Results 61 to 70 of about 758 (215)

Evolution‐guided yeast complementation reveals functional differences in human PSPH variants

FEBS Open Bio, EarlyView.
Ancient genomes can help guide which human genetic variants are tested experimentally. This study applies that idea to PSPH, a gene involved in serine biosynthesis, and uses high‐throughput yeast complementation to compare variant function. The findings reveal measurable differences among selected alleles and illustrate the value of evolution‐guided ...
Mauricio Campa‐Álvarez, Diana Ascencio, Miguel Vallebueno‐Estrada, Eduardo González‐Orozco, Christian Eduardo Martínez‐Guerrero, Rafael Montiel, Alexander DeLuna   +6 more
wiley   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

Structural snapshots of Xer recombination reveal activation by synaptic complex remodeling and DNA bending

eLife, 2016
Bacterial Xer site-specific recombinases play an essential genome maintenance role by unlinking chromosome multimers, but their mechanism of action has remained structurally uncharacterized. Here, we present two high-resolution structures of Helicobacter
Aleksandra Bebel, Ezgi Karaca, Banushree Kumar, W Marshall Stark, Orsolya Barabas   +4 more
doaj   +1 more source

Site-specific recombination caught in the act

Chemistry & Biology, 1997
AbstractThe recently determined crystal structure of Cre recombinase from bacteriophage P1, bound to its target DNA, sheds considerable light on the mechanism underlying a major type of site-specific DNA recombination, and shows how strand exchange can be achieved without reorganisation of the protein complex.
openaire   +2 more sources

Extremely Long Electron Lifetime in Spontaneously Passivated Polycrystalline Perovskite Layers via Illumination‐Assisted Trap Filling

Advanced Functional Materials, EarlyView.
ABSTRACT Perovskite solar cells (PSCs) are promising next‐generation photovoltaics. The high performance of PSCs is attributed to the long carrier lifetimes of perovskite photoabsorbers. However, the carrier lifetimes of polycrystalline perovskite layers, which serve as the photoabsorbers in practical PSCs, have remained limited to several tens of ...
Naoyuki Nishimura, Ryuzi Katoh, Takurou N. Murakami   +2 more
wiley   +1 more source

Engineering integrative vectors based on phage site-specific recombination mechanism for Lactococcus lactis

BMC Biotechnology, 2019
Background Site-specific integration system allows foreign DNA to be integrated into the specific site of the host genome, enabling stable expression of heterologous protein.
Innanurdiani Koko, Adelene Ai-Lian Song, Mas Jaffri Masarudin, Raha Abdul Rahim   +3 more
doaj   +1 more source

Mechanistic Control of C─H Bond Activation and C─C Coupling in Light‐Driven Methane Conversion to C2+ Products over Multifunctional Photocatalysts

Advanced Functional Materials, EarlyView.
Methane photocatalytic activation under mild conditions remains a formidable challenge in the synthesis of solar fuels. In this review, we emphasize the growing importance of multifunctional materials and hybrid systems within a unified mechanistic framework that integrates selective C─H bond activation, formation and control of intermediates, C─C ...
Di Hu, Yuheng Jiang, Vitaly V. Ordomsky, Bastian Mei, Zhiyong Tang, Andrei Y. Khodakov   +5 more
wiley   +1 more source

Functional Analysis of the Acinetobacter baumannii XerC and XerD Site-Specific Recombinases: Potential Role in Dissemination of Resistance Genes

Antibiotics, 2020
Modules composed of a resistance gene flanked by Xer site-specific recombination sites, the vast majority of which were found in Acinetobacter baumannii, are thought to behave as elements that facilitate horizontal dissemination. The A.
David L. Lin, German M. Traglia, Rachel Baker, David J. Sherratt, Maria Soledad Ramirez, Marcelo E. Tolmasky   +5 more
doaj   +1 more source

Bacteriophage lambda site‐specific recombination

Molecular Microbiology
AbstractThe site‐specific recombination pathway of bacteriophage λ encompasses isoenergetic but highly directional and tightly regulated integrative and excisive reactions that integrate and excise the vial chromosome into and out of the bacterial chromosome.
Gregory D. Van Duyne, Arthur Landy
openaire   +2 more sources

Interface‐Defect Synergy Engineering of Amorphous Ga2O3 for Voltage‐Tunable Dual‐Mode Optoelectronic Devices: Self‐Powered Imaging and Neuromorphic Vision

Advanced Functional Materials, EarlyView.
An interface‐defect co‐engineered strategy enables bias‐programmable integration of self‐powered photodetection and low‐power synaptic functionalities within a single‐material amorphous Ga2O3 device. This design achieves reversible switching via voltage modulation, supporting high‐contrast imaging and visual memory, and demonstrates a neuromorphic ...
Wanjun Li, Aijiang Yan, Lijuan Ye, Xuanyu Shan, Chunyan Liu, Hong Zhang, Shuren Zhou, Honglin Li, Di Pang, Yan Tang, Guoping Qin, Zhongqiang Wang, Peng Yu, Zhenxiang Cheng   +13 more
wiley   +1 more source