Results 101 to 110 of about 565,452 (295)
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
Molecular Oncology, EarlyView.Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute +4 more
wiley +1 more source
Probabilistic Methodology for Developing Regional and Site-Class Dependent Seismic Site Amplification Factors [PDF]
, 2015 NEHRP guidelines for simplified seismic design provide site amplification factors as a function of the average shear wave velocity (Vs) of the top 30 m of a site, or Vs30.
Rodriguez-Marek, Adrian +5 more
core +1 more source
Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer
Molecular Oncology, EarlyView.Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni +11 more
wiley +1 more source
CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3
Molecular Oncology, EarlyView.PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh +12 more
wiley +1 more source
Molecular Oncology, EarlyView.Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau +8 more
wiley +1 more source
Uncertainty of site amplification derived from ground response analysis [PDF]
, 2023 Site-specific geotechnical ground response analyses (GRAs) are typically performed to evaluate stress and strain demands within soil profiles and/or to improve the estimation of site response relative to generic site terms from empirical prediction ...
Stewart, JP, Afshari, K
core
KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source
Effects on High Plasticity Clay Deposits On Site Ground Amplification [PDF]
, 1993 This paper reviews the effects of the Lorna Prieta earthquake on Treasure Island and discusses previous studies of site ground motion amplification. An independent study was performed in which it is shown that the site amplification is attributable to ...
Ferritto, John M.
core +1 more source
Variation of Earthquake Ground Motions with Focus on Site Amplification Factors: A Case Study [PDF]
, 2019 In this paper, an evaluation of the variation of earthquake ground motions with a focus on site amplification factors based on spectral analysis is presented. By using strong motion record obtained at six sites in Japan, probability distributions of site
Nagao, Takashi, Fukushima, Yasuhiro
core +1 more source