Results 151 to 160 of about 27,568,409 (275)

Sirtuin 1 Activation Mitigates Murine Vasculitis Severity by Promoting Mitophagy. [PDF]

Circ Res
Atici AE, Jena PK, Carvalho TT, Ross BL, Aubuchon EA, Lane ME, Gomez AC, Lee Y, Fishbein MC, Azer J, Mesquita T, Chen S, Crother TR, Arditi M, Noval Rivas M.   +14 more
europepmc   +1 more source

Dietary interventions in acute kidney injury: From molecular mechanism to clinical trials

Experimental Physiology, EarlyView.
Abstract Ageing impairs renal resilience with an elevated risk of frequent and harmful acute kidney injury (AKI) that causes substantial morbidity and mortality among hospitalized patients. Since different damaging stimuli at the molecular, cellular and functional level contribute to this loss in kidney function, AKI's pathophysiology is heterogeneous ...
Felix C. Koehler, Pedro Rojas‐Morales, Roman‐Ulrich Müller   +2 more
wiley   +1 more source

Association Between Salivary Sirtuin-1 Levels and Periodontitis. [PDF]

J Clin Med
Lorente L, Hérnandez Marrero E, Abreu González P, Lorente Martín AD, Lorente Martín M, Marrero González MJ, Hernández Marrero C, Hernández Marrero O, Jiménez A, Hernández Padilla CM.   +9 more
europepmc   +1 more source

VEGF inhibitor‐induced vascular dysfunction involves redox‐sensitive PARP activation and SIRT1 disruption

Experimental Physiology, EarlyView.
Abstract Vascular endothelial growth factor receptor (VEGFR) inhibitors are effective antiangiogenic agents used in cancer therapy. However, they are associated with cardiovascular disease, including hypertension and vascular dysfunction. The molecular mechanisms underlying these cardiovascular toxicities are unclear, but oxidative stress might be ...
Karla B. Neves, Rheure Alves‐Lopes, Augusto C. Montezano, Rhian M. Touyz   +3 more
wiley   +1 more source

Sirtuin 1 is a key molecular link between cellular senescence and heart failure. [PDF]

Front Mol Med
Krekora J, Drożdż J, Blasiak J.
europepmc   +1 more source

Sirtuin 1

Nihon Shoni Arerugi Gakkaishi. The Japanese Journal of Pediatric Allergy and Clinical Immunology, 2018
openaire   +1 more source

FGF21/sirtuin 1 axis mediates the cardioprotective effects of high‐intensity interval training against doxorubicin‐induced cardiotoxicity by reducing inflammatory and oxidative stress

Experimental Physiology, EarlyView.
Abstract Doxorubicin (DOX) is a potent anthracycline chemotherapeutic agent, but its clinical use is limited by cumulative cardiotoxicity. Exercise, particularly high‐intensity interval training (HIIT), has emerged as an effective non‐pharmacological strategy to counteract chemotherapy‐induced cardiac injury.
Mahdiyeh Farahani, Abbas Ali Gaeini, Alireza Ghardashi Afousi, Mahboobeh Borjian Fard   +3 more
wiley   +1 more source

(Poly)phenols: Mechanisms of action and efficacy of contemporary supplements for exercise recovery and performance

Experimental Physiology, EarlyView.
Abstract (Poly)phenols are a diverse group of bioactive chemical compounds present in a wide range of plant‐ and animal‐based foods. Several thousands of (poly)phenols exist; many have potent biological effects, most notably antioxidant, anti‐inflammatory and vasodilatory.
Glyn Howatson, Tom Clifford
wiley   +1 more source

Sirtuin 1 as an emerging exerkine in the aging process: unveiling its multifaceted biological roles. [PDF]

Biogerontology
de Araújo Leite PL, Maciel LA, Patricio RCB, Pereira GLC, de Oliveira Lamounier AS, da Silva Aguiar S, Sousa CV, de Sousa Neto IV, Simões HG.   +8 more
europepmc   +1 more source

Sirtuin signalling governs calcium homeostasis and mitochondrial function in metabolic syndrome cardiomyocytes

Experimental Physiology, EarlyView.
Abstract Metabolic syndrome (MetS) is a major contributor to cardiovascular disease and is characterized by impaired Ca2+ handling and mitochondrial dysfunction in cardiomyocytes. However, the upstream mechanisms linking metabolic stress to these alterations remain incompletely defined.
Firat Akat, Leila Aryan, Suatnur Şık, Erkan Tuncay   +3 more
wiley   +1 more source