Results 231 to 240 of about 27,568,409 (275)

Correlation between Sirtuin 1 downregulation and reduced vitamin D receptor expression in patients with diabetic neuropathy. [PDF]

Acta Diabetol
Latini A, De Benedittis G, Morgante C, Gasperini B, D'Ippolito I, Lauro D, Novelli G, Ciccacci C, Spallone V, Borgiani P.   +9 more
europepmc   +1 more source

Sirtuin-1 Regulates Mitochondrial Calcium Uptake Through Mitochondrial Calcium Uptake 1 (MICU1). [PDF]

Life (Basel)
Zhang X, Liu S, Su Y, Zhang L, Guo T, Wang X.   +5 more
europepmc   +1 more source

The clinical value of serum sirtuin-1 concentration in the diagnosis of metabolic dysfunction-associated steatotic liver disease. [PDF]

BMC Gastroenterol
Amirkhizi F, Taghizadeh M, Khalese-Ranjbar B, Hamedi-Shahraki S, Asghari S.   +4 more
europepmc   +1 more source

Inhibiting miR-200a-3p Increases Sirtuin 1 and Mitigates Kidney Injury in a Tubular Cell Model of Diabetes and Hypertension-Related Renal Damage. [PDF]

Biomolecules
Martinez-Arroyo O, Flores-Chova A, Mendez-Debaets M, Garcia-Ferran L, Escrivá L, Forner MJ, Redón J, Cortes R, Ortega A.   +8 more
europepmc   +1 more source

Evaluation of sirtuin 1 as a predictor of cardiovascular outcomes in diabetic patients with limb-threatening ischemia. [PDF]

Sci Rep
Biscetti F, Rando MM, Nicolazzi MA, Rossini E, Santoro M, Angelini F, Iezzi R, Eraso LH, Dimuzio PJ, Pitocco D, Massetti M, Gasbarrini A, Flex A.   +12 more
europepmc   +1 more source

Epigallocatechin-3-Gallate from Green Tea Reduces Vascular Aging and Endothelial Cell Senescence by Modifying Autophagy and Ferroptosis through the Sirtuin 1 Signaling Pathway. [PDF]

ACS Omega
Zhang Y, Wang T, Wang L, Fang Z, Lu T, Chen S, Yan J, Qin C, Shen X, Kang N, Tian L, Cao F.   +11 more
europepmc   +1 more source

MicroRNA-124a/Sirtuin 1 pathway inhibits autophagy to promote hepatocyte apoptosis in acute-on-chronic liver failure. [PDF]

Mol Biol Rep
Xu H, Wang X, Wang Y, Shen C, Ma L, Zhao C.   +5 more
europepmc   +1 more source

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AI-Powered Virtual Screening of Large Compound Libraries Leads to the Discovery of Novel Inhibitors of Sirtuin-1.

Journal of Medicinal Chemistry, 2023
The discovery of new scaffolds and chemotypes via high-throughput screening is tedious and resource intensive. Yet, there are millions of small molecules commercially available, rendering comprehensive in vitro tests intractable.
Anastasiia Gryniukova, Florian Kaiser, Iryna Myziuk, Diana O. Alieksieieva, Christoph Leberecht, P. Heym, Olga O. Tarkhanova, Yurii S. Moroz, Petro O. Borysko, V. Haupt   +9 more
semanticscholar   +1 more source

Dual control of mitochondrial biogenesis by sirtuin 1 and sirtuin 3

Mitochondrion, 2013
In this review, we discuss the dual control of mitochondrial biogenesis and energy metabolism by silent information regulator-1 and -3 (SIRT1 and SIRT3). SIRT1 activates the peroxisome proliferator activated receptor γ co-activator 1α (PGC-1α)-mediated transcription of nuclear and mitochondrial genes encoding for proteins promoting mitochondria ...
Julia Brenmoehl, Andreas Hoeflich
exaly   +3 more sources