Results 111 to 120 of about 15,404 (212)

Asymmetric synthesis of (-)-(R)-sitagliptin

, 2012
The asymmetric synthesis of (-)-(R)-sitagliptin was achieved in seven steps from commercially available starting materials using the highly diastereoselective conjugate additions of either lithium (R)-N-benzyl-N- (α-methylbenzyl)amide or lithium (R)-N ...
Paul M. Roberts, Stephen G. Davies, Ai M. Fletcher, James E. Thomson, Roberts, PM, Thomson, JE, Lv, L, Davies, SG, Thomson, James, Linlu Lv, Davies, Stephen, Fletcher, AM, Roberts, Paul   +12 more
core   +1 more source

Sitagliptin induced acute severe nasopharyngitis

, 2017
Acute nasopharyngitis is one of the distressing adverse effects seen with the use of dipeptidyl peptidase-4 inhibitors like sitagliptin.
Krishnan, V., Rai, Shivali
core  

Comparative effectiveness of sitagliptin vs sulphonylureas in older people [PDF]

, 2019
BACKGROUND: two common anti-diabetic treatments used are sitagliptin and sulphonylureas however evidence examining their comparative effectiveness in older people is limited.
Sharma, M, Petersen, I, Nazareth, I
core  

Pharmacokinetic and pharmacodynamic evaluation of sitagliptin plus metformin.

, 2010
peer reviewedIMPORTANCE OF THE FIELD: Type 2 diabetes is an increasingly prevalent disease resulting from various complex combinations of defects in insulin secretion and insulin action.
Scheen, André, André J Scheen
core   +1 more source

Highly Efficient Asymmetric Synthesis of Sitagliptin

, 2016
A highly efficient synthesis of sitagliptin, a potent and selective DPP-4 inhibitor for the treatment of type 2 diabetes mellitus (T2DM), has been developed.
Yi Hsiao (771103), Michele Kubryk (1660960), Joseph D. Armstrong (2366482), Karl B. Hansen (1667377), Nelo Rivera (1601731), Jaume Balsells (1458115), Yongkui Sun (2265820), Christophe Malan (2366476), Nori Ikemoto (1843972), Edward J. J. Grabowski (2366479), Shane Krska (1814911), Feng Xu (89016), Bryon Simmons (2348086), Felix Spindler (1293300), Andrew Clausen (2253313), Thorsten Rosner (1504984)   +15 more
core   +1 more source

Electrochemical Synthesis of a Sitagliptin Precursor

A novel synthesis of sitagliptin based on a redox-active ester derived from the chiral pool is reported. The key step is an electrochemical nickel-catalyzed sp2-sp3 cross-coupling reaction using inexpensive nickel foam in an undivided cell.
Elisabeth K. Oehl (18435523), María Méndez (3685621), Siegfried R. Waldvogel (1434088), Sven Ruf (2030305), Paul T. Jirsch (18435526), Jasmin Hammes (16661576), Andreas Stenglein (4001738)   +6 more
core   +1 more source

Bioequivalence Study of a New Generic Fixed-Dose Combination of Sitagliptin (100 mg) and Glimepiride (2 mg) in Healthy Adult Volunteers under Fasting Condition

Chronicle of Diabetes Research and Practice
Introduction: The present study evaluated the bioequivalence of a fixed-dose combination (FDC) of sitagliptin and glimepiride with the originator reference product.
Prashant Kumthekar, Mihir Upadhyay, Koripalli S. Reddy, Sambasiva R. Puram, Basava S. Nallamekala   +4 more
doaj   +1 more source

(A) Confocal images represent insulin (red) immunostained pancreas sections from diabetic mice treated with vehicle, PSN632408, sitagliptin, or PSN632408 plus sitagliptin.

, 2013
(B) Quantification of β-cell mass in the pancreases of non-diabetic control mice and diabetic mice with restored normoglycemia after 7 weeks of treatment with PSN632408, sitagliptin, or PSN632408 and sitagliptin combination (3 to 4 mice per group).
Ansarullah (286218), Brittany DeRuyter (286222), Zhiguang Guo (286226), Alex Rabinovitch (286224), Martha Holstein (286220), Yan Lu (32611)   +5 more
core   +1 more source

Effects of sitagliptin and sitagliptin in combination with omega-3 on newly diagnosed type 2 diabetic Iraqi patients

, 2014
Type 2 diabetes is a complex disease that is typically diagnosed in midlife and is characterized by progressive defects in insulin secretion and action.
AL-Shukri, Deleen Abd-AL Wahab, AL-Abbassi, Mustafa Gazi   +1 more
core  

Noncardiac pulmonary edema induced by sitagliptin treatment

, 2014
A 74-year-old male patient with type 2 diabetes mellitus admitted to the emergency department with the complaints of progressive breathlessness, dry cough, and swollen lower extremities.
Suleyman Yuce, Tahir Belice, Aysel Kurt, Bayram Kizilkaya, Erkan Cure   +4 more
core   +1 more source