Results 121 to 130 of about 35,822 (223)

Lithospermic Acid Improves Doxorubicin‐Induced Cardiomyopathy Through Sirtuin‐3‐Mediated Deacetylation of p53

Phytotherapy Research, Volume 40, Issue 3, Page 965-985, March 2026.
Lithospermic acid (LA) inactivates the p53 signaling pathway via directly targeting SIRT3, thereby alleviating oxidative stress and abnormal apoptosis in the progression of doxorubicin (Dox)‐induced cardiomyocytes. ABSTRACT Doxorubicin (Dox)‐induced cardiomyopathy (DIC) is characterized by significant myocardial damage that can progress to dilated ...
Yining Zhao, Tao Xu, Chao Ye, Ke Zhang, Xinyu Heng, Shaohong Huang, Yan Chen, Yitong Guo, Shengyi Shao, Zhi Wen, Chenwen Shao, Xiang Lu, Ning Sun, Hai Yang   +13 more
wiley   +1 more source

Comparing image quality of synchrotron and laboratory nano‐CT scans: a round robin study

Journal of Synchrotron Radiation, Volume 33, Issue 2, Page 489-507, March 2026.
A multi‐facility round‐robin comparison of synchrotron‐ and laboratory‐based nano‐computed tomography using a standardized 3D phantom reveals superior resolution and acquisition speed at synchrotrons, while advanced laboratory systems achieve competitive image quality with extended scan times; phase contrast modalities further enhance structural ...
Simon Wittl, Simon Zabler, Jonas Fell, Julie Villanova, Pierre Lhuissier, Stefanie Hildebrandt, Hans-Georg Herrmann   +6 more
wiley   +1 more source

Deep‐learning methods for contrast enhancement and artifact reduction in cryo‐electron tomography: a systematic analysis of the state of the art and proposed improvements

Acta Crystallographica Section D, Volume 82, Issue 3, Page 168-186, March 2026.
Cryo‐ET is a rapidly emerging technique that enables 3D visualization of complex biological structures, but present limits on signal‐to‐noise ratio and reconstruction quality pose challenges for downstream analysis. Here, we present a systematic analysis of state‐of‐the‐art deep‐learning methods for contrast enhancement and propose improvements in ...
Henry N. Jones, Aneesh Deshmukh, Kanupriya Pande   +2 more
wiley   +1 more source

First-line chemotherapy with selective internal radiation therapy for intrahepatic cholangiocarcinoma: The French ACABi GERCOR PRONOBIL cohort

JHEP Reports
Background & Aims: Selective internal radiation therapy (SIRT) is a promising option for liver-only unresectable intrahepatic cholangiocarcinoma (iCCA).
Nicolas Adamus, Julien Edeline, Julie Henriques, Nadim Fares, Thierry Lecomte, Anthony Turpin, Dewi Vernerey, Mathilde Vincens, Brice Chanez, David Tougeron, Christophe Tournigand, Eric Assenat, Matthieu Delaye, Sylvain Manfredi, Olivier Bouché, Nicolas Williet, Angelique Vienot, Lorraine Blaise, Léo Mas, Cindy Neuzillet, Alice Boilève, Gaël S. Roth   +21 more
doaj   +1 more source

Sirte

, 1988
Voce enciclopedica.
openaire   +2 more sources

Parameter Estimation in Comparative Judgment Under Random and Adaptive Scheduling Schemes

Journal of Educational Measurement, Volume 63, Issue 1, Spring 2026.
Abstract Comparative judgment is an assessment method where item ratings are estimated based on rankings of subsets of the items. These rankings are typically pairwise, with ratings taken to be the estimated parameters from fitting a Bradley‐Terry model. Likelihood penalization is often employed to ensure finiteness of estimates. Adaptive scheduling of
Ian Hamilton, Nick Tawn
wiley   +1 more source

Editorial: SIRT Family in Endocrinology [PDF]

Frontiers in Endocrinology, 2019
Tian Li, Tian Li, Fan Peng, Russel J. Reiter, Yang Yang   +4 more
openaire   +3 more sources

Reduced Versus Oxidized NAD+ Precursors Drive Distinct Transcriptomic, Proteomic, and Metabolic Profiles in Hepatocytes

The FASEB Journal, Volume 40, Issue 4, 28 February 2026.
Comparative transcriptomic, proteomic, and metabolomic analyses of reduced (NRH, NMNH) versus oxidized (NR, NMN) NAD+ precursors reveal that NRH and NMNH induce broader and more potent transcriptomic, proteomic, and metabolomic changes. Although all precursors increase NAD+ pathway metabolites, reduced precursors uniquely elicit a pseudo‐stress ...
Kasper T. Vinten, Bauke V. Schomakers, Simone Denis, Michel van Weeghel, Aldo Jongejan, Rob Ofman, Sander R. Piersma, Connie R. Jimenez, Georges E. Janssens, Rubén Zapata‐Pérez, Riekelt H. Houtkooper   +10 more
wiley   +1 more source

NAD+ Homeostasis Attenuates Japanese Encephalitis Virus Infection Progression

The FASEB Journal, Volume 40, Issue 4, 28 February 2026.
JEV infection in brain tissue triggers inflammation and stress in neuronal cells, leading to NAD+ depletion via the overactivation of PARPs and SIRTs. While compensatory biosynthetic pathways (de novo and salvage) were upregulated, the NAD+ level fell critically. In vitro NAMPT inhibition exacerbates this deficit and viral load.
Takele Adugna Kassegn, Zhancheng Tian, Junzheng Du, Qingli Niu, Jifei Yang, Zhang Hongge, Yuqing Song, Fengxue Chai, Zhonghui Zhang, Guiquan Guan, Hong Yin   +10 more
wiley   +1 more source

Predictive value of platelet-to-lymphocyte and neutrophil-to-lymphocyte ratio in HCC treated with sorafenib and radioembolization

JHEP Reports
Background & Aims: Herein we used data derived from the SORAMIC trial to explore the predictive value of systemic inflammatory markers (neutrophil-to-lymphocyte ratio [NLR] and platelet-to-lymphocyte ratio [PLR]) in patients with advanced ...
Osman Öcal, Melanie Alexandra Kimm, Thi Phuong Thao Hoang, Maciej Pech, Elif Öcal, Najib Ben Khaled, Bruno Sangro, Jens Ricke, Max Seidensticker, Moritz Wildgruber   +9 more
doaj   +1 more source