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Targeting sirtuin 1/nuclear factor erythroid 2-related factor 2/tumor necrosis factor-α pathway to modulate hepatic ischemia reperfusion-induced injury. [PDF]

World J Hepatol
Kelleni MT, Abdelzaher WY, Adly M, Attya ME, Fawzy MA, Ibrahim MA.   +5 more
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SIRTUIN 1: Regulating the regulator

Biochemical and Biophysical Research Communications, 2008
Earlier analyses on the sirtuin family of histone deacetylases and its well-known member SIRT1 had their primary focus mostly on the identification of cellular targets exploring molecular mechanisms and functional networks in the control of metabolic homeostasis, differentiation, apoptosis and cell survival.
Barbara, Zschoernig, Ulrich, Mahlknecht
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Sirtuin-1 and HIV-1: An Overview

Current Drug Targets, 2013
Sirtuins are a family of NAD+-dependent protein deacetylases, which regulate cell survival and energy metabolism, inflammation and cancer. Recent studies have shown that sirtuin-1 (SIRT1) modulates Human Immunodeficiency Virus (HIV)-1 transcription. The HIV-1 Tat protein is a substrate for the deacetylase activity of SIRT1; SIRT1 recycles Tat to its ...
Pinzone MR, CACOPARDO, Bruno Santi, Condorelli F, DI ROSA, MICHELINO DANIELE ANTONIO, Nunnari G.   +4 more
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Role of sirtuin-1 in diabetic nephropathy [PDF]

Journal of Molecular Medicine, 2019
Diabetic nephropathy (DN) is a research priority for scientists around the world because of its high prevalence and poor prognosis. Although several mechanisms have been shown to be involved in its pathogenesis and many useful drugs have been developed, the management of DN remains challenging.
Weixia Sun, Lu Cai, Wanning Wang
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A Dual Role for Sirtuin 1 in Tumorigenesis

Current Pharmaceutical Design, 2014
Sirtuin 1 (SIRT1) is an NAD+-dependent histone deacetylase which regulates many normal physiological and pathological processes. In addition to its place in cellular energy metabolism, increasing evidence shows a role for SIRT1 in tumorigenesis, wherein it can function as either a tumor promoter or suppressor.
Yujiang, Fang, Michael B, Nicholl
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Targeting Sirtuin 1 signaling pathway by ginsenosides

Journal of Ethnopharmacology, 2021
Ginseng is a kind of traditional Chinese herbal medicine, known as "king of herbs" and widely used in China, South Korea, and other Asian countries. Ginsenosides are one of active components of Panax ginseng Meyer, which have many pharmacological effects, such as enhancing memory, improving immunity and cardiovascular system, delaying aging, and ...
Tingting Lou, Qingxia Huang, Hang Su, Daqing Zhao, Xiangyan Li   +4 more
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Nephroprotective action of sirtuin 1 (SIRT1)

Journal of Physiology and Biochemistry, 2013
Sirtuins, silent information regulator 2 (Sir 2) proteins, belong to the family of NAD(+)-dependent enzymes with deacetylase or mono-ADP-ribosyltransferase activity. These enzymes are responsible for processes of DNA repair or recombination, chromosomal stability and gene transcription.
Dorota, Polak-Jonkisz, Krystyna, Laszki-Szcząchor, Leopold, Rehan, Witold, Pilecki, Henryk, Filipowski, Małgorzata, Sobieszczańska   +5 more
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Sirtuin 1 in immune regulation and autoimmunity

Immunology & Cell Biology, 2011
The NAD‐dependent histone deacetylase sirtuin (Sirt)1 is implicated in a wide variety of physiological processes, ranging from tumorigenesis to mitochondrial biogenesis to neuronal development. Recent studies indicate that Sirt1 is a critical regulator of both the innate and adaptive immune response in mice and its altered functions are likely involved
Sinyi, Kong, Michael W, McBurney, Deyu, Fang   +2 more
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