Results 141 to 150 of about 29,404,575 (242)

Sirtuin 1 Activation Mitigates Murine Vasculitis Severity by Promoting Mitophagy. [PDF]

Circ Res
Atici AE, Jena PK, Carvalho TT, Ross BL, Aubuchon EA, Lane ME, Gomez AC, Lee Y, Fishbein MC, Azer J, Mesquita T, Chen S, Crother TR, Arditi M, Noval Rivas M.   +14 more
europepmc   +1 more source

Selective autophagy pathways in ageing and neurodegeneration: Emerging roles for mitophagy and nucleophagy

The FEBS Journal, EarlyView.
As we age, cells gradually accumulate damage, which can contribute to disease and neurodegeneration. This review explores how two cellular recycling processes, mitophagy and nucleophagy, remove damaged mitochondria and nuclear material, respectively, to maintain cell health and long‐term neuronal homeostasis.
Maria Markaki, Nektarios Tavernarakis
wiley   +1 more source

Sirtuin 1 deficiency mediates chronic kidney disease-induced inflammaging cardiovascular calcification. [PDF]

Mol Biomed
Xu L, Zheng Y, Liu M, Deng B, Qian X, Jiang C, Liu Y, Fan P, Rao Z, Chen M, Chen Z, Cai Z, Dong N, Zhu D, Li F.   +14 more
europepmc   +1 more source

M1 macrophage‐derived exosomes aggravate diabetic nephropathy by regulating the WTAP/S1PR2 axis

Journal of Diabetes Investigation, EarlyView.
ABSTRACT Background Diabetic nephropathy (DN) is a severe microvascular complication of diabetes mellitus. The specific role of M1 macrophage‐derived exosomes in DN progression remains largely unexplored. Methods THP‐1 monocytes were differentiated into M0 macrophages and polarized into M1 macrophages for exosome extraction.
Lei Li, Hongmei Liu, Yu Mao, Huanhuan Wang, Lige Song, Zhiqiang Kang   +5 more
wiley   +1 more source

Association Between Salivary Sirtuin-1 Levels and Periodontitis. [PDF]

J Clin Med
Lorente L, Hérnandez Marrero E, Abreu González P, Lorente Martín AD, Lorente Martín M, Marrero González MJ, Hernández Marrero C, Hernández Marrero O, Jiménez A, Hernández Padilla CM.   +9 more
europepmc   +1 more source

Innovations in Obesity Treatment: Beyond Adipose Tissue Dysfunction

Obesity Reviews, EarlyView.
Obesity drives chronic inflammation, insulin resistance, type 2 diabetes, and cancer development through adipocyte dysfunction. Addressing this multisystemic disorder requires integrated strategies beyond diet and exercise, such as thermogenesis activation via menthol or capsinoids and appetite control through GLP‐1/GIP agonists and neuromodulation to ...
Jesica Martínez‐Godfrey, Irene Pomares‐Bri, Paula de Juan‐Maciá, Mariló Olivares‐Vicente, Enrique Barrajón‐Catalán, Vicente Micol, Enrique Roche, María Herranz‐López   +7 more
wiley   +1 more source

BMI-Dependent Modulation of the Soluble RAGE-Sirtuin-1 Axis by Coffee Type in Coronary Artery Disease. [PDF]

Nutrients
Roggerio A, Strunz CMC, Polo GP, César LAM, Mansur AP.   +4 more
europepmc   +1 more source

Established and Emerging Biomarkers to Characterize Persons at Risk for Obesity—Paving the Way for Targeted Clinical Intervention Trials—A Comprehensive Position Paper

Obesity Reviews, EarlyView.
ABSTRACT Despite all efforts, obesity remains a major health concern worldwide, with continuously increasing rates, affecting approx. 14% of the total world population, being as high as 43% in some countries. As obesity is related to numerous comorbidities, including type 2 diabetes, cardiovascular diseases, and some types of cancer, the consequences ...
Farhad Vahid, Victoria Stopa, Laurent Malisoux, Yvan Devaux, Elsa Lamy, Fernando Capela e Silva, Sarah Forberger, Tiziana de Magistris, Antoni Sureda, Margalida Monserrat‐Mesquida, Maria Pérez‐Jiménez, Rajini Nagrani, Maria Giovanna Onorati, Michele Filippo Fontefrancesco, Jonathan Turner, Mahesh S. Desai, Josep Tur, Cristina Bouzas, Gino Gabriel Bonetti, Oliver Riedel, Gitte Ravn‐Haren, Rikke Andersen, Torsten Bohn   +22 more
wiley   +1 more source

Sirtuin 1 is a key molecular link between cellular senescence and heart failure. [PDF]

Front Mol Med
Krekora J, Drożdż J, Blasiak J.
europepmc   +1 more source

Epigenomic Cascades Across Organs in Metabolic Dysfunction–Associated Steatotic Liver Disease: New Therapeutic Horizons

Obesity Reviews, EarlyView.
ABSTRACT Metabolic dysfunction–associated steatotic liver disease (MASLD) is the most common chronic liver disorder worldwide, affecting approximately one‐third of the population and increasing the risk of severe hepatic and cardiovascular complications.
Shurui Yang, Zhongyu Huang, Sanchun Tan, Fengxia Liang, Li Chen   +4 more
wiley   +1 more source