Results 91 to 100 of about 15,404 (212)

A review of sitagliptin with special emphasis on its use in moderate to severe renal impairment

, 2013
Vinay S Eligar,1 Stephen C Bain2 1University Hospital of Wales, Cardiff, UK; 2Singleton Hospital, Swansea University, Swansea, UK Abstract: Sitagliptin is the first dipeptidylpeptidase-4 inhibitor to be used in the management of type 2 diabetes.
Bain SC, Eligar VS
core  

Effect of sitagliptin on tissue characteristics of the carotid wall in patients with type 2 diabetes: a post hoc sub-analysis of the sitagliptin preventive study of intima-media thickness evaluation (SPIKE)

, 2018
Background Ultrasonic gray-scale median (GSM) of the carotid wall reflects its composition and low-GSM carotid plaque is considered to be vulnerable.
Mitsuyoshi Takahara, Naoto Katakami, Masahiko Gosho, on behalf of the Sitagliptin Preventive study of Intima-media thickness Evaluation (SPIKE) Collaborators, Hirotaka Watada, Tomoya Mita, Yoko Irie, Taka-aki Matsuoka, Iichiro Shimomura   +8 more
core   +1 more source

Sitagliptin: Is It Effective in Routine Clinical Practice? [PDF]

, 2015
Aim. The present study was conducted to determine the glycaemic effects of sitagliptin in type 2 diabetes patients. Methods. Data was collected from patient medical records of a major teaching hospital in Malaysia, from 2009 to 2012. Glycated hemoglobin
Rita Mohan Dallumal, Siew Siang Chua, Shireene Ratna Vethakkan, David Bin-Chia Wu   +3 more
core   +1 more source

Paroxysmal sympathetic hyperactivity secondary to hypoglycemic encephalopathy: A case report

Journal of Diabetes Investigation, Volume 17, Issue 7, Page 1231-1234, July 2026.
ABSTRACT A 48‐year‐old male was admitted to our hospital due to a hypoglycemic coma. Although his blood glucose level was increased after glucose administration, his impaired consciousness persisted. Magnetic resonance imaging indicated hypoglycemic encephalopathy.
Yushi Kohzuki, Junpei Yamamoto, Yuki Kaminaga, Yoko Kayaba, Hiroshi Onodera, Masahiro Usui   +5 more
wiley   +1 more source

Effect of sitagliptin on hepatic histological activity and fibrosis of nonalcoholic steatohepatitis patients: a 1-year randomized control trial

, 2018
Shahinul Alam,1 Jhumur Ghosh,1 Golam Mustafa,1 Mohammad Kamal,2 Nooruddin Ahmad1 1Department of Hepatology, 2Department of Pathology, Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh Background/purpose: Dipeptidyl peptidase 4 (DPP-4 ...
Alam S, Kamal M, Ghosh J, Ahmad N, Mustafa G   +4 more
core  

Effect of concomitant administration of L-glutamine and cycloart-23-ene-3β, 25-diol (B2) with sitagliptin in GLP-1 (7-36) amide secretion, biochemical and oxidative stress in streptozotocin - nicotinamide induced diabetic Sprague Dawley rats.

PLoS ONE, 2013
Previously we have reported that, cycloart-23-ene-3β, 25-diol (called as B2) and L-glutamine stimulated glucagon like peptide-1 (GLP-1) (7-36) amide secretion diabetic rats.
Sachin L Badole, Swapnil M Chaudhari, Pranita P Bagul, Sagar P Mahamuni, Rekha D Khose, Anuja C Joshi, Chandrashekhar G Raut, Anand A Zanwar   +7 more
doaj   +1 more source

Electromechanical modelling and simulation of human‐induced pluripotent stem cell‐derived cardiomyocytes predict drug‐induced contractility effects

The Journal of Physiology, Volume 604, Issue 13, Page 5629-5662, 1 July 2026.
Abstract figure legend A study described in this paper describes a new tool for hiPSC‐CM electromechanical behaviour simulations using mathematical modelling. The model enables in silico assays making drug testing quick, comprehensive and accurate. New hiPSC‐CM models can be used as a platform to integrate in vitro and in silico findings.
Milda Folkmanaite, Xin Zhou, Andreas Koschinski, Wan‐Hua Hong, Marilù Casini, Manuel Koch, Ursula Ravens, Remi Peyronnet, Manuela Zaccolo, Blanca Rodriguez   +9 more
wiley   +1 more source

The effect of sitagliptin on cardiovascular risk profile in Korean patients with type 2 diabetes mellitus: a retrospective cohort study

, 2016
Sooyoung Shin,1 Hyunah Kim2 1College of Pharmacy, Ajou University, Suwon, 2College of Pharmacy, Sookmyung Women’s University, Seoul, Republic of Korea Background: A 2013 postmarketing study suggested a possible link between saxagliptin use and ...
Shin S, Kim H
core  

Sitagliptin induced splenic infarcts

, 2018
  Sitagliptin belongs to the class of dipeptidyl pepti­dase-4 (DPP-4) inhibitors. DPP-4 inhibitors are remark­ably well tolerated oral antihyperglycemic drugs with an adverse effect profile similar to that of placebo.
Bashir, Mir Iftikhar; Department of Endocrinology, Sher-i-Kashmir Institute of Medical Scences, Srinagar, Kashmir, India, Misgar, Raiz Ahmad; Department of Endocrinology, Sher-i-Kashmir Institute of Medical Scences, Srinagar, Kashmir, India, Wani, Arshad Iqbal; Department of Endocrinology, Sher-i-Kashmir Institute of Medical Scences, Srinagar, Kashmir, India, Bhat, Javaid Ahmad; Department of Endocrinology, Sher-i-Kashmir Institute of Medical Sciences, Srinagar, Kashmir, 190011 Srinagr, India   +3 more
core   +1 more source

Sitagliptin eye drops prevent the impairment of retinal neurovascular unit in the new Trpv2 +/− rat model

Journal of Neuroinflammation
Impaired function of the retinal neurovascular unit (NVU) is an early event in diabetic retinopathy (DR). It has been previously shown that topical delivery of the dipeptidyl peptidase-4 (DPP-4) inhibitor sitagliptin can protect against diabetes-mediated
Hugo Ramos, Josy Augustine, Burak M. Karan, Cristina Hernández, Alan W. Stitt, Tim M. Curtis, Rafael Simó   +6 more
doaj   +1 more source