Results 201 to 210 of about 63,033 (309)

Cardiomyocyte‐Specific Deletion of Sirtuin 5 Accelerates the Development of Heart Failure Upon Dysregulating Purine Metabolism

Acta Physiologica, Volume 241, Issue 11, November 2025.
ABSTRACT Aim Sirtuin 5 (SIRT5), a mitochondrial NAD+‐dependent deacylase, regulates fundamental cellular pathways, including energy substrate metabolism. The current study is designed to better elucidate the role of SIRT5 in the development of heart failure (HF). Methods Mice with cardiomyocyte‐specific deletion (cSirt5−/−) or overexpression (cSirt5‐Tg)
Nikole J. Byrne, Christoph Koentges, Katharina Pfeil, Julia C. Lueg, Sayan Bakshi, Aleksandre Tarkhnishvili, Ivan Vosko, Johannes Gollmer, Laura C. Birkle, Thomas Rathner, Stephan Birkle, Sibai Tang, Clara Rau, Michael M. Hoffmann, Katja E. Odening, Stephen Barnes, Landon Shay Wilson, Senka Ljubojevic‐Holzer, Markus Wallner, Dirk von Lewinski, Peter Rainer, Simon Sedej, Harald Sourij, Christoph Bode, Adam R. Wende, Andreas Zirlik, Heiko Bugger   +26 more
wiley   +1 more source

Sirtuin-1 (SIRT1) Is Required for Promoting Chondrogenic Differentiation of Mesenchymal Stem Cells

, 2014
Constanze Buhrmann, Franziska Busch, Parviz Shayan, Mehdi Shakibaei   +3 more
openalex   +1 more source

Effect of 1.2-epoxy-3[3-3[3.4-dimetoxyiphenil]-4h-1-benzopiran-4-on] Propane (epi) on Sirtuin-1 and Nuclear Factor-kB Expression of DMBA induced Mammary Tumors in sprague dawley rats [PDF]

, 2016
Ayyub Harly Nurung, Sri Herwiyanti, Dewi Kartikawati Paramita   +2 more
openalex   +1 more source

Blockade of cannabinoid CB1 receptors potentiates the anti‐fibrotic effects mediated by SGLT2 inhibition in a mouse model of diabetic nephropathy

British Journal of Pharmacology, Volume 182, Issue 21, Page 5355-5377, November 2025.
Background and purpose Diabetic nephropathy (DN) is a common complication of diabetes. Current treatments include renin‐angiotensin‐aldosterone system (RAAS) blockers and sodium‐glucose co‐transporter 2 (SGLT2) inhibitors. The cannabinoid CB1 receptor is a potential therapeutic target.
Océane Pointeau, Awa Isma Ba, Audrey Geissler, Romain Barbosa, Abhishek Basu, Arif Muhammad, Marina Nivot, Maéva Loriot, Julia Leemput, Patricia Passilly‐Degrace, Sébastien Causse, Laurent Demizieux, Hélène François, Bruno Vergès, Jianmin Duan, Geneviève Gaucher, Michael Harvey, Pascal Degrace, Glenn Crater, Resat Cinar, Tony Jourdan   +20 more
wiley   +1 more source

Suppression of Sirtuin-1 Increases IL-6 Expression by Activation of the Akt Pathway During Allergic Asthma [PDF]

, 2017
Lingling Tang, Qingge Chen, Ziyu Meng, Li Sun, Linyun Zhu, Jinjin Liu, Junsheng Hu, Zhenhua Ni, Xiongbiao Wang   +8 more
openalex   +1 more source

Mapping the transcriptional landscape of algal resistance to viral infection reveals a core expression program

New Phytologist, Volume 248, Issue 3, Page 1368-1384, November 2025.
Summary Algal blooms and their demise by viruses drive global‐scale ecological processes in the ocean. These blooms form the foundation of marine food webs, regulate microbial communities, and shape biogeochemical cycles. Although algal populations are constantly infected by viruses, resistant subpopulations frequently emerge after the infection.
Talia S. Shaler, Amir Fromm, Daniella Schatz, Shifra Ben‐Dor, Ester Feldmesser, Assaf Vardi   +5 more
wiley   +1 more source

Sirtuin 1 gene rs2273773 C>T single nucleotide polymorphism and protein oxidation markers in asthmatic patients

, 2015
Aida A. Mahmoud, Abdellah Hamed Khalil Ali, Essam Nour Eldin   +2 more
openalex   +1 more source

Epigallocatechin-3-Gallate from Green Tea Reduces Vascular Aging and Endothelial Cell Senescence by Modifying Autophagy and Ferroptosis through the Sirtuin 1 Signaling Pathway. [PDF]

ACS Omega
Zhang Y, Wang T, Wang L, Fang Z, Lu T, Chen S, Yan J, Qin C, Shen X, Kang N, Tian L, Cao F.   +11 more
europepmc   +1 more source

Fucoxanthin Abrogates Ionizing Radiation-Induced Inflammatory Responses by Modulating Sirtuin 1 in Macrophages. [PDF]

Mar Drugs, 2023
Kang H, Kim SC, Oh Y.
europepmc   +1 more source

Microbial Therapeutics in Cancer: Translating Probiotics, Prebiotics, Synbiotics, and Postbiotics From Mechanistic Insights to Clinical Applications: A Topical Review

The FASEB Journal, Volume 39, Issue 20, 31 October 2025.
This graphical abstract illustrates the multifaceted roles of probiotics, prebiotics, synbiotics, and postbiotics in cancer prevention and therapy. Key mechanisms include modulation of the gut microbiome, immune system regulation, enhancement of gut barrier function, and direct anti‐cancer activities like apoptosis induction and carcinogen inactivation.
Bantayehu Addis Tegegne, Desalegn Abebaw, Zigale Hibstu Teffera, Abebe Fenta, Habtamu Belew, Mekuriaw Belayneh, Mohammed Jemal, Mamaru Getinet, Temesgen Baylie, Fasil Bayafers Tamene, Wubetu Yihunie Belay, Samual Agegnew Wondim, Tirsit Ketsela Zeleke   +12 more
wiley   +1 more source