Results 71 to 80 of about 565,452 (295)

Polymerase-endonuclease amplification reaction for large-scale enzymatic production of antisense oligonucleotide [PDF]

, 2009
Synthetic oligonucleotides are contaminated with highly homologous failure sequences. Oligonucleotide synthesis is difficult to scale up because it requires expensive equipments, hazardous chemicals, and tedious purification process.
Deming Gou, Xiaolong Wang
core   +1 more source

Comparison between VS30 and other estimates of site amplification in Italy [PDF]

, 2006
During 5 microzonation projects in Italy, we had access to 46 estimates of Vs30 (30 obtained with down-hole or cross-hole measurements, plus 10 velocity profiles obtained with surface techniques, 6 sites were considered A without drilling, being rock ...
Gallipoli, M. R., Mucciarelli, M.
core   +2 more sources

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

Impacts of a Moderate-Sized Earthquake: The 2023 Magnitude (M_w) 4.7 Leyte, Leyte Earthquake, Philippines

Geosciences
On 15 January 2023, a shallow, moderate earthquake with a magnitude (Mw) of 4.7 and a depth of one kilometer struck the northern part of Leyte Island in the central Philippines. Originating along the northern Leyte segment of the Philippine Fault, a well-
Jeffrey S. Perez, Deo Carlo E. Llamas, Daniel Jose L. Buhay, Ryan Christian C. Constantino, Crystel Jade M. Legaspi, Kristine Dionne B. Lagunsad, Rhommel N. Grutas, Marc Marion Y. Quimson   +7 more
doaj   +1 more source

Rab14 regulates the transport of human papillomavirus to the trans‐Golgi network for infectious cell entry

FEBS Letters, EarlyView.
This study reveals that the small GTPase Rab14 is necessary for human papillomavirus (HPV) infection and plays an essential role in the transport of virions to the trans‐Golgi network (TGN). HPV in the early endosome (EE), which harbors GTP‐bound Rab14, is transported to the TGN through the switch of Rab14 from its GTP‐bound to GDP‐bound form.
Yoshiyuki Ishii, Iwao Kukimoto
wiley   +1 more source

Assessment dynamic ratio for traffic loading on highway bridges [PDF]

, 2011
The determination of characteristic bridge load effect is a complex problem. Usually, statistical extrapolation of simulated static load effects is used to derive a lifetime characteristic static load effect.
O\u27Brien, Eugene J., O'Brien, Eugene J., Rattigan, Paraic, González, Arturo, Caprani, Colin C.   +4 more
core   +1 more source

Re-thinking site amplification in regional seismic risk assessment [PDF]

, 2020
Probabilistic assessment of seismic hazard and risk over a geographical region presents the modeler with challenges in the characterization of the site amplification that are not present in site-specific assessment.
Kotha, Sreeram Reddy (Dr.), Cotton, Fabrice, Weatherill, Graeme (Dr.), Kotha, Sreeram Reddy, Cotton, Fabrice (Prof. Dr.), Weatherill, Graeme   +5 more
core   +1 more source

Impact of Ground Improvement on Soil Dynamic Properties and Design Spectrum

Buildings
Turkey is located on an active seismic belt, making the accurate determination of soil properties and earthquake effects essential for safe and reliable structural design.
Zeynep Kayışoğlu, Sami Oğuzhan Akbaş, İlker Kalkan   +2 more
doaj   +1 more source

Combining Earthquake Ground Motion and Ambient Vibration Recordings to Evaluate a Local High-Resolution Amplification Model—Insight From the Lucerne Area, Switzerland

Frontiers in Earth Science, 2022
Amplification factors are often estimated using empirical methods based on earthquake ground motion; however, especially in low-seismicity urban areas, recording a statistically representative number of high-quality signals may take years.
Paulina Janusz, Vincent Perron, Christoph Knellwolf, Donat Fäh   +3 more
doaj   +1 more source

An unexpected alternative viologen electron mediator site in tungsten‐containing formate dehydrogenase

FEBS Letters, EarlyView.
An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley   +1 more source