Results 41 to 50 of about 10,371 (142)

A hitchhiker's guide to myeloid cell subsets: practical implementation of a novel mononuclear phagocyte classification system [PDF]

, 2015
The classification of mononuclear phagocytes as either dendritic cells or macrophages has been mainly based on morphology, the expression of surface markers, and assumed functional specialization.
Adams, Ajami, Ajami, Bachem, Bachem, Bain, Bain, Balan, Becker, Benson, Bogunovic, Breton, Caton, Caux, Cheong, Chorro, Chou, Cisse, Contreras, Coombes, Crozat, Crozat, Crozat, Desch, Diao, Durand, Edelson, Epelman, Gao, Gatto, Gautier, Geissmann, Geurtsvankessel, Ghosh, Ginhoux, Ginhoux, Ginhoux, Gomez Perdiguero, Grajales-Reyes, Guilliams, Guilliams, Guilliams, Guilliams, Guilliams, Guilliams, Gurka, Hacker, Hashimoto, Helft, Hettinger, Hildner, Hoeffel, Hoeffel, Inaba, Jackson, Jaitin, Jakubzick, Jang, Janssen, Jha, Karsunky, Kashiwada, Kuipers, Lavin, Lee, Lewis, McKenna, Merad, Miller, Molawi, Murray, Naik, Naik, Naik, Ohl, Onai, Onai, Palucka, Persson, Plantinga, Poltorak, Poulin, Pulendran, Randolph, Reynolds, Robbins, Sallusto, Salomon, Satpathy, Saunders, Schiavoni, Schlitzer, Schlitzer, Schraml, Schulz, Scott, Serbina, Shalek, Siddiqui, Sun, Suzuki, Swirski, Tailor, Tamoutounour, Tamoutounour, Tamura, Tussiwand, van Furth, van Furth, Varol, Varol, Varol, Vu Manh, Vu Manh, Vu Manh, Waskow, Wimmers, Wu, Xu, Xue, Yamasaki, Yona, Yona, Zigmond   +123 more
core   +6 more sources

Skap2 is required for β2 integrin-mediated neutrophil recruitment and functions. [PDF]

, 2017
Integrin activation is required for neutrophil functions. Impaired integrin activation on neutrophils is the hallmark of leukocyte adhesion deficiency (LAD) syndrome in humans, characterized by impaired leukocyte recruitment and recurrent infections. The
Bardel, Bernadette, Block, Helena, Bokemeyer, Arne, Boras, Mark, Heitplatz, Barbara, Kliche, Stefanie, Lowell, Clifford, Reinhold, Annegret, Rossaint, Jan, Van Marck, Veerle, Volmering, Stephanie, Zarbock, Alexander   +11 more
core   +2 more sources

SIRPα Controls the Activity of the Phagocyte NADPH Oxidase by Restricting the Expression of gp91phox

Cell Reports, 2012
The phagocyte NADPH oxidase mediates oxidative microbial killing in granulocytes and macrophages. However, because the reactive oxygen species produced by the NADPH oxidase can also be toxic to the host, it is essential to control its activity. Little is
Ellen M. van Beek, Julian Alvarez Zarate, Robin van Bruggen, Karin Schornagel, Anton T.J. Tool, Takashi Matozaki, Georg Kraal, Dirk Roos, Timo K. van den Berg   +8 more
doaj   +1 more source

Microglial SIRPα regulates the emergence of CD11c+ microglia and demyelination damage in white matter

eLife, 2019
A characteristic subset of microglia expressing CD11c appears in response to brain damage. However, the functional role of CD11c+ microglia, as well as the mechanism of its induction, are poorly understood.
Miho Sato-Hashimoto, Tomomi Nozu, Riho Toriba, Ayano Horikoshi, Miho Akaike, Kyoko Kawamoto, Ayaka Hirose, Yuriko Hayashi, Hiromi Nagai, Wakana Shimizu, Ayaka Saiki, Tatsuya Ishikawa, Ruwaida Elhanbly, Takenori Kotani, Yoji Murata, Yasuyuki Saito, Masae Naruse, Koji Shibasaki, Per-Arne Oldenborg, Steffen Jung, Takashi Matozaki, Yugo Fukazawa, Hiroshi Ohnishi   +22 more
doaj   +1 more source

