Results 341 to 350 of about 87,529 (407)

Epigenetic Age Prediction Using N6‐Methyladenine in the Buff‐Tailed Bumblebee (Bombus terrestris)

Aging Cell, Volume 25, Issue 1, January 2026.
In bumblebees, age‐related patterns of N6‐methyladenine can be used to build accurate epigenetic clocks that are responsive to lifespan‐extending interventions, providing the first proof of concept that this epigenetic mark can be used as a biomarker of aging.
Thibaut Renard, Morgane Boseret, Serge Aron   +2 more
wiley   +1 more source

Gene expression patterns of Sirtuin family members (SIRT1 TO SIRT7): Insights into pathogenesis and prognostic of Myelodysplastic neoplasm

João Vitor Caetano Goes, Mateus de Aguiar Viana, Letícia Rodrigues Sampaio, Clarissa Brenda Alves Cavalcante, Mayara Magna de Lima Melo, Roberta Taiane Germano de Oliveira, Daniela de Paula Borges, Paola Gyuliane Gonçalves, Ronald Feitosa Pinheiro, Howard Lopes Ribeiro   +9 more
openalex   +1 more source

Promising Results With NAD Supplementation in Rare Diseases With Premature Aging and DNA Damage

Aging Cell, Volume 25, Issue 1, January 2026.
Increased DNA damage leads to increased parylation, causing mitochondrial dysfunction. This happens when DNA repair is defective, for example in known diseases and DNA repair capacity varies between individuals, some being at higher risk for hyperparylation.
Vilhelm A. Bohr
wiley   +1 more source

Can Sirtuin 1 Serve as a Therapeutic Target in Pulmonary Arterial Hypertension? A Comprehensive Review. [PDF]

Molecules
Budziak S, Kloza M, Krzyżewska A, Baranowska-Kuczko M.   +3 more
europepmc   +1 more source

Genomic Perspective on Heterogeneity of Organs and Body Aging

Aging Cell, Volume 25, Issue 1, January 2026.
Organ‐specific and whole‐body intrinsic aging metrics reveal heterogeneous organ aging, which potentially can arise from the interplay between static germline variation, somatic mutations, epigenetic drift, transposable elements, and mitochondrial DNA changes, highlighting genomic pathways for precision, organ‐targeted aging interventions.
Shabnam Salimi, Daniel Raftery, Luigi Ferrucci   +2 more
wiley   +1 more source

Correction: Pezzotta et al. Low Nephron Number Induced by Maternal Protein Restriction Is Prevented by Nicotinamide Riboside Supplementation Depending on Sirtuin 3 Activation. <i>Cells</i> 2022, <i>11</i>, 3316. [PDF]

Cells
Pezzotta A, Perico L, Morigi M, Corna D, Locatelli M, Zoja C, Benigni A, Remuzzi G, Imberti B.   +8 more
europepmc   +1 more source

Markers in Infants of Mothers With Asthma and Associations With Respiratory Outcomes

Allergy, Volume 81, Issue 1, Page 145-156, January 2026.
In the BILD and BLT cohorts, we compared cord blood proteins in infants of mothers with and without asthma during pregnancy. Groups showed different protein levels. These markers were associated with postnatal lung function, bronchiolitis hospitalization, and asthma.
Carla Rebeca Da Silva Sena, Gabriela Martins Costa Gomes, Noëmi Künstle, Olga Gorlanova, Andrea Marten, Sven Schulzke, Florian Wyler, Vanessa E. Murphy, Paul D. Robinson, Peter D. Sly, Jakob Usemann, Benjamin Stoecklin, Ruth Steinberg, Sophie Yammine, Loretta Müller, Philipp Latzin, Pablo Sinues, Peter G. Gibson, Joerg Mattes, Adam Collison, Urs Frey, on behalf of the BILD and BLT Study Groups   +21 more
wiley   +1 more source

SIRT2 puts the brakes on human β cell proliferation: therapeutic opportunities and next challenges. [PDF]

J Clin Invest
Katz LS, Scott DK, Stewart AF.
europepmc   +1 more source

Propionibacterium acnes evades microbicidal phagocytosis by inhibiting the mitochondrial biogenesis of nucleus pulposus cells

The FEBS Journal, Volume 293, Issue 1, Page 295-317, January 2026.
P. acnes infection impairs the mitochondrial biogenesis of nucleus pulposus cells (NPCs) through the AMPK/SIRT‐1/PGC‐1α signaling pathway. This results in impaired mitochondria that are unable to generate sufficient ATP, and impaired delivery of mitochondrial reactive oxygen species to carry out the bactericidal process effectively.
Lemeng Ren, Changwei Li, Juntao Sun, Yuehuan Zheng, Yucheng Jiao, Jiancheng Zheng, Fangke Zhang, Yazhou Lin, Wenjian Wu, Peng Cao   +9 more
wiley   +1 more source

Liver molecular networks associated with drinking behavior in nonhuman primates. [PDF]

Alcohol Clin Exp Res (Hoboken)
Cox LA, Daunais JB, Howard TD, Li G, Puppala S, Chan J, Hamid Z, Gawrieh S, Lee SM, Ferguson B, Grant KA, Olivier M.   +11 more
europepmc   +1 more source