Results 141 to 150 of about 22,785 (248)
FPGA‐based scanner and SerialEM server for 4D‐STEM electron tomography
Acta Crystallographica Section D, Volume 82, Issue 10, Page 1203-1211, October 2026.Software for a multipurpose hardware board enables flexible scanning with a ready acquisition and processing pipeline to implement 4D‐STEM electron tomography.Four‐dimensional scanning transmission electron microscopy (4D‐STEM) enables the acquisition of diffraction patterns at every probe position in a dense array.
Shahar Seifer, Michael Elbaum
wiley +1 more source
The Role of EVs in the Aging Hematopoietic System
Aging Cell, Volume 25, Issue 10, October 2026.Extracellular vesicles from aged bone marrow carry pro‐inflammatory cargo that drives blood stem cell decline, while youthful vesicles restore or maintain stem cell function. Circulating vesicles therefore represent both a readout of hematopoietic aging and a potential therapeutic route.
Esra G. Kosebent +5 more
wiley +1 more source
Non-specific SIRT inhibition as a mechanism for the cytotoxicity of ginkgolic acids and urushiols
Ginkgolic acids and urushiols are natural alkylphenols known for their mutagenic, carcinogenic and genotoxic potential. However, the mechanism of toxicity of these compounds has not been thoroughly elucidated so far.
Sacconnay, Lionel +4 more
core +1 more source
Aging Cell, Volume 25, Issue 10, October 2026.Mitochondrial fission‐fusion imbalance contributes to age‐related cardio‐cerebral diseases like Alzheimer's disease, Parkinson's disease, Cerebral Infarction, Arteriosclerosis, Myocardial Infarction, Cardiac valve disease, Hypertension, and Cardiomyopathy. This review summarizes its regulatory mechanisms and interventions.
Yuyao Yin, Zijian Li
wiley +1 more source
MTR4: A Conserved Youth Factor for Vascular Endothelium
Aging Cell, Volume 25, Issue 10, October 2026.Senescence‐induced SYVN1 degrades MTR4 via K638 ubiquitination. MTR4 loss disrupts its binding to BUB3 and destabilizes BUB3, diminishing BUBR1 and driving endothelial senescence. MTR4 restoration reverses vascular aging in mice and extends C. elegans lifespan.
Zhenyuan Guo +7 more
wiley +1 more source
Ushbu maqolada molekulyar fizikaning muhim bo‘limlaridan biri bo‘lgan suyuqliklarning sirt qatlamidagi fizik jarayonlar va sirt taranglik hodisasi atroflicha yoritilgan.
Farg’ona viloyati, Farg’ona +1 more
core +1 more source
Acta Physiologica, Volume 242, Issue 10, October 2026.ABSTRACT Aim Repeated heat exposure may promote adaptive remodeling or cumulative tissue burden depending on thermal dose, but its graded molecular and functional consequences during recovery remain unclear. We examined whether repeated moderate (39°C) and severe (41°C) whole‐body hyperthermia produce distinct skeletal muscle trajectories involving ...
Cansu Yakin +4 more
wiley +1 more source
Experimental Physiology, Volume 111, Issue 10, Page 4646-4658, 1 October 2026.Abstract Metabolic syndrome (MetS) is a major contributor to cardiovascular disease and is characterized by impaired Ca2+ handling and mitochondrial dysfunction in cardiomyocytes. However, the upstream mechanisms linking metabolic stress to these alterations remain incompletely defined.
Firat Akat +3 more
wiley +1 more source
Background: This case report details the innovative use of selective internal radiation therapy (SIRT) with Yttrium-90 resin microspheres to treat a 73-year-old woman with a solitary fibrous tumor (SFT), a rare and challenging tumor type.
Omar Badran +4 more
core +1 more source
ChemMedChem, Volume 21, Issue 18, 28 September 2026.Pyrazolyl thioureas were designed and synthesized as sirtuin 1 (SIRT1) and sirtuin 2 (SIRT2) inhibitors. 6a (IC50 (SIRT1) = 5.3 µM; IC50 (SIRT2) = 2.2 µM) and 7f (IC50 (SIRT1) = 12.4 µM; IC50 (SIRT2) = 13.6 µM) showed micromolar inhibition on target enzymes and HepG2‐based assays confirmed a SIRT2‐mediated effect on tubulin acetylation. Docking studies
Matteo Lusardi +10 more
wiley +1 more source