Duality of β-glucan microparticles: antigen carrier and immunostimulants [PDF]

, 2016
Designing efficient recombinant mucosal vaccines against enteric diseases is still a major challenge. Mucosal delivery of recombinant vaccines requires encapsulation in potent immunostimulatory particles to induce an efficient immune response. This paper
Baert, Kim, Cox, Eric, De Geest, Bruno, De Greve, Henri, Devriendt, Bert   +4 more
core   +2 more sources

The matricellular protein TSP1 promotes human and mouse endothelial cell senescence through CD47 and Nox1. [PDF]

, 2017
Senescent cells withdraw from the cell cycle and do not proliferate. The prevalence of senescent compared to normally functioning parenchymal cells increases with age, impairing tissue and organ homeostasis. A contentious principle governing this process
Al Ghouleh, I, Amaral, JH, Attaran, S, Bienes-Martinez, R, Cifuentes-Pagano, E, Gladwin, MT, Isenberg, JS, Knupp, HE, Meijles, DN, Nouraie, SM, Novelli, EM, Pagano, PJ, Rojas, MM, Sahoo, S, Sembrat, JC   +14 more
core   +1 more source

Effects of a humanized CD47 antibody and recombinant SIRPα proteins on triple negative breast carcinoma stem cells

Frontiers in Cell and Developmental Biology
Signal regulatory protein-α (SIRPα, SHPS-1, CD172a) expressed on myeloid cells transmits inhibitory signals when it engages its counter-receptor CD47 on an adjacent cell.
Sukhbir Kaur, Bianca Reginauld, Sam Razjooyan, Trung Phi, Satya P. Singh, Thomas J. Meyer, Margaret C. Cam, David D. Roberts   +7 more
doaj   +1 more source

Notch Signaling Modulates Macrophage Polarization and Phagocytosis Through Direct Suppression of Signal Regulatory Protein α Expression

Frontiers in Immunology, 2018
The Notch pathway plays critical roles in the development and functional modulation of myeloid cells. Previous studies have demonstrated that Notch activation promotes M1 polarization and phagocytosis of macrophages; however, the downstream molecular ...
Yan Lin, Yan Lin, Yan Lin, Jun-Long Zhao, Jun-Long Zhao, Qi-Jun Zheng, Xun Jiang, Jiao Tian, Shi-Qian Liang, Hong-Wei Guo, Hong-Yan Qin, Ying-Min Liang, Hua Han, Hua Han   +13 more
doaj   +1 more source

Targeting CD47/SIRPα as a therapeutic strategy, where we are and where we are headed

Biomarker Research, 2022
Immunotherapy using PD-1 and CTLA4 inhibitors to stimulate T cell immunity has achieved significant clinical success. However, only a portion of patients benefit from T cell-based immunotherapy.
Tailong Qu, Baiyong Li, Yifei Wang
doaj   +1 more source

An in vitro model to assess the immunosuppressive effect of tick saliva on the mobilization of inflammatory monocyte-derived cells [PDF]

, 2015
Tick-borne pathogens cause potent infections. These pathogens benefit from molecules contained in tick saliva that have evolved to modulate host innate and adaptive immune responses.
A Frauenschuh, A Lanzavecchia, A Martin-Fontecha, A Sa-Nunes, A Skallova, Carinne Puech, CJ Oliveira, D Werling, DL Borjesson, Dominique Martinez, E Hodzic, E Shklovskaya, ES Trombetta, F Sallusto, GJ Randolph, GJ Randolph, GJ Randolph, GP Brooke, I Vancova, JC Hope, JM Ribeiro, JW Hovius, JW Hovius, M Deruaz, M Epardaud, M Guilliams, M Lopez-Bravo, Mathieu Epardaud, Nathalie Vachiery, PA Nuttall, Patricia Cavelier, R Garg, RM Steinman, Rosalie Aprelon, S Ochiai, SG Preston, Thierry Lefrançois, Valérie Rodrigues   +37 more
core   +4 more sources