Results 151 to 160 of about 63,033 (309)

Association of Sirtuin 1 (SIRT1) Gene SNPs and Transcript Expression Levels With Severe Obesity

, 2011
Stephen J. Clark, Mario Falchi, Bob Olsson, Peter Jacobson, Stéphane Cauchi, Beverley Balkau, Michel Marre, Olivier Lantieri, Johanna C. Andersson‐Assarsson, Margareta Jernås, Timothy J. Aitman, Sylvia Richardson, Lars Sjöström, Hang Yee Wong, Lena Carlsson, Philippe Froguel, Andrew J. Walley   +16 more
openalex   +1 more source

Non‐Coding RNAs in Breast Cancer Radioresistance: Mechanisms, Functional Roles and Translational Potentials

Cell Proliferation, EarlyView.
Non‐coding RNAs (ncRNAs) regulate breast cancer radioresistance via cell cycle, DNA repair and tumour microenvironment pathways. Targeting ncRNAs (e.g., HOTAIR and miR‐155) with RNA‐based therapies (ASOs and CRISPR) shows promise but faces delivery challenges.
Xiaohui Zhao, Yuting Qiu, Jie Chen, Danni Wang, Zairui Wang, Shuang Ma, Yimin Liu, Guoying Liu, Zhuofei Bi   +8 more
wiley   +1 more source

Download the full PDF of Jefferson Surgical Solutions Spring 2009, Volume 4, Number 1. [PDF]

, 2009
Download the full PDF of Jefferson Surgical Solutions Spring 2009, Volume 4, Number ...

core   +1 more source

Sirtuin-1 Targeting Promotes Foxp3⁺ T-Regulatory Cell Function and Prolongs Allograft Survival

, 2011
Ulf H. Beier, Liqing Wang, Tricia Bhatti, Yujie Liu, Rongxiang Han, Guanghui Ge, Wayne W. Hancock   +6 more
openalex   +1 more source

A novel crosstalk between BRCA1 and sirtuin 1 in ovarian cancer [PDF]

, 2014
Da Li, Fangfang Bi, Nana Chen, Ji-Min Cao, Wuping Sun, Yiming Zhou, Chunyan Li, Qing Yang   +7 more
openalex   +1 more source

Combating muscle atrophy: emerging therapeutic targets that are fiber‐type‐specific

The FEBS Journal, EarlyView.
Inflammation, denervation or decreased insulin signaling activate proteolysis and cause muscle wasting. Pathological conditions like obesity and DMD can also exacerbate atrophy via PGD2–RhoA–ROCK2 signaling. In contrast, exercise, dietary interventions, and pharmacological agents can activate Ca2+/calcineurin–NFAT and AMPK–PGC‐1α–MEF pathways ...
Samrat Chakraborty, Raz Ben‐David, Shenhav Shemer   +2 more
wiley   +1 more source

The NAD World 2.0: the importance of the inter-tissue communication mediated by NAMPT/NAD+/SIRT1 in mammalian aging and longevity control [PDF]

, 2016
Imai, Shin-ichiro
core   +2 more sources

Sirtuin 1 activator SRT2104 protects Huntington's disease mice [PDF]

, 2014
Mali Jiang, Jennifer Zheng, Peng Qi, Zhipeng Hou, Jiangyang Zhang, Susumu Mori, James L. Ellis, George P. Vlasuk, Harvey E. Fries, Vipin Suri, Wenzhen Duan   +10 more
openalex   +1 more source

Propionibacterium acnes evades microbicidal phagocytosis by inhibiting the mitochondrial biogenesis of nucleus pulposus cells

The FEBS Journal, EarlyView.
P. acnes infection impairs the mitochondrial biogenesis of nucleus pulposus cells (NPCs) through the AMPK/SIRT‐1/PGC‐1α signaling pathway. This results in impaired mitochondria that are unable to generate sufficient ATP, and impaired delivery of mitochondrial reactive oxygen species to carry out the bactericidal process effectively.
Lemeng Ren, Changwei Li, Juntao Sun, Yuehuan Zheng, Yucheng Jiao, Jiancheng Zheng, Fangke Zhang, Yazhou Lin, Wenjian Wu, Peng Cao   +9 more
wiley   +1 more source

Mechanical stress-activated immune response genes via Sirtuin 1 expression in human periodontal ligament cells

, 2011
S-I Lee, K-H Park, S.-J. Kim, Yoon‐Goo Kang, Yeon-Jung Lee, E-C Kim   +5 more
openalex   +1 more source