Results 331 to 340 of about 87,529 (407)

Regulation and Mechanism of Deleted in Breast Cancer‐1 on Dendritic Cell Function in Systemic Lupus Erythematosus

MedComm, Volume 7, Issue 1, January 2026.
LPS‐stimulated DC activation upregulated DBC1. DBC1‐deficient DC ameliorated murine SLE symptoms. DBC1 deficiency suppressed immune responses in DC. DBC1 deficiency lowered STAT5 expression and subsequent phosphorylation. STAT5 overexpression abolished murine SLE remission primed by DBC1 deficiency.
Ze Xiu Xiao, Rongzhen Liang, Yan Liu, Changyuan Huang, Qiannan Fang, Xiaojiang Hu, Julie Wang, Nancy Olsen, Dehua Wu, Song Guo Zheng   +9 more
wiley   +1 more source

Regulation of apoptosis, ferroptosis, and pyroptosis mediated by acetylation. [PDF]

Cell Death Discov
Lu W, Deng Y, Liu M, Hu Y, Yang K, Wang B, Li Y, Wang G, Ma L, Liu J, Xie Y, Li Q, Liu A, Zhang X, Xie P.   +14 more
europepmc   +1 more source

Lithocholic acid binds TULP3 to activate sirtuins and AMPK to slow down ageing

Qi Qu, Yan Chen, Yu Wang, Weiche Wang, Shating Long, Heng-Ye Yang, Jianfeng Wu, Mengqi Li, Xiao Tian, Xiaoyan Wei, Liu Yanhui, Shengrong Xu, Jinye Xiong, Chunyan Yang, Zhenhua Wu, Xi Huang, Changchuan Xie, Yaying Wu, Zheni Xu, Cixiong Zhang, Baoding Zhang, Jin-Wei Feng, Junjie Chen, Yuanji Feng, Huapan Fang, Liyun Lin, ZK Xie, Beibei Sun, Huayu Tian, Yong Yu, Hai‐long Piao, Xiao‐Song Xie, Xianming Deng, Chen‐Song Zhang, Sheng‐Cai Lin   +34 more
openalex   +1 more source

Conformational Analysis and NMR Data Assignment of Taraxerone Isolated From Cnidoscolus aconitifolius (Chaya)

Magnetic Resonance in Chemistry, Volume 64, Issue 1, Page 146-159, January 2026.
We report the first complete NMR assignment of taraxerone, a pentacyclic triterpenoid isolated from Cnidoscolus aconitifolius (chaya). Using 2D NMR, DFT, and NBO analysis, we resolved spectral ambiguities due to high‐order couplings and signal overlap. Two Ring A conformers were identified and characterized.
Mónica Díaz‐Fernández, Karla Cahun‐Uicab, Viviana Roche‐Llerena, Leonardo Hernández, Geonel Rodríguez‐Gattorno, Armando Ariza‐Castolo, María A. Fernández‐Herrera   +6 more
wiley   +1 more source

A SENP7-SIRT1-IL-10 Axis Driven by DeSUMOylation Promotes Breg Differentiation and Immune Evasion in Colorectal Cancer. [PDF]

Int J Biol Sci
Liao Y, Zhuo X, Huang Y, Xu H, Hao Z, Huang L, Zheng H, Zhou J.   +7 more
europepmc   +1 more source

Proteomic Biomarkers Are Linked to QTc Interval in Patients With Chronic Heart Failure

PROTEOMICS – Clinical Applications, Volume 20, Issue 1, January 2026.
ABSTRACT Objective This study investigates the link between circulating proteins and rate‐corrected QT (QTc) interval in patients with heart failure with reduced ejection fraction (HFrEF) and their association with cardiovascular outcomes. Methods and Results We analyzed 197 HFrEF patients from the prospective Serial Biomarker Measurements and New ...
Mylène Barry‐Loncq de Jong, Teun B. Petersen, Sabrina Abou Kamar, Navin Suthahar, Nick van Boven, K. Martijn Akkerhuis, Peter J. van der Spek, Peter D. Katsikis, Rudolf A. de Boer, Victor A. W. M. Umans, Eric Boersma, Folkert W. Asselbergs, Jasper J. Brugts, Sing‐Chien Yap, Isabella Kardys   +14 more
wiley   +1 more source

Structural basis of SIRT2 pre-catalysis NAD⁺ binding dynamics and mechanism. [PDF]

RSC Chem Biol
Zhang N, Pow KC, Chen L, Hao Q.
europepmc   +1 more source

Sirtuins in Women's Health. [PDF]

Pharmaceuticals (Basel)
Madhusudhana R, Hamza A, Boyle E, Pollock S, Cen Y.   +4 more
europepmc   +1 more source

Avenanthramide C From Oats Possibly Exerts Anti‐Inflammatory Effects in Human Umbilical Vein Endothelial Cells

Journal of Food Science, Volume 91, Issue 1, January 2026.
ABSTRACT Chronic kidney disease (CKD) is associated with inflammation and cardiovascular complications and is partly exacerbated by the uremic toxin indoxyl sulfate (IS). IS is known to activate the aryl hydrocarbon receptor (AhR) to promote vascular inflammation.
Hiroyuki Sasaki, Hirofumi Masutomi, Hajime Nagasawa, Yuma Matsumoto, Teruyuki Okuma, Tomoyuki Otsuka, Katsuyuki Ishihara, Yusuke Suzuki, Seiji Ueda   +8 more
wiley   +1 more source

A Double-Edged Role for SIRT7 in Cancer: Can Anti-Cancer Immunity Tip the Balance? [PDF]

Pharmaceuticals (Basel)
Tarighi S, Ning Z, Gámez-García A, Vaquero A, Braun T, Ianni A.   +5 more
europepmc   +1 more source