Results 131 to 140 of about 22,785 (248)
, 2013 A: Mesenchymal stem cells either served as controls (not treated, without primary antibody, a–b; not treated, with primary antibody, c–d) or were transfected with sense (e–f) or antisense (g–h) with 1 µM in the presence of lipofectin for 24 h and ...
Parviz Shayan (325457) +6 more
core +1 more source
SGLT2i in heart failure: Cardiorenal mechanisms, clinical evidence and translational perspectives
Clinical and Translational Discovery, Volume 6, Issue 5, October 2026.SGLT2 inhibitors improve heart failure outcomes through integrated cardiorenal mechanisms. In the kidney, they reduce glucose and sodium reabsorption, promoting natriuresis, osmotic diuresis and renal protection. In the heart, they enhance myocardial energetics, reduce inflammation, oxidative stress, fibrosis and adverse remodelling, resulting in fewer
Jelica Grujic‐Milanovic +4 more
wiley +1 more source
Health Science Reports, Volume 9, Issue 10, October 2026.ABSTRACT Background Vitiligo is a chronic autoimmune disease characterized by the progressive destruction of melanocytes, resulting in depigmented skin macules. While traditionally viewed as a cutaneous disorder driven by a specific CD8+ T cell‐mediated interferon‐γ (IFN‐γ) signature, emerging research suggests that vitiligo may be a systemic condition
Federica Papaccio +2 more
wiley +1 more source
Bioactive sesquiterpenes from heartwood of Pterocarpus santalinus as potent SIRT-1 activators
Phytomedicine PlusBackground: The role of SIRT-1 in various physiological processes, such as ageing and metabolism, has garnered significant interest in scientific research.
Bashir Ahmad Lone +8 more
doaj +1 more source
SIRT3‐Dependent Actions of Berberine: From Molecular Therapies to Toxicity
Journal of Biochemical and Molecular Toxicology, Volume 40, Issue 10, October 2026.This study reveals that berberine's therapeutic versatility in metabolic, cardiovascular, and hepatic disorders stems from its modulation of the mitochondrial protein Sirt3. Understanding this mechanism explains both its broad efficacy and its organ‐specific toxicity, positioning berberine as a promising mitochondrial epigenetic modulator whose ...
Dareuosh Shackebaei +4 more
wiley +1 more source
SIRT-1 expression and activity in rat retinas.
, 2015 A) Expression of SIRT-1 at mRNA level was measured using qPCR in retinal extracts from control, diabetic, and aging rat retinas. MRNA levels were calculated as a ratio to β-actin expression and normalized to baseline controls.
Folami Lamoke (578654) +6 more
core +1 more source
Journal of Cachexia, Sarcopenia and Muscle, Volume 17, Issue 5, October 2026.ABSTRACT Chemotherapy commonly induces skeletal muscle dysfunction and cognitive impairment, complications that reduce treatment tolerance and quality of life. Skeletal muscle mass frequently declines during chemotherapy, with cohort studies reporting losses of 3%–10% across treatment courses, while chemotherapy‐induced cognitive impairment affects up ...
SoYoung Ahn +10 more
wiley +1 more source
Iron and Other Metal Ions in Human Health and Disease
MedComm, Volume 7, Issue 10, October 2026.Iron, copper, zinc, and calcium orchestrate cellular function through distinct yet cooperative mechanisms: redox‐active iron and copper cycle between oxidation states to act as Fenton catalysts and electron carriers in oxidative phosphorylation (OXPHOS); redox‐inert zinc serves as a structural component of zinc‐finger proteins and a catalytic cofactor ...
Xiaofeng Dai, Jitian Li
wiley +1 more source
Discover OncologyPrimary hepatocellular carcinoma (HCC) is a prevalent malignancy in China, often diagnosed at intermediate to advanced stages, limiting the feasibility of curative surgical resection. Yttrium-90 selective internal radiation therapy (90Y-SIRT) has emerged
Fang-Yuan Hu +5 more
doaj +1 more source