Results 321 to 330 of about 87,529 (407)

Managing the negative regulation of Sirtuins in a murine model of premature ovarian failure: focusing on the key roles of antioxidants. [PDF]

J Ovarian Res
Nasab SE, Shahhoseini M, Tavana S.
europepmc   +1 more source

Sirtuins: The ‘magnificent seven’, function, metabolism and longevity

, 2007
Nassim Dali‐Youcef, Marie Lagouge, Sébastien Froelich, C. Koehl, Kristina Schoonjans, Johan Auwerx   +5 more
openalex   +2 more sources

USP28 Promotes Osimertinib Resistance in H1975 NSCLC Cells by Deubiquitinating and Stabilizing SIRT1

The Kaohsiung Journal of Medical Sciences, Volume 42, Issue 1, January 2026.
ABSTRACT Osimertinib (OSI) resistance in non‐small cell lung cancer (NSCLC) remains a significant challenge. This report explored the precise role of USP28 on OSI resistance in NSCLC and identified a functional downstream effector. OSI‐resistant H1975 cells (H1975/OSI) were established by long‐term OSI exposure.
Hu‐Sen Fan, Xiu‐Mei Li, Jia‐Qi Gu, Hai‐Feng Wang, Zhen‐Jiang Zhang   +4 more
wiley   +1 more source

Fermented Porcine Placenta and Its Dipeptides Modulate Cellular Senescence in Human Keratinocytes. [PDF]

Curr Issues Mol Biol
Choi YJ, Kang M, Jin MH, Kim J, Lee WK, Roh SS, Kang KS, Hwang GS, Park S, Lee S.   +9 more
europepmc   +1 more source

Synthesis and biological characterisation of sirtuin inhibitors based on the tenovins

, 2012
Anna R. McCarthy, Lisa Pirrie, Jonathan J. Hollick, Sébastien Ronseaux, Johanna Campbell, Maureen Higgins, Oliver Staples, Fanny Tran, Alexandra M. Z. Slawin, Sonia Laı́n, Nicholas J. Westwood   +10 more
openalex   +1 more source

Ramalin Ameliorates Alzheimer's Disease Pathology by Targeting BACE1, HDAC6, and MAPK Pathways

MedComm, Volume 7, Issue 1, January 2026.
Ramalin alleviates Alzheimer's disease pathology by selectively inhibiting HDAC6, reducing BACE1 levels, and suppressing neuroinflammation through downregulation of the NLRP3 inflammasome and iNOS. It restores synaptic function impaired by Aβ toxicity and improves cognitive performance in AD mouse models, APP/PS1 and 3xTg‐AD.
Yongeun Cho, Jeongmi Lee, Bo Youn Choi, Jin‐Ho Yun, Sukmin Han, Seung Hyun Baek, Jinsu Park, Yoonsuk Cho, Hark Kyun Kim, Eunae Kim, Leon F. Palomera, Jeein Lim, Yeji Jeon, Jeonghyeong Im, Ju‐Mi Hong, Tai Kyoung Kim, Sung Hyun Kim, Joung Han Yim, Dong‐Gyu Jo   +18 more
wiley   +1 more source

Melatonin attenuates atherosclerotic plaque vulnerability through SIRT6-dependent regulation of vascular smooth muscle cells senescence. [PDF]

Redox Biol
Wang Y, Zhao W, Zhang L, Guo P, Zou Y, Qin Z, Wang Y, Wu X.   +7 more
europepmc   +1 more source

Mastering Organoid Growth: A Complete Guide to Overcoming Methodological Challenges

MedComm, Volume 7, Issue 1, January 2026.
Organoids offer transformative 3D models that precisely mimic human organ architecture and function. This review details the latest methodology, emphasizing the cultivation of liver and other abdominal organoids. We analyze technological challenges (e.g., nutrient delivery, scalability, diversity) and provide practical insights for new researchers ...
Chunbao Jiao, Omer Faruk Karakaya, Neda Dadgar, Chase J. Wehrle, Zahra Massoud, Hanna Hong, Robert L. Fairchild, Nic Leipzig, Federico Aucejo, Wen Wee Ma, Jan Joseph Melenhorst, Sofia Ferreira Gonzales, Andrea Schlegel   +12 more
wiley   +1 more source

Targeting sirtuin 1/nuclear factor erythroid 2-related factor 2/tumor necrosis factor-α pathway to modulate hepatic ischemia reperfusion-induced injury. [PDF]

World J Hepatol
Kelleni MT, Abdelzaher WY, Adly M, Attya ME, Fawzy MA, Ibrahim MA.   +5 more
europepmc   +1 more source

Evaluation of sirtuin 1 as a predictor of cardiovascular outcomes in diabetic patients with limb-threatening ischemia [PDF]

Federico Biscetti, Maria Margherita Rando, Maria Anna Nicolazzi, Enrica Rossini, Michele Santoro, Flavia Angelini, Roberto Iezzi, Luis H. Eraso, Paul DiMuzio, Dario Pitocco, Massimo Massetti, Antonio Gasbarrini, Andrea Flex   +12 more
openalex   +1 more source