Results 111 to 120 of about 565,452 (295)
Study of Ground Vibration Site Effects on Substation in Inhomogeneous Strata
Shock and VibrationA large substation confronts the risk of frequent tectonic earthquakes with a relatively high magnitude, thus it is necessary to analyze the seismic response of the site.
Jingqiu Yang +4 more
doaj +1 more source
Molecular Oncology, EarlyView.EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain +10 more
wiley +1 more source
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
Molecular Oncology, EarlyView.CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak +10 more
wiley +1 more source
Nonlinear site amplification functions for Central and Eastern North America [PDF]
, 2017 Site amplification functions are used to modify ground motions from a reference bedrock condition to a surface condition based on the geologic features of the site of interest. Site amplification has been extensively studied and evaluated empirically for
Harmon, Joseph A.
core
Geosciences, 2018 This paper presents the general results in terms of maps, as well as geological and numerical models of a site effect study, that aimed at a better understanding of the ground motion amplification on the Gros-Morne hill, in the southeastern part of Port ...
Sophia Ulysse +3 more
doaj +1 more source
Molecular Oncology, EarlyView.Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen +14 more
wiley +1 more source
Molecular Oncology, EarlyView.A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel +12 more
wiley +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
A study on sensitivity of seismic site amplification factors to site conditions for bridges
Bulletin of the New Zealand Society for Earthquake Engineering, 2018 Seismic site amplification factors and seismic design spectra for bridges are influenced by site conditions that include geotechnical properties of soil strata as well as the geological setting. All modern seismic design codes recognize this fact and assign design spectral shapes based on site conditions or specify a 2-parameter model with site ...
openaire +2 more sources