Results 71 to 80 of about 10,371 (142)

Primary Phagocytosis of Neurons by Inflamed Microglia: Potential Roles in Neurodegeneration [PDF]

, 2012
Microglial phagocytosis of dead or dying neurons can be beneficial by preventing secondary necrosis and release of pro-inflammatory intracellular components.
Jonas J. Neher, Urte Neniskyte, Guy C. Brown   +2 more
core   +2 more sources

Extracellular Matrix Protein Tenascin C Increases Phagocytosis Mediated by CD47 Loss of Function in Glioblastoma. [PDF]

, 2019
Glioblastomas (GBM) are highly infiltrated by myeloid-derived innate immune cells that contribute to the immunosuppressive nature of the brain tumor microenvironment (TME).
Gao, Peisong, Lal, Bachchu, Laterra, John, Lee, Richard S, Li, Jian Jian, Liu, Senquan, Lopez-Bertoni, Hernando, Ma, Ding, Wang, Shuyan, Wei, Shuang, Wilson, Mary Ann, Xia, Shuli, Ying, Mingyao, Zhan, Daqian, Zhang, Hao   +14 more
core   +2 more sources

IFNAR1-Signalling Obstructs ICOS-mediated Humoral Immunity during Non-lethal Blood-Stage Plasmodium Infection [PDF]

, 2016
Funding: This work was funded by a Career Development Fellowship (1028634) and a project grant (GRNT1028641) awarded to AHa by the Australian National Health & Medical Research Council (NHMRC).
A Haque, A Haque, A Haque, A Le Bon, A Pratama, A Pratama, A Sabchareon, AJ McAdam, Andreas Hutloff, Ashraful Haque, BC Rocha, Bryce S. Thomas, C Aucan, C Li, C Shin, C Voisine, CC Kim, CG Matar, Christian R. Engwerda, CL Edwards, D Baumjohann, D Liu, D Perez-Mazliah, D Yu, DJ Wikenheiser, DK Raj, DS Karunarathne, DS Khoury, EA Ball, EG Findlay, ES Coro, Fabian de Labastida Rivera, Fernando Souza-Fonseca-Guimaraes, FH Amante, FH Amante, Fiona H. Amante, G Jego, G Suss, G Trinchieri, Geoffrey R. Hill, H Akiba, H Cucak, H Ueno, H Veiga-Fernandes, H Xu, HC van der Heyde, Ismail Sebina, J Banchereau, J Langhorne, J Li, JA Harker, JA Harker, JC Hall, JL Grun, JP Ray, JP Weber, JW Leavenworth, K Warnatz, Kylie R. James, L Beattie, LB Ivashkiv, Lily G. Fogg, Lynette Beattie, Marcela Montes de Oca, Marcela Montes de Oca, Maria M. Mota, Mark J. Smyth, Megan S. F. Soon, MJ Boyle, MT White, N Obeng-Adjei, NS Butler, O Dienz, Paul J. Hertzog, PF Yong, RA Seder, RA Zander, S Cohen, S Crotty, S Nakayamada, S Pichyangkul, S Portugal, S Sharma, Shannon E. Best, T von der Weid, V Ryg-Cornejo, YS Choi, YS Choi, YS Choi, Z Su   +89 more
core   +5 more sources

Targeting the myeloid checkpoint receptor SIRPα potentiates innate and adaptive immune responses to promote anti-tumor activity

Journal of Hematology & Oncology, 2020
Background Signal regulatory protein α (SIRPα) is a myeloid-lineage inhibitory receptor that restricts innate immunity through engagement of its cell surface ligand CD47.
Tracy C. Kuo, Amy Chen, Ons Harrabi, Jonathan T. Sockolosky, Anli Zhang, Emma Sangalang, Laura V. Doyle, Steven E. Kauder, Danielle Fontaine, Sangeetha Bollini, Bora Han, Yang-Xin Fu, Janet Sim, Jaume Pons, Hong I. Wan   +14 more
doaj   +1 more source

