Results 111 to 120 of about 3,635,491 (290)
Molecular Oncology, EarlyView.This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi +6 more
wiley +1 more source
Molecular Oncology, EarlyView.We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee +3 more
wiley +1 more source
Molecular Oncology, EarlyView.Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou +4 more
wiley +1 more source
A study on sensitivity of seismic site amplification factors to site conditions for bridges
Bulletin of the New Zealand Society for Earthquake Engineering, 2018 Seismic site amplification factors and seismic design spectra for bridges are influenced by site conditions that include geotechnical properties of soil strata as well as the geological setting. All modern seismic design codes recognize this fact and assign design spectral shapes based on site conditions or specify a 2-parameter model with site ...
openaire +2 more sources
Molecular Oncology, EarlyView.In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico +5 more
wiley +1 more source
Molecular Oncology, EarlyView.This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault +12 more
wiley +1 more source
Effects on High Plasticity Clay Deposits On Site Ground Amplification [PDF]
, 1993 This paper reviews the effects of the Lorna Prieta earthquake on Treasure Island and discusses previous studies of site ground motion amplification. An independent study was performed in which it is shown that the site amplification is attributable to ...
Ferritto, John M.
core +1 more source
Earth, Planets and SpaceOne-dimensional site response analysis is widely used in seismic hazard assessment, but its explanatory capability is often considered to be limited when we have sites where existing velocity structures cannot reproduce the observed amplification ...
Ziqian Wang +4 more
doaj +1 more source
Molecular Oncology, EarlyView.We established the avian chorioallantoic membrane (CAM) assay as a scalable in vivo model for studying circulating tumor cells (CTCs). Human gastrointestinal tumors spontaneously released genetically validated CTCs that were detected across multiple platforms, demonstrating that the CAM model provides an accessible tool for investigating early cancer ...
Dennis Roth +17 more
wiley +1 more source
, 2003 This report documents the probability of liquefaction (POL) for the Pit Disassembly and Conversion Facility (PDCF). The procedure for analysis of a critical layer of interest requires the following basic steps: (1) establish the probability of occurrence
Lee, R.C.
core +1 more source