Results 211 to 220 of about 44,793 (241)
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SIRTUIN 1: Regulating the regulator
Biochemical and Biophysical Research Communications, 2008Earlier analyses on the sirtuin family of histone deacetylases and its well-known member SIRT1 had their primary focus mostly on the identification of cellular targets exploring molecular mechanisms and functional networks in the control of metabolic homeostasis, differentiation, apoptosis and cell survival.
Barbara, Zschoernig, Ulrich, Mahlknecht
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Sirtuin-1 and HIV-1: An Overview
Current Drug Targets, 2013Sirtuins are a family of NAD+-dependent protein deacetylases, which regulate cell survival and energy metabolism, inflammation and cancer. Recent studies have shown that sirtuin-1 (SIRT1) modulates Human Immunodeficiency Virus (HIV)-1 transcription. The HIV-1 Tat protein is a substrate for the deacetylase activity of SIRT1; SIRT1 recycles Tat to its ...
Pinzone MR +4 more
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Role of Sirtuin 1 in metabolic regulation
Drug Discovery Today, 2010Sirtuin proteins are an evolutionarily conserved family of NAD(+)-dependent protein deacetylases. Originally discovered in yeast as gene-silencing proteins, they subsequently emerged as key regulators of life span in yeast and other lower species.
Jose P, Silva, Claes, Wahlestedt
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A Dual Role for Sirtuin 1 in Tumorigenesis
Current Pharmaceutical Design, 2014Sirtuin 1 (SIRT1) is an NAD+-dependent histone deacetylase which regulates many normal physiological and pathological processes. In addition to its place in cellular energy metabolism, increasing evidence shows a role for SIRT1 in tumorigenesis, wherein it can function as either a tumor promoter or suppressor.
Yujiang, Fang, Michael B, Nicholl
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Nephroprotective action of sirtuin 1 (SIRT1)
Journal of Physiology and Biochemistry, 2013Sirtuins, silent information regulator 2 (Sir 2) proteins, belong to the family of NAD(+)-dependent enzymes with deacetylase or mono-ADP-ribosyltransferase activity. These enzymes are responsible for processes of DNA repair or recombination, chromosomal stability and gene transcription.
Dorota, Polak-Jonkisz +5 more
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Sirtuin 1 in immune regulation and autoimmunity
Immunology & Cell Biology, 2011The NAD‐dependent histone deacetylase sirtuin (Sirt)1 is implicated in a wide variety of physiological processes, ranging from tumorigenesis to mitochondrial biogenesis to neuronal development. Recent studies indicate that Sirt1 is a critical regulator of both the innate and adaptive immune response in mice and its altered functions are likely involved
Sinyi, Kong +2 more
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Complex roles of Sirtuin 1 in cancer and aging
Translational Research, 2011A ging is a process associated with structural and functional decline across diverse multiple organ systems, which leads to an increase in the risk of age-associated diseases and mortality rate over time. Aging is an increasing global issue because the world population is rapidly aging.
Zhiping, Liu, Liou Y, Sun
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Mitochondrial sirtuin 3 and various cell death modalities
Frontiers in Cell and Developmental Biology, 2022Boris Zhivotovsky +2 more
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Sirtuin 3 Alleviates Diabetic Cardiomyopathy by Regulating TIGAR and Cardiomyocyte Metabolism
Journal of the American Heart Association, 2021Lanfang Li +2 more
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