Results 241 to 250 of about 63,033 (309)

Evaluation of sirtuin 1 as a predictor of cardiovascular outcomes in diabetic patients with limb-threatening ischemia. [PDF]

Sci Rep
Biscetti F, Rando MM, Nicolazzi MA, Rossini E, Santoro M, Angelini F, Iezzi R, Eraso LH, Dimuzio PJ, Pitocco D, Massetti M, Gasbarrini A, Flex A.   +12 more
europepmc   +1 more source

Short‐chain acyl post‐translational modifications in cancers: Mechanisms, roles, and therapeutic implications

Cancer Communications, Volume 45, Issue 10, Page 1247-1284, October 2025.
Abstract Post‐translational modifications (PTMs) play a pivotal role in epigenetic regulation and are key pathways for modulating protein functionality. PTMs involve the covalent attachment of distinct chemical groups, such as succinyl, crotonyl, and lactyl, at specific protein sites, which alter protein structure, function, stability, and activity ...
Ting Wu, Yingqi Zhao, Xin Zhang, Yuanhe Wang, Qiuchen Chen, Mingrong Zhang, Huan Sheng, Yuying Zhang, Jinyu Guo, Jun Li, Yuxuan Fan, Ziqing Wang, Yalun Li, Haoran Wang, Minjie Wei, Xiaoyun Hu, Huizhe Wu   +16 more
wiley   +1 more source

Effects of Sirtuin 1 on the proliferation and osteoblastic differentiation of periodontal ligament stem cells and stem cells from apical papilla

, 2016
Qiongrong Zhang, Wei Cao, Yichen Liu, Shiman Cui, Yue Yan   +4 more
openalex   +1 more source

Effects of quercetin and derivatives on NAMPT/Sirtuin-1 metabolic pathway in neuronal cells: an approach to mitigate chemotherapy-induced cognitive impairment. [PDF]

Metab Brain Dis
John J, Das S, Kunnath A, Mudgal J, Nandakumar K.   +4 more
europepmc   +1 more source

Individual and Comorbid Influences of Chronic Stress and a Western Diet on Allostatic Loads and Cardiac Resilience, Adaptation and Proteome Profiles in Male Mice

Comprehensive Physiology, Volume 15, Issue 5, October 2025.
These findings support positive interactions between common risk factors in comorbid development of cardiovascular and affective disorders. Mitochondrial and innate defense paths may contribute to the influences of diet, stress, and preconditioning.
Makayla Nicholas, Tessa Helman, Brock Lyon, Saba Naghipour, Trissha Ybanez, Joshua T. Ingles, Chulkyu Kim, Nicolas J. C. Stapelberg, Jason N. Peart, John P. Headrick, Eugene F. du Toit   +10 more
wiley   +1 more source

Repetitive Compressive Loading Downregulates Mitochondria Function and Upregulates the Cartilage Matrix Degrading Enzyme MMP-13 Through the Coactivation of NAD-Dependent Sirtuin 1 and Runx2 in Osteoarthritic Chondrocytes. [PDF]

Int J Mol Sci
Takemoto M, Sugishita Y, Takahashi-Suzuki Y, Fujiya H, Niki H, Yudoh K.   +5 more
europepmc   +1 more source

Lactylation in cancer: Advances and opportunities for treatment resistance

Clinical and Translational Medicine, Volume 15, Issue 10, October 2025.
Aberrant lactylation plays a crucial role in the development of resistance to chemotherapy, immunotherapy, targeted therapy, and radiotherapy. Strategies to overcome this resistance include the inhibition of key glycolytic enzymes, targeting lactate transporters, synergistic therapeutic approaches, and the inhibition of specific site.
Keke Xu, Yiyi Shou, Ruiqi Liu, Hao Xiong, Xiaomeng Dai, Xuanwen Bao, Xiaoyan Chen, Luanluan Huang, Hailong Sheng, Haibo Zhang, Yanwei Lu   +10 more
wiley   +1 more source

Sirtuin 1 regulates the phenotype and functions of dendritic cells through Ido1 pathway in obesity. [PDF]

Cell Death Dis
de Lima J, Leite JA, Basso PJ, Ghirotto B, Martins da Silva E, Menezes-Silva L, Hiyane MI, Goes CP, Coutinho LL, de Andrade Oliveira V, Olsen Saraiva Câmara N.   +10 more
europepmc   +1 more source

Tubular Injury in Diabetic Kidney Disease: Early Diagnosis and Intervention Strategies

Diabetes/Metabolism Research and Reviews, Volume 41, Issue 7, October 2025.
ABSTRACT Diabetic kidney disease (DKD) is the most severe complication of diabetes mellitus and has poor prognosis, often progressing to end‐stage renal disease, causing substantial morbidity and mortality globally. While the pathogenesis of DKD has been extensively characterised, including glomerular hyperfiltration, podocyte injury, and ...
Yi Lv, Chen Ye, Zixi Li, Jiajia Ye, Huanhuan Cao, Chun Zhang, Huajun Jiang, Yumei Wang   +7 more
wiley   +1 more source

Impact of NAD-dependent deacetylase Sirtuin-1 in the osteophyte formation and the degradation of articular cartilage in osteoarthritis (OA)

, 2017
Kazuo Yudoh, K. Terauchi, Naoko Yui, Hajime Kobayashi, Hiroto Fujiya, Hisateru Niki, Haruki Musha   +6 more
openalex   +1 more source