Results 321 to 330 of about 74,229 (355)
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Plant Science, 2020
The sirtuin family of intracellular enzymes are able to catalyze a unique β-nicotinamide adenine dinucleotide (β-NAD+)-dependent Nε-acyl-lysine deacylation reaction on histone and non-histone protein substrates. Since 2000, the sirtuin family members have been identified in both prokaryotes and eukaryotes; tremendous accomplishments have also been ...
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The sirtuin family of intracellular enzymes are able to catalyze a unique β-nicotinamide adenine dinucleotide (β-NAD+)-dependent Nε-acyl-lysine deacylation reaction on histone and non-histone protein substrates. Since 2000, the sirtuin family members have been identified in both prokaryotes and eukaryotes; tremendous accomplishments have also been ...
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Sirtuins, epigenetics and longevity
Ageing Research Reviews, 2017Aging of organisms begins from a single cell at the molecular level. It includes changes related to telomere shortening, cell senescence and epigenetic modifications. These processes accumulate over the lifespan. Research studies show that epigenetic signaling contributes to human disease, tumorigenesis and aging.
Mateusz, Wątroba +5 more
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Slowing ageing by design: the rise of NAD+ and sirtuin-activating compounds
Nature Reviews Molecular Cell Biology, 2016Michael S Bonkowski, David A Sinclair
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Sirtuin activators mimic caloric restriction and delay ageing in metazoans
Nature, 2004Blanka Rogina +2 more
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Sirtuin 2 Inhibitors Rescue α-Synuclein-Mediated Toxicity in Models of Parkinson's Disease
Science, 2007Tiago Fleming Outeiro +2 more
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Regulation of Hypoxia-Inducible Factor 2α Signaling by the Stress-Responsive Deacetylase Sirtuin 1
Science, 2009Matthew S Alexander, Joseph A Garcia
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