Results 71 to 80 of about 912 (125)

Rosuvastatin-Induced Rhabdomyolysis as a Result of Drug Interaction With Sitagliptin: A Case Report

Clinical Medicine Insights: Case Reports
Rhabdomyolysis was not reported in clinical trials with Sitagliptin alone. However, several reports in the literature on rhabdomyolysis resulted from the interaction between statins and Sitagliptin. In patients with type 2 diabetes and hyperlipidemia, it
Abdolamir Atapour, Mahnaz Momenzadeh, Mahsa Panahishokouh, Shirinsadat Badri   +3 more
doaj   +1 more source

Lactiplantibacillus plantarum AS21 Attenuates Sex‐Biased Glucose Intolerance in Aging Mice via Gut Mucosal Microbiota‐Derived Citrulline

Aging Cell, Volume 25, Issue 8, August 2026.
Aging induces sex‐differential glucose intolerance, with male‐specific citrulline depletion. Lactiplantibacillus plantarum AS21 elevates microbiota‐derived citrulline metabolism and enhances GLP‐1 secretion, improving glucose homeostasis. ABSTRACT Aging‐related metabolic decline, particularly impaired glucose tolerance, represents a growing challenge ...
Mengya Jia, Mengyan Chen, Hu Chen, Huiling Zhang, Ruixue Dou, Chaorui Wang, Muhammad Ishaq, Xiaoying Wei, Zitong Ding, Xusheng Guo   +9 more
wiley   +1 more source

MicroRNAs modulated by DPP-4 inhibitor and bedtime NPH insulin therapy in individuals with type 2 diabetes

Frontiers in Endocrinology
BackgroundMicroRNAs (miRNAs) and their target genes can elucidate mechanisms of drug action and serve as potential therapeutic biomarkers.MethodsTo evaluate the effects of bedtime NPH insulin and sitagliptin on serum miRNA expression in individuals with ...
Aritania Sousa Santos, Silvia Yumi Bando, Maria Lucia Cardillo Correa Giannella, Maria Elizabeth Rossi da Silva   +3 more
doaj   +1 more source

Effect of concomitant administration of L-glutamine and cycloart-23-ene-3β, 25-diol (B2) with sitagliptin in GLP-1 (7-36) amide secretion, biochemical and oxidative stress in streptozotocin - nicotinamide induced diabetic Sprague Dawley rats.

PLoS ONE, 2013
Previously we have reported that, cycloart-23-ene-3β, 25-diol (called as B2) and L-glutamine stimulated glucagon like peptide-1 (GLP-1) (7-36) amide secretion diabetic rats.
Sachin L Badole, Swapnil M Chaudhari, Pranita P Bagul, Sagar P Mahamuni, Rekha D Khose, Anuja C Joshi, Chandrashekhar G Raut, Anand A Zanwar   +7 more
doaj   +1 more source

Characterizing the SASP‐Dependent Paracrine Spreading of Senescence Between Human Brain Cell Types

Aging Cell, Volume 25, Issue 8, August 2026.
In this paper, we characterized the brain cell‐type‐specific SASP and defined the directionality of a paracrine spreading of senescence phenotypes. We unraveled ligand‐receptor pairs underlying this spreading and showed that inhibiting this interaction ameliorates senescence dissemination.
Taylor Russo, Markus Riessland
wiley   +1 more source

The Effects of Combined Antihypertensive and Antidiabetic Therapies on Cardiovascular Outcomes: A Systematic Review and Meta‐Analysis

Diabetes, Obesity and Metabolism, Volume 28, Issue 8, Page 6874-6887, August 2026.
ABSTRACT Aims Hypertension and diabetes frequently coexist, yet the net clinical impact of intentionally combining antihypertensive (AHTN) and antidiabetic (ADA) therapies on cardiovascular (CV) outcomes is uncertain. Here we quantified the effects of AHTN and ADA co‐therapy on CV and blood pressure (BP)/heart rate (HR) outcomes.
Wan Chin Hsieh, Brandon Michael Henry, István Édes   +2 more
wiley   +1 more source

Sitagliptin eye drops prevent the impairment of retinal neurovascular unit in the new Trpv2 +/− rat model

Journal of Neuroinflammation
Impaired function of the retinal neurovascular unit (NVU) is an early event in diabetic retinopathy (DR). It has been previously shown that topical delivery of the dipeptidyl peptidase-4 (DPP-4) inhibitor sitagliptin can protect against diabetes-mediated
Hugo Ramos, Josy Augustine, Burak M. Karan, Cristina Hernández, Alan W. Stitt, Tim M. Curtis, Rafael Simó   +6 more
doaj   +1 more source

Multi‐Parametric Magnetic Resonance Imaging to Assess Empagliflozin Effect on the Kidneys in People With Type 2 Diabetes Mellitus: A Pilot Clinical Trial

Diabetes, Obesity and Metabolism, Volume 28, Issue 8, Page 7416-7429, August 2026.
ABSTRACT Aims Empagliflozin is renoprotective in Type 2 diabetes mellitus (T2DM). Our primary aim was to assess empagliflozin's effect on glomerular filtration rate and renal vascular resistance using multiparametric MRI (MpMRI). Our secondary aim was to assess the impact of empagliflozin on additional MpMRI‐derived metrics including markers of tissue ...
Ruth P. Lim, Salma Qassin, Lucy McKenna, Emma Hornsey, Dominic Italiano, Leonid Churilov, Richard J. MacIsaac, Jas‐mine Seah, Elif I. Ekinci, The Austin EMPA‐MRI Study Group   +9 more
wiley   +1 more source

Sitagliptin Prevents Inflammation and Apoptotic Cell Death in the Kidney of Type 2 Diabetic Animals

Mediators of Inflammation, 2014
This study aimed to evaluate the efficacy of sitagliptin, a dipeptidyl peptidase IV (DPP-IV) inhibitor, in preventing the deleterious effects of diabetes on the kidney in an animal model of type 2 diabetes mellitus; the Zucker diabetic fatty (ZDF) rat ...
Catarina Marques, Cristina Mega, Andreia Gonçalves, Paulo Rodrigues-Santos, Edite Teixeira-Lemos, Frederico Teixeira, Carlos Fontes-Ribeiro, Flávio Reis, Rosa Fernandes   +8 more
doaj   +1 more source

A Systematic Review and Meta‐Analysis of Semaglutide Effects on Adipose Tissue and Emerging Effects on Brain and Cognition

Obesity Reviews, Volume 27, Issue 8, August 2026.
ABSTRACT Background In 2023 and 2024, research into semaglutide (SEMA), an antiobesity and antidiabetic medication, indicated potential benefits beyond its approved uses, particularly in preventing Alzheimer's disease (AD). This highlights the link between obesity and AD development.
Amene Saghazadeh, Mahsa Dolatshahi, Soheil Mohammadi, Sara Hosseinzadeh Kassani, Mahshid Naghashzadeh, Joseph E. Ippolito, Claude B. Sirlin, Bettina Mittendorfer, Matthew R. Brier, Suzanne E. Schindler, John C. Morris, Danny Mou, Hani Charles Soudah, Tammie L. S. Benzinger, Cyrus A. Raji   +14 more
wiley   +1 more source