Results 91 to 100 of about 565,452 (295)
Vulnerability and Site Effects in Earthquake Disasters in Armenia (Colombia). I—Site Effects
Geosciences, 2018 The city of Armenia, Colombia has been repeatedly subjected to moderate magnitude earthquakes. Damage in that city for the 1999 (Mw6.2) event was disproportionate (maximum observed EMS-92 intensity of IX), even considering the small epicentral distance ...
Francisco J. Chávez-García +3 more
doaj +1 more source
Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers
Molecular Oncology, EarlyView.This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel +6 more
wiley +1 more source
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source
Topographic Effects on Peak Ground Acceleration: A Case Study for Baguio City
Applied SciencesBaguio City, a highly populated city in the mountainous portion of the Cordillera, is vulnerable to earthquake hazards due to its proximity to earthquake generators.
Rhommel N. Grutas +2 more
doaj +1 more source
COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells
Molecular Oncology, EarlyView.This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos +6 more
wiley +1 more source
Molecular Oncology, EarlyView.Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang +12 more
wiley +1 more source
Oligonucleotide primers used for drDDC amplification and site-directed mutagenesis. [PDF]
, 2013 Oligonucleotide primers used for drDDC amplification and site-directed mutagenesis.
Bruce M. Christensen (192340) +4 more
core +1 more source
Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer
Molecular Oncology, EarlyView.COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann +61 more
wiley +1 more source
Frontiers in Earth ScienceThe Ms 6.0 Changning Earthquake in 2019 caused severe damage to Gongquan Town, Sichuan. Our on-site investigation of seismic damage found that the three-dimensional topography and geological conditions of the town may have exacerbated the earthquake’s ...
Qiang Zhou +7 more
doaj +1 more source
Earth, Planets and Space, 2017 Most modern seismic codes account for site effects using an amplification factor (AF) that modifies the rock acceleration response spectra in relation to a “site condition proxy,” i.e., a parameter related to the velocity profile at the site under ...
Ahmed Boudghene Stambouli +3 more
doaj +1 more source