J., Feng, Gen-Sheng, Goodwin, Charles B., Hanenberg, Helmut, Li, Xing Jun, Matozaki, Takashi, Nabinger, Sarah C., Ohnishi, Hiroshi, Richine, Briana M., Yang, Zhenyun   +9 more
core   +2 more sources

Long-term leukocyte reconstitution in NSG mice transplanted with human cord blood hematopoietic stem and progenitor cells [PDF]

, 1944
Background Humanized mice (hu mice) are based on the transplantation of hematopoietic stem and progenitor cells into immunodeficient mice and have become important pre-clinical models for biomedical research.
Audigé, Annette, Rochat, Mary-Aude, Li, Duo, Ivic, Sandra, Fahrny, Audrey, Muller, Christina K S, Gers-Huber, Gustavo, Myburgh, Renier, Bredl, Simon, Schlaepfer, Erika, Scherrer, Alexandra U, Kuster, Stefan P, Speck, Roberto F   +12 more
core   +3 more sources

Targeting the CD47-SIRPα Axis: Present Therapies and the Future for Cutaneous T-cell Lymphoma

Cells, 2022
The loss of CD47 on aging cells serves as a signal to macrophages to eliminate the target. Therefore, CD47 is a “do-not-eat-me” sign preventing macrophagal phagocytosis via interaction with its ligand SIRPα. Malignant lymphocytes of mycosis fungoides and
Amy Xiao, Oleg E. Akilov
doaj   +1 more source

Dendritic cell subsets in the intestinal lamina propria: ontogeny and function [PDF]

, 2013
The intestinal mucosa is exposed to large amounts of foreign antigen (Ag) derived from commensal bacteria, dietary Ags, and intestinal pathogens. Dendritic cells (DCs) are believed to be involved in the induction of tolerance to harmless Ags and in ...
Agace, Agace, Agace, Aliberti, Anjuere, Annacker, Bachem, Bachem, Bain, Banchereau, Bedoui, Bogunovic, Carter, Cebula, Cerovic, Chervonsky, Coombes, Crozat, Cruickshank, del Rio, del Rio, Denning, Diehl, Edelson, Edelson, Farache, Forster, Fujimoto, Ginhoux, Greter, Hadis, Halle, Hammerschmidt, Haniffa, Hildner, Hoshi, Ichikawa, Iwata, Jackson, Jaensson, Jaensson-Gyllenback, Jang, Johansson-Lindbom, Johansson-Lindbom, Jones, Jongbloed, Kinnebrew, Kobayashi, Kusunoki, Lewis, Liu, Macpherson, Maynard, McDole, Merad, Miller, Milling, Molenaar, Mucida, Naik, Naik, Niess, Onai, Persson, Poulin, Poulin, Rescigno, Rivollier, Sathaliyawala, Schlitzer, Schulz, Scott, Siddiqui, Sun, Svensson, Tamoutounour, Travis, Uematsu, Uematsu, Vallon-Eberhard, Varol, Vremec, Weiss, Worbs, Wu, Zeng, Zhan, Zigmond   +87 more
core   +1 more source