Insights into Thymus Development and Viral Thymic Infections [PDF]

, 2019
T-cell development in the thymus is a complex and highly regulated process, involving a wide variety of cells and molecules which orchestrate thymocyte maturation into either CD4+ or CD8+ single-positive (SP) T cells.
Albano, F., Arcucci, A., Avagliano, A., Caiazza, C., Donato, G., Fiume, G., Iaccino, E., Mallardo, M., Mimmi, S., Pagliara, V., Palmieri, C., Quinto, I., Renna, M., Vecchio, E.   +13 more
core   +1 more source

The serum opsonin L-ficolin is detected in lungs of human transplant recipients following fungal infections and modulates inflammation and killing of Aspergillus fumigatus. [PDF]

, 2015
BACKGROUND: Invasive aspergillosis (IA) is a life-threatening systemic fungal infection in immunocompromised individuals that is caused by Aspergillus fumigatus. The human serum opsonin, L-ficolin, has been observed to recognize A.
Abdolrasouli, A, Armstrong-James, D, Bidula, S, Reed, A, Schelenz, S, Sexton, DW, Shah, A   +6 more
core   +2 more sources

Suppression of ILC2 differentiation from committed T cell precursors by E protein transcription factors [PDF]

, 2019
Current models propose that group 2 innate lymphoid cells (ILC2s) are generated in the bone marrow. Here, we demonstrate that subsets of these cells can differentiate from multipotent progenitors and committed T cell precursors in the thymus, both in ...
Adrianto, Indra, Alberola-Ila, Jose, Bajana, Sandra, Colonna, Marco, Georgescu, Constantin, Peng, Vincent, Qian, Liangyue, Sun, Xiao-Hong, Wang, Hong-Cheng, Wren, Jonathan D   +9 more
core   +1 more source

CCR2⁺CD103⁻ intestinal dendritic cells develop from DC-committed precursors and induce interleukin-17 production by T cells [PDF]

, 2014
The identification of intestinal macrophages (m phi s) and dendritic cells (DCs) is a matter of intense debate. Although CD103(+) mononuclear phagocytes (MPs) appear to be genuine DCs, the nature and origins of CD103(-) MPs remain controversial.
Agace, William,, Bain, C C, Guilliams, M, Kotarsky, Knut,, Lambrecht, B N, Luda, Katarzyna,, Lund University., Milling, S Wf, Mowat, Allan,, Persson, Emma,, Scott, C L, Sichien, D, Wright, P B   +12 more
core   +3 more sources

Biomimetic Nano‐Degrader Based CD47‐SIRPα Immune Checkpoint Inhibition Promotes Macrophage Efferocytosis for Cardiac Repair

Advanced Science
CD47‐SIRPα axis is an immunotherapeutic target in tumor therapy. However, current monoclonal antibody targeting CD47‐SIRPα axis is associated with on‐target off‐tumor and antigen sink effects, which significantly limit its potential clinical application.
Jinfeng Gao, Zhiqing Pang, Qiaozi Wang, Yiwen Tan, Qiyu Li, Haipeng Tan, Jing Chen, Wusiman Yakufu, Zhengmin Wang, Hongbo Yang, Jinyan Zhang, Dili Sun, Xueyi Weng, Qibing Wang, Juying Qian, Yanan Song, Zheyong Huang, Junbo Ge   +17 more
doaj   +1 more source

The expression of signal regulatory protein alpha (SIRPα) in periodontal cells and tissue

Acta Odontologica Scandinavica
Signal regulatory protein alpha (SIRPα) is mainly expressed by cells of myeloid origin. This membrane glycoprotein is shown to be involved in regulation of different inflammatory conditions, such as colitis and arthritis.
Cecilia Koskinen Holm, Sara Rosendahl , Per-Arne Oldenborg , Pernilla Lundberg   +3 more
doaj   +1 more source