Results 221 to 230 of about 29,404,625 (274)

Taurine, Sirtuin-1 and TNF- α levels in different aged adults with periodontitis: a pilot study. [PDF]

BMC Oral Health
Sayedyousef H, Yilmaz O, Ozturk C, Demir B, Toygar HU, Balci N.   +5 more
europepmc   +1 more source

Histone H3K18 Lactylation Promotes the Malignant Progression of Wilms Tumor via a PSRC1/AKT/HIF‐1α Positive Feedback Loop

Advanced Science, Volume 13, Issue 56, 9 October 2026.
In nephroblastoma, aberrant glycolysis drives lactate accumulation, which elevates histone H3K18 lactylation via p300. Lactylation of the PSRC1 promoter activates its transcription. PSRC1 competitively binds AKT, relieving PTEN‐mediated inhibition and triggering AKT/mTOR/HIF‐1α signaling.
Yanping Wang, Hongjie Gao, Bifei Zhang, Xuetian Li, Ding Li, Aihua Cao, Fengyin Sun   +6 more
wiley   +1 more source

Nicotinamide Metabolism Constrains Memory CD8+ T Cell Formation Through a Putative HS1BP3‐SIRT1‐FOXO3‐BCL6 Axis

Advanced Science, Volume 13, Issue 57, 14 October 2026.
ABSTRACT Memory T cells exhibit long‐term persistence, a defining feature that underpins durable clinical responses to adoptive immunotherapies. The mechanisms that integrate metabolic cues with transcriptional control of memory fate remain undetermined. Here, we identify HS1‐binding protein 3 (HS1BP3) is preferentially expressed in memory CD8+ T cells.
Siyang Wang, Xiaoqian Fan, Yifan Huang, Chang Yao, Jixing Fan, Yu Ping, Xuan Zhao, Congcong Li, Chunyi Shen, Jiqi Shan, Jinyan Liu, Shengdian Wang, Zhen Zhang, Yi Zhang   +13 more
wiley   +1 more source

Overexpression of long noncoding RNA colorectal neoplasia differentially expressed protects spinal cords against ischemia by targeting microRNA-181a-5p/Sirtuin-1 axis. [PDF]

Front Neurol
Wang Z, Wang W, Tang R, Gao S, Zhu Y, Gu T, Jiang X, Shi E.   +7 more
europepmc   +1 more source

Mitochondria‐Targeted Nanotherapeutics: A Promising Strategy in Modulating Mitochondrial Function, Transfer, and Transplantation

Advanced Science, Volume 13, Issue 58, 19 October 2026.
This review summarizes the pathogenic role of mitochondria in diseases and highlights mitochondrial transfer and transplantation as emerging therapeutic strategies. It systematically discusses how nanomaterials are engineered to facilitate these processes, and critically examines the current challenges and future perspectives for their clinical ...
Yuanyuan Su, Zhiyan Gong, Jiao Mu, Lili Huang, Pengfei Yang, Chenli Zhang, Lingshan Zhao, Liling Yang, Jun Deng, Xiaohui Liao   +9 more
wiley   +1 more source

Correlation analysis of the expression levels of serum endothelial cell adhesion molecule-1 and sirtuin 1 protein in acute respiratory distress syndrome. [PDF]

J Med Biochem
Peng C, Sun Z, Liu Y, Liu Y, Zhao H.
europepmc   +1 more source

H3K9me3 inhibition reverses Alzheimer's progression by restoring synaptic and immune proteostasis across the brain–retina axis

Alzheimer's &Dementia, Volume 22, Issue 10, October 2026.
Abstract INTRODUCTION Epigenetic dysregulation is increasingly linked to aging and neurodegeneration, yet its contribution to retinal and brain pathology in Alzheimer's disease (AD) remains unclear. METHODS We quantified the repressive epigenetic mark histone H3 lysine 9 trimethylation (H3K9me3) in post mortem retinas and brains from donors spanning ...
Dieu‐Trang Fuchs, Jean‐Philippe Vit, Altan Rentsendorj, Yosef Koronyo, Julia Sheyn, Bhakta Prasad Gaire, Saba Shahin, Haoshen Shi, Oksana Chepurna, Miyah R. Davis, Jered W. Wilson, Stuart L. Graham, Vivek K. Gupta, Lon S. Schneider, Michael T. Kleinman, Tao Sun, Margaret Fahnestock, David A. Horne, Mehdi Mirzaei, Keith L. Black, Maya Koronyo‐Hamaoui   +20 more
wiley   +1 more source

Punicalagin Enhances Autophagy Through Sirtuin 1/FoxO3a Axis to Inhibit Intracellular Mycobacterium Abscessus Infection. [PDF]

Adv Sci (Weinh)
Bi K, Xu B, Cao D, Xu K, Zhang Y.
europepmc   +1 more source

Blood Flow Restriction Training in Stroke Rehabilitation: A Narrative Review of Current Evidence and Future Directions

Brain and Behavior, Volume 16, Issue 10, October 2026.
ABSTRACT Background Post‐stroke motor deficits cause disability, while paresis and comorbidities may limit high‐intensity training. Blood flow restriction training (BFRT) combines low‐intensity exercise with partial vascular occlusion and may promote neuromuscular adaptations at low loads.
Jiawei Tong, Lei Song, Juan Jin, Fangfang Li, Tao Huang, Hang Ying, Jiawei Zhu, Jue Wang, Jie Zhuang   +8 more
wiley   +1 more source

A Sirtuin-1-Targeted Gene-Activating Tetrahedral DNA Attenuates Bladder Fibrosis by Restoring Mitophagy in Fibroblasts via the SIRT1-FOXO3-BNIP3 Axis. [PDF]

Adv Sci (Weinh)
Wang W, Yan R, Lin L, Xiang L, Xia X, Peng L, Gao X, Chen J, Xiong Y, Zhou L, Lin Y.   +10 more
europepmc   +1 more source