Results 191 to 200 of about 29,404,575 (242)

Regulatory role of sirtuin-1 by targeting MDM2 to mitochondria-associated membranes formation in the treatment of NAFLD. [PDF]

Cell Commun Signal
Zhang R, Zhang Q, Cui Z, Huang B, Li M, Ma H.   +5 more
europepmc   +1 more source

Hydroxamic Acids as HDAC Inhibitor Drug Leads for Malaria

Medicinal Research Reviews, Volume 46, Issue 6, Page 1477-1498, November 2026.
ABSTRACT Malaria is a global health threat, with an estimated 282 million cases and 610,000 malaria‐associated deaths reported in 2024. Most mortality is due to infection by Plasmodium falciparum parasites, with the highest burden occurring in Sub‐Saharan Africa.
Wisam A. Dawood, Jacinta R. Macdonald, Christian Anzenhofer, Tina S. Skinner‐Adams, Robert C. Reid, Thomas Kurz, David P. Fairlie, Katherine T. Andrews   +7 more
wiley   +1 more source

Trichosanthes kirilowii Maximowicz attenuates dexamethasone induced atrophy in C2C12 myotubes through a Sirtuin 1 associated mechanism. [PDF]

Sci Rep
Kim H, Hong JY, Yeo C, Jeon WJ, Kim H, Lee J, Lee YJ, Ha IH.   +7 more
europepmc   +1 more source

Novel Carbazole–Acylthiourea Derivatives: Synthesis, Antimicrobial, Antioxidant, Hemocompatibility, Cytotoxicity, and ADME‐Tox Profiling

ChemistryOpen, Volume 15, Issue 11, November 2026.
We synthesized four novel carprofen‐derived carbazole–acylthiourea propanamides with selective antimicrobial activity against Staphylococcus aureus, Enterococcus faecalis, and Candida albicans. Compound 1a provides combined antioxidant and antihemolytic protection.
Carmen Limban, Ioana Cristina Marinaş, Mariana Carmen Chifiriuc, Miron Teodor Căproiu, Florea Dumitraşcu, Erzsébet‐Eleonóra Kapronczai, Irina Zarafu, Diana Camelia Nuţă, Petre Ioniţă, Speranţa Avram, Cătălina Mareş, Andra Maria Păun, Bogdan Mihai Cristea, Carmellina Daniela Bădiceanu, Ilinca Margareta Vlad, Maria Coandă, Delia Laura Popescu, Coralia Bleotu   +17 more
wiley   +1 more source

A Cilia–Centered Nicotinamide Adenine Dinucleotide (NAD+) Signaling Network Regulates Hypothalamic Lysosomal Homeostasis and Metabolic Aging

Aging Cell, Volume 25, Issue 11, November 2026.
Aging‐associated NAD+ depletion in hypothalamic neurons shortens primary cilia and disrupts CHMP4B trafficking to lysosomes during lysosomal stress, leading to impaired TRPML1–mediated Ca2+ signaling and lysosomal stress responses. Calorie restriction restores hypothalamic NAD+ levels, ciliary structure, and lysosomal homeostasis, thereby improving ...
Se Eun Park, Eun Roh, Jae Woo Park, Seong Jun Kim, So Yeon Jeong, Chae Beom Park, Hyo Sun Lim, Ji Soo Kim, Mun Gyeom Kim, Myeong Ju Kim, Young In Cho, Wontae Jeong, Gil Myoung Kang, Sang‐Yeob Kim, Se Hee Min, Min‐Seon Kim   +15 more
wiley   +1 more source

Evaluation of Sirtuin 1 (SIRT1) and Sirtuin 3 (SIRT3) in serum and cerebrospinal fluid following fatal traumatic brain injury. [PDF]

Int J Legal Med
Poniatowski ŁA, Siwińska A, Kwiatkowska M, Olczak M.   +3 more
europepmc   +1 more source

Histone deacetylase inhibitors as venetoclax‐sensitising partners in acute myeloid leukaemia: Mechanisms, pharmacology and translational perspectives

British Journal of Pharmacology, Volume 183, Issue 21, Page 6261-6290, November 2026.
Abstract Venetoclax combined with hypomethylating agents has improved treatment for older or unfit patients with acute myeloid leukaemia (AML), but resistance and relapse remain common. This review analyses the rationale for combining venetoclax with inhibitors of histone deacetylase (HDAC).
Jaebok Lee, Marc Diederich
wiley   +1 more source

Phosphorylation‐Facilitated CKB Lactylation At K11 By GCN5 Enhances Creatine Kinase Activity and Mitigates Neuronal Damage After Cerebral Ischemia‐Reperfusion

Advanced Science, Volume 13, Issue 56, 9 October 2026.
This study uncovers hierarchical coordination between K11 lactylation and S199 phosphorylation of CKB in cerebral ischemia‐reperfusion injury. Such dual modifications potentiate CKB enzymatic function, remodel energy metabolism, alleviate oxidative stress and neuronal damage, and represent a viable therapeutic target for stroke treatment.
Chao Duan, Ruolin Zhang, Shihui Ding, Ying Feng, Tao Shen, Ziwei Wang, Wendai Bao, Ke Shui, Jun Qin, Jun Chen, Min Zhang, Zijing Ren, Dongmei Zhao, Xingrong Guo, Zhibing Ai, Xin Yang, Peiyang Zhou, Zhiqiang Dong   +17 more
wiley   +1 more source

Taurine, Sirtuin-1 and TNF- α levels in different aged adults with periodontitis: a pilot study. [PDF]

BMC Oral Health
Sayedyousef H, Yilmaz O, Ozturk C, Demir B, Toygar HU, Balci N.   +5 more
europepmc   +1 more source

Histone H3K18 Lactylation Promotes the Malignant Progression of Wilms Tumor via a PSRC1/AKT/HIF‐1α Positive Feedback Loop

Advanced Science, Volume 13, Issue 56, 9 October 2026.
In nephroblastoma, aberrant glycolysis drives lactate accumulation, which elevates histone H3K18 lactylation via p300. Lactylation of the PSRC1 promoter activates its transcription. PSRC1 competitively binds AKT, relieving PTEN‐mediated inhibition and triggering AKT/mTOR/HIF‐1α signaling.
Yanping Wang, Hongjie Gao, Bifei Zhang, Xuetian Li, Ding Li, Aihua Cao, Fengyin Sun   +6 more
wiley   +1 more source