Results 51 to 60 of about 23,280 (257)

Significance of Vascular Dipeptidyl Peptidase-4 Inhibition on Vascular Protection in Zucker Diabetic Fatty Rats

Journal of Pharmacological Sciences, 2014
.: To clarify the role of dipeptidyl peptidase-4 (DPP-4) inhibition in vascular tissues, we compared the effects of the poorly tissue-penetrative DPP-4 inhibitor sitagliptin to the highly tissue-penetrative DPP-4 inhibitor linagliptin in Zucker diabetic ...
Shinji Takai, Hiroshi Sakonjo, Denan Jin
doaj   +1 more source

A prospective randomized study comparing effects of empagliflozin to sitagliptin on cardiac fat accumulation, cardiac function, and cardiac metabolism in patients with early-stage type 2 diabetes: the ASSET study

Cardiovascular Diabetology, 2021
Background While the cardioprotective benefits of sodium-glucose cotransporter-2 (SGLT2) inhibitors have been established in patients with cardiovascular disease (CVD), their advantages over other anti-diabetic drugs at earlier stages remain unclear.
Shigenori Hiruma, Fumika Shigiyama, Shinji Hisatake, S. Mizumura, N. Shiraga, Masaaki Hori, T. Ikeda, T. Hirose, Naoki Kumashiro   +8 more
semanticscholar   +1 more source

Cardiovascular safety of sitagliptin in patients with type 2 diabetes mellitus: a pooled analysis

Cardiovascular Diabetology, 2013
Objective To compare the incidence of cardiovascular events and mortality in patients with type 2 diabetes mellitus treated with sitagliptin or non-sitagliptin comparators.
Engel Samuel S, Golm Gregory T, Shapiro Deborah, Davies Michael J, Kaufman Keith D, Goldstein Barry J   +5 more
doaj   +1 more source

Cardiovascular Outcomes of Sitagliptin in Type 2 Diabetic Patients with Acute Myocardial Infarction, a Population-Based Cohort Study in Taiwan. [PDF]

PLoS ONE, 2015
BACKGROUND:The cardiovascular safety and efficacy of sitagliptin, a dipeptidyl peptidase 4 (DPP-4) inhibitor, in type 2 diabetic patients after acute myocardial infarction (AMI) has so far remained uncertain.
Szu-Heng Wang, Dong-Yi Chen, Yu-Sheng Lin, Chun-Tai Mao, Ming-Lung Tsai, Ming-Jer Hsieh, Chung-Chuan Chou, Ming-Shien Wen, Chun-Chieh Wang, I-Chang Hsieh, Kuo-Chun Hung, Tien-Hsing Chen   +11 more
doaj   +1 more source

Efficacy and safety of once‐weekly semaglutide versus once‐daily sitagliptin as add‐on to metformin in patients with type 2 diabetes in SUSTAIN China: A 30‐week, double‐blind, phase 3a, randomized trial

Diabetes, obesity and metabolism, 2020
To evaluate the efficacy and safety of once‐weekly subcutaneous semaglutide, a glucagon‐like peptide‐1 (GLP‐1) analogue, versus once‐daily sitagliptin as add‐on to metformin in patients with type 2 diabetes (T2D) in a multiregional clinical trial.
L. Ji, Xiaolin Dong, Yi-Ming Li, Yu-Feng Li, Soo Lim, Ming Liu, Zu Ning, S. Rasmussen, T. Skjøth, Guo-Yue Yuan, F. Eliaschewitz   +10 more
semanticscholar   +1 more source

Simultaneous UV Spectrophotometric Method for Estimation of Sitagliptin Phosphate and Metformin Hydrochloride in Bulk and Tablet Dosage Form

International Journal For Multidisciplinary Research, 2022
Two simple, precise and economical UV methods have been developed for the simultaneous estimation of Sitagliptinphosphate and Metformin hydrochloride in bulk and pharmaceutical dosage form.
A. Loni, M. Ghante, S. Sawant
semanticscholar   +1 more source

Effect of a dipeptidyl peptidase-IV inhibitor, des-fluoro-sitagliptin, on neointimal formation after balloon injury in rats. [PDF]

PLoS ONE, 2012
BackgroundRecently, it has been suggested that enhancement of incretin effect improves cardiac function. We investigated the effect of a DPP-IV inhibitor, des-fluoro-sitagliptin, in reducing occurrence of restenosis in carotid artery in response to ...
Soo Lim, Sung Hee Choi, Hayley Shin, Bong Jun Cho, Ho Seon Park, Byung Yong Ahn, Seon Mee Kang, Ji Won Yoon, Hak Chul Jang, Young-Bum Kim, Kyong Soo Park   +10 more
doaj   +1 more source

Sitagliptin mitigates hypoxia/reoxygenation (H/R)-induced injury in cardiomyocytes by mediating sirtuin 3 (SIRT3) and autophagy

Bioengineered, 2022
Potential ischemia/reperfusion (I/R) injuries are commonly induced during treatment of cardiovascular diseases, such as acute myocardial infarction (AMI).
Mao Yang, Ning-Ning Xi, Meng Gao, Yan-Wei Yu   +3 more
semanticscholar   +1 more source

Pterostilbene vs sitagliptin

, 2023
Data share for the pterostilbene vs sitagliptin ...
Hayder Al-Aubaidy (14493926)
core   +2 more sources

Efficacy and Safety of Sitagliptin for the Treatment of New-Onset Diabetes after Renal Transplantation

International Journal of Endocrinology, 2014
New-onset diabetes after transplantation (NODAT) is a common comorbidity after renal transplantation. Though metformin is the first-line agent for the treatment of type 2 diabetes, in renal transplant recipients, metformin is frequently avoided due to ...
Brian P. Boerner, Clifford D. Miles, Vijay Shivaswamy   +2 more
doaj   +1 more source