Results 241 to 250 of about 27,568,409 (275)

Sirtuin-1 and HIV-1: An Overview

Current Drug Targets, 2013
Sirtuins are a family of NAD+-dependent protein deacetylases, which regulate cell survival and energy metabolism, inflammation and cancer. Recent studies have shown that sirtuin-1 (SIRT1) modulates Human Immunodeficiency Virus (HIV)-1 transcription. The HIV-1 Tat protein is a substrate for the deacetylase activity of SIRT1; SIRT1 recycles Tat to its ...
Pinzone MR, CACOPARDO, Bruno Santi, Condorelli F, DI ROSA, MICHELINO DANIELE ANTONIO, Nunnari G.   +4 more
openaire   +4 more sources

Increased levels of sirtuin‐1 in systemic lupus erythematosus

International Journal of Rheumatic Diseases, 2022
We investigated plasma sirtuin‐1 (SIRT1) levels in systemic lupus erythematosus (SLE) patients, and discussed potential of plasma SIRT1 as a biomarker for SLE.
Chan Yang, Rong Li, Wang-Dong Xu, A. Huang   +3 more
semanticscholar   +1 more source

Shear stress–induced cellular senescence blunts liver regeneration through Notch–sirtuin 1–P21/P16 axis

Hepatology, 2021
The mechanisms involved in liver regeneration after partial hepatectomy (pHx) are complicated. Cellular senescence, once linked to aging, plays a pivotal role in wound repair.
Juanli Duan, B. Ruan, P. Song, Zhiqiang Fang, Zhen Yue, Jingjing Liu, G. Dou, Hua Han, Lin Wang   +8 more
semanticscholar   +1 more source

SIRTUIN 1: Regulating the regulator

Biochemical and Biophysical Research Communications, 2008
Earlier analyses on the sirtuin family of histone deacetylases and its well-known member SIRT1 had their primary focus mostly on the identification of cellular targets exploring molecular mechanisms and functional networks in the control of metabolic homeostasis, differentiation, apoptosis and cell survival.
Barbara, Zschoernig, Ulrich, Mahlknecht
openaire   +2 more sources

The Role of Sirtuin 1 in Ageing and Neurodegenerative Disease: A Molecular Perspective.

Ageing Research Reviews
Sirtuin 1 (SIRT1), an NAD+-dependent deacetylase, has emerged as a key regulator of cellular processes linked to ageing and neurodegeneration. SIRT1 modulates various signalling pathways, including those involved in autophagy, oxidative stress, and ...
Riya Thapa, E. Moglad, Muhammad Afzal, G. Kumar, A. Bhat, Waleed Hassan Almalki, I. Kazmi, Sami I. Alzarea, Kumud Pant, Thakur Gurjeet Singh, S. Singh, Haider Ali   +11 more
semanticscholar   +1 more source

Impact of NF-κB Signaling and Sirtuin-1 Protein for Targeted Inflammatory Intervention.

Current Pharmaceutical Biotechnology
This detailed review disclosed the NF-κB pro-inflammatory gen's activity regulation and explored the therapeutic significance, activation, and inhibition. This study uncovers the structural intricacies of the NF-κB proteins and highlights the key role of
Sagar Das, Tuhin Mukherjee, Satyajit Mohanty, Nikita Nayak, Payel Mal, S. Ashique, Radheshyam Pal, Sourav Mohanto, Himanshu Sharma   +8 more
semanticscholar   +1 more source

The effects of curcumin supplementation on oxidative stress, Sirtuin-1 and peroxisome proliferator activated receptor γ coactivator 1α gene expression in polycystic ovarian syndrome (PCOS) patients: A randomized placebo-controlled clinical trial.

Diabetes & metabolic syndrome, 2020
BACKGROUND & AIMS Curcumin is a biologically active phytochemical ingredient found in turmeric and has antioxidant pharmacologic actions that may benefit patients with polycystic ovarian syndrome (PCOS). The aim in this trial was to evaluate the efficacy
Javad Heshmati, F. Golab, Mojgan Morvaridzadeh, E. Potter, M. Akbari-Fakhrabadi, F. Farsi, Sara Tanbakooei, F. Shidfar   +7 more
semanticscholar   +1 more source

Histone Deacetylase Sirtuin 1 Promotes Loss of Primary Cilia in Cholangiocarcinoma

Hepatology, 2021
Sirtuin 1 (SIRT1) is a complex NAD+‐dependent protein deacetylase known to act as a tumor promoter or suppressor in different cancers. Here, we describe a mechanism of SIRT1‐induced destabilization of primary cilia in cholangiocarcinoma (CCA).
Kishor Pant, E. Peixoto, Seth Richard, A. Biswas, M. G. O’Sullivan, N. Giama, Y. Ha, Jun Yin, P. Carotenuto, M. Salati, Yanan Ren, Rendong Yang, B. Franco, L. Roberts, S. Gradilone   +14 more
semanticscholar   +1 more source

Role of Sirtuin 1 in metabolic regulation

Drug Discovery Today, 2010
Sirtuin proteins are an evolutionarily conserved family of NAD(+)-dependent protein deacetylases. Originally discovered in yeast as gene-silencing proteins, they subsequently emerged as key regulators of life span in yeast and other lower species.
Jose P, Silva, Claes, Wahlestedt
openaire   +2 more sources

A Dual Role for Sirtuin 1 in Tumorigenesis

Current Pharmaceutical Design, 2014
Sirtuin 1 (SIRT1) is an NAD+-dependent histone deacetylase which regulates many normal physiological and pathological processes. In addition to its place in cellular energy metabolism, increasing evidence shows a role for SIRT1 in tumorigenesis, wherein it can function as either a tumor promoter or suppressor.
Yujiang, Fang, Michael B, Nicholl
openaire   +2 more sources