Results 151 to 160 of about 8,557 (169)

Synergistic inhibition of metastatic melanoma by carvacrol and chloroquine: an in vitro and in silico investigation of apoptosis and molecular targets. [PDF]

Med Oncol
Kłos P, Dabravolski S, Perużyńska M, Przekop A, Kostka P, Dziedziejko V, Droździk M, Chlubek D, Safranow K.   +8 more
europepmc   +1 more source

Machine learning-driven prediction of substrates for enzymes introducing or removing protein post-translational modifications. [PDF]

Commun Chem
Ridgeway NH, Chopra A, Lukinović V, Feldman M, Charih F, Levy D, Green JR, Biggar KK.   +7 more
europepmc   +1 more source

Explore sirtuin family: SIRT5 as a ticket for the entrance of the TBK1-RelA axis to skeletal muscle rejuvenation. [PDF]

Life Med
europepmc   +1 more source

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Linking SIRT2 to Parkinson’s Disease

ACS Chemical Biology, 2007
A recent study has identified selective inhibitors of the human silent information regulator 2 NAD (+)-dependent protein deacetylase, SIRT2, and has shown that these compounds protect against alpha-synuclein-mediated toxicity in cellular models of Parkinson's disease.
Adam L, Garske, Brian C, Smith, John M, Denu   +2 more
openaire   +2 more sources

ERK1/2 regulates SIRT2 deacetylase activity

Biochemical and Biophysical Research Communications, 2013
SIRT2 is a mammalian member of the Sirtuin family of NAD-dependent protein deacetylases. The function of SIRT2 can be modulated by post-translational modification. However, the precise molecular signaling mechanisms of SIRT2 and extracellular signal-regulated kinase (ERK)1/2 have not been correlated.
You Hee, Choi, Hangun, Kim, Sung Ho, Lee, Yun-Hye, Jin, Kwang Youl, Lee   +4 more
openaire   +2 more sources

Cbl regulates the activity of SIRT2

Biochemical and Biophysical Research Communications, 2014
SIRT2 is a member of the sirtuin family of NAD(+)-dependent protein deacetylases. It is involved in metabolic homeostasis and has been linked to the progression of age-related diseases. Casitas B-lineage lymphoma (Cbl) proteins regulate signal transduction through many pathways and, consequently, regulate cell function and development. Cbl proteins are
You Hee, Choi, Hangun, Kim, Younho, Han, Yun-Hye, Jin, Kwang Youl, Lee   +4 more
openaire   +2 more sources

Src regulates the activity of SIRT2

Biochemical and Biophysical Research Communications, 2014
SIRT2 is a mammalian member of the Sirtuin family of NAD(+)-dependent protein deacetylases. The tyrosine kinase Src is involved in a variety of cellular signaling pathways, leading to the induction of DNA synthesis, cell proliferation, and cytoskeletal reorganization.
You Hee Choi, Hangun Kim, Sung Ho Lee, Yun-Hye Jin, Kwang Youl Lee   +4 more
openaire   +2 more sources

SIRT2 ameliorates lipopolysaccharide-induced inflammation in macrophages

Biochemical and Biophysical Research Communications, 2014
SIRT2 is a NAD(+)-dependent deacetylases and associated with numerous processes such as infection, carcinogenesis, DNA damage and cell cycle regulation. However, the role of SIRT2 in inflammatory process in macrophage remains unclear.In the present study, we have evaluated the regulatory effects of SIRT2 in lipopolysaccharide (LPS)-stimulated ...
Ae Sin Lee, Yu Jin Jung, Dal Kim, Tung Nguyen-Thanh, Kyung Pyo Kang, Sik Lee, Sung Kwang Park, Won Kim   +7 more
openaire   +2 more sources