Results 81 to 90 of about 565,452 (295)
Amplification-Free Ratiometric Electrochemical Aptasensor for Point-of-Care Detection of Therapeutic Monoclonal Antibodies [PDF]
, 2023 The rapid quantification of therapeutic monoclonal antibodies (mAbs) is of great significance to their pharmacokinetics/pharmacodynamics (PK/PD) research and the personalized medication for disease treatment.
Jianwen Wan (12901530) +21 more
core +1 more source
GeosciencesWhile geodetic measurements have long been used to assess landslides, seismic methods are increasingly recognized as valuable tools for providing additional insights into subsurface structures and mechanisms. This work aims to characterize the subsurface
Franziska Glueer +6 more
doaj +1 more source
Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis
FEBS Letters, EarlyView.Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee +7 more
wiley +1 more source
, 2006 Site Amplification takes the role of site to the extreme by using design as a way to amplify the shifting conditions of a place. Such an approach aims to celebrate and harness these shifting intensities into a productive entanglement of site and design ...
Newell, Cathlyn L.
core
Probabilistic model for seismic effects on soft soil sites
Yantu gongcheng xuebao, 2023 The seismic response exhibits strong nonlinear amplification on soft soil sites. The common practice in different countries and regions for the seismic design codes is to provide a set of adjustment coefficients that are consistent with their respective ...
LI Ruishan 1, WU Jinhui 1, CHEN Longwei 1, YUAN Xiaoming 1, LI Mingrui 2
doaj +1 more source
FEBS Letters, EarlyView.Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley +1 more source
The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Primers used for gene amplification and site-directed mutagenesis. [PDF]
, 2016 Primers used for gene amplification and site-directed mutagenesis.
Caroline Wardrope (3350582) +5 more
core +1 more source
A Review of Parameters and Methods for Seismic Site Response
GeosciencesPrediction of the intensity of earthquake-induced motions at the ground surface attracts extensive attention from the geoscience community due to the significant threat it poses to humans and the built environment. Several factors are involved, including
A. S. M. Fahad Hossain +5 more
doaj +1 more source