Results 71 to 80 of about 8,132 (145)

Redefining CHI3L1: Therapeutic Opportunities at the Crossroads of Immune Suppression and Disease Progression

Medicinal Research Reviews, Volume 46, Issue 6, Page 1897-1921, November 2026.
ABSTRACT Chitinase‐3‐like‐1 (CHI3L1, also known as YKL‐40) has been recognized as a biomarker of inflammation and tissue remodeling and has now emerged as a pseudoenzymatic immune checkpoint. Recent structural, immunological, and translational studies redefine it as an active regulator of immune suppression rather than a passive disease marker. Despite
Kirti Upmanyu, Saurabh Upadhyay, Moustafa T. Gabr   +2 more
wiley   +1 more source

Hormonal replacement therapy in postmenopausal women ≥50 years is associated with the incidence of glaucoma: Evidence from 6576 females in Finland

Acta Ophthalmologica, Volume 104, Issue 7, Page 742-749, November 2026.
Abstract Purpose Hormonal replacement therapy (HRT) in postmenopausal women appears to affect glaucoma risk, but findings are inconsistent. We aimed to explore whether the use of postmenopausal HRT plays a role in glaucoma development in Finland. Methods The main outcome variable was glaucoma incidence measured by initiation of special reimbursement ...
Sirpa Loukovaara, Jari Haukka
wiley   +1 more source

Mentors' Experiences of Nursing Students' Peer Learning in Clinical Practice: A Systematic Review of Qualitative Studies

Journal of Advanced Nursing, Volume 82, Issue 11, Page 9507-9526, November 2026.
ABSTRACT Aim To synthesise the best available evidence on mentors' experiences in mentoring nursing students during peer learning clinical practice. Design A systematic review of qualitative studies. Methods Qualitative or mixed‐methods (with a qualitative component) studies that met the inclusion criteria based on the phenomenon of interest were ...
Sanna Kulojärvi, Sara Palander, Toni Haapa, Erika Jarva, Agostinho A. C. Araújo, Kristina Mikkonen, Jonna Juntunen   +6 more
wiley   +1 more source

Effectiveness of Social Robots in Relieving Children's and Adolescents' Anxiety, Pain, Fear and Stress in Perioperative Nursing: A Systematic Review and Meta‐Analysis

Journal of Clinical Nursing, Volume 35, Issue 11, Page 4725-4742, November 2026.
ABSTRACT Aim To assess how social robots impact anxiety, pain, fear and stress in children and adolescents during perioperative nursing. Design A systematic review and meta‐analysis of randomised controlled trials and quasi‐experimental studies. Methods Following Joanna Briggs Institute guidelines, eligible studies included participants under 21 ...
Miia Kauppinen, Aku Forsman, Heli Kerimaa, Anna‐Kaija Palomaa, Mervi Hakala, Shingo Ueki, Tarja Pölkki   +6 more
wiley   +1 more source

Targeting CD47-SIRPα axis for Hodgkin and non-Hodgkin lymphoma immunotherapy

Genes and Diseases
The interaction between cluster of differentiation 47 (CD47) and signal regulatory protein α (SIRPα) protects healthy cells from macrophage attack, which is crucial for maintaining immune homeostasis.
Pengcheng Zhao, Longyan Xie, Lei Yu, Ping Wang   +3 more
doaj   +1 more source

From Cell‐Derived Vesicles to Hybrid Nanovectors: Biological Membranes as Functional Blueprints for Gene Delivery

Advanced Healthcare Materials, Volume 15, Issue 37, 9 October 2026.
Biologically derived and hybrid nonviral nanovectors are examined as distinct but convergent design approaches. Integrating synthetic components with biologically functionalized membranes allows efficient interactions with complex cellular environments.
Clara Baldari, Claudia Leone, Gabriella Leccese, Claudia De Stradis, Alessandra Invidia, Concetta Quintarelli, Biagio De Angelis, Franco Locatelli, Giuseppe Gigli, Gabriele Maiorano, Ilaria Elena Palamà   +10 more
wiley   +1 more source

Deciphering the role of signal regulatory protein α in immunotherapy for solid tumors

Frontiers in Immunology
Therapies targeting immune checkpoints like programmed death receptor-1 and programmed death ligand-1 have demonstrated remarkable effectiveness in combating cancer.
Yulong Zhou, Xiyang Tang, Weiguang Du, Chen Shu, Chen Shu, Xiaolong Yan, Nan Ma, Jinbo Zhao   +7 more
doaj   +1 more source

An Engineered Biomimetic Nanoreactor With Cascade Functions for Targeted and Combinatorial Therapy of Ischemic Stroke

Advanced Healthcare Materials, Volume 15, Issue 38, 16 October 2026.
Preparation of RVG‐modified erythrocyte membrane‐coated HMPB nanocarriers loaded with L‐arginine and NBP (RM@HPAN) and its neuroprotective mechanism. After intravenous injection, RM@HPAN achieves prolonged circulation, RVG‐29‐mediated BBB penetration, and ischemic accumulation.
Shaofa Li, Ying Wu, Huimin Wei, Jinyong Teng, Zaizhi Yang, Jufang Chen, Bao Liao, Xiaoqin Huang, Lanqing Meng, Tong Li   +9 more
wiley   +1 more source

Current advances in 2025: A critical review of selected topics by the Association for the Advancement of Blood and Biotherapies (AABB) Clinical Transfusion Medicine Committee

Transfusion, EarlyView.
Nabiha H. Saifee, Jennifer Andrews, Mary Berg, Stella T. Chou, Mischa Covington, Elizabeth P. Crowe, Ruchika Goel, Juliana A. Guarente, Tina Ipe, Jeremy W. Jacobs, Jessica Jacobson, Cyril Jacquot, Jenna Khan, Thane A. Kubik, Theodros Mamo, Michael F. Murphy, Kerry O'Brien, Monica B. Pagano, Anil K. Panigrahi, Jacqueline N. Poston, Scott E. Potter, Simon J. Stanworth, Moritz Stolla, Alyssa Ziman, Ryan A. Metcalf   +24 more
wiley   +1 more source

Rewriting Tumor Immunity With Bacterial Membrane Vesicles: A Versatile and Potent Therapeutic Strategy

Advanced NanoBiomed Research, Volume 6, Issue 10, October 2026.
Bacterial membrane vesicles (BMVs) emerge as promising platforms for cancer immunotherapy owing to their intrinsic adjuvant properties and tunable cargo delivery capabilities. Their ability to modulate the tumor microenvironment, enhance antitumor immune responses, and support personalized therapeutic strategies highlights their growing potential as ...
Md Sifat Rahi, Md Mijanur Rahman, Asma Talukder, Urooj Yousaf Virk, Jennifer C. Wilson, Nigel McMillan, Ming Q. Wei   +6 more
wiley   +1 more source