Results 51 to 60 of about 5,149,605 (295)
Insights into PI3K/AKT signaling in B cell development and chronic lymphocytic leukemia
FEBS Letters, EarlyView.This Review explores how the phosphoinositide 3‐kinase and protein kinase B pathway shapes B cell development and drives chronic lymphocytic leukemia, a common blood cancer. It examines how signaling levels affect disease progression, addresses treatment challenges, and introduces novel experimental strategies to improve therapies and patient outcomes.
Maike Buchner
wiley +1 more source
Site‐directed alkylation and site‐site interactions in bovine seminal ribonuclease [PDF]
European Journal of Biochemistry, 1986 Active‐site histidine residues of bovine seminal RNase have been found to react with bromoacetic acid and with 2′(3′)‐O‐bromoacetyluridine (BrAcUrd) at a much faster rate than free histidine. The former reagent reacts preferentially at the pros‐N of His119 the latter is specific for the tele‐N of His12.
Donadio S. +4 more
openaire +4 more sources
Revista Brasileira de Obesidade, Nutrição e Emagrecimento, 2022 Introdução: Dentre os transtornos alimentares (TAs), têm a anorexia nervosa (AN) e a bulimia nervosa (BN), que através de blogs e sites Pró-Ana e Pró-Mia presentes nas redes sociais, estão sendo vistos como um estilo de vida.
Marília Somaggio Souza +1 more
doaj
Making tau amyloid models in vitro: a crucial and underestimated challenge
FEBS Letters, EarlyView.This review highlights the challenges of producing in vitro amyloid assemblies of the tau protein. We review how accurately the existing protocols mimic tau deposits found in the brain of patients affected with tauopathies. We discuss the important properties that should be considered when forming amyloids and the benchmarks that should be used to ...
Julien Broc, Clara Piersson, Yann Fichou
wiley +1 more source
Gases, 2023 Plant responses to air pollution have been extensively studied in urban environments. Nevertheless, detailed and holistic studies assessing their retaliation to air contaminants are still limited.
Harshita Singh +3 more
doaj +1 more source
FEBS Letters, EarlyView.Toll‐like receptors (TLRs) are important in the innate immune system. This study explores the zinc‐binding ability of the TLR2 TIR domain (TLR2TIR). We found that TLR2TIR binds zinc with nanomolar affinity through its cysteine residues. Two of them, C673 and C713, are vital for receptor activation, indicating that zinc may play a role in initiating ...
Vladislav A. Lushpa +8 more
wiley +1 more source
The power of microRNA regulation—insights into immunity and metabolism
FEBS Letters, EarlyView.MicroRNAs are emerging as crucial regulators at the intersection of metabolism and immunity. This review examines how miRNAs coordinate glucose and lipid metabolism while simultaneously modulating T‐cell development and immune responses. Moreover, it highlights how cutting‐edge artificial intelligence applications can identify miRNA biomarkers ...
Stefania Oliveto +2 more
wiley +1 more source
An efficient targeted nuclease strategy for high-resolution mapping of DNA binding sites
bioRxiv, 2016 We describe Cleavage Under Targets and Release Using Nuclease (CUT&RUN), a chromatin profiling strategy in which antibody-targeted controlled cleavage by micrococcal nuclease releases specific protein-DNA complexes into the supernatant for paired-end DNA
P. Skene, S. Henikoff
semanticscholar +1 more source
The tourist map, scientific tool that supports the exploration of protected areas, Bihor County, Romania [PDF]
GeoSport for Society, 2016 The study area is a Nature 2000 protected site from Bihor County, Romania. The present study aims at identifying the opportunities for the implementation of a bioeconomic exploitation system, by tourism development, according to its necessities for ...
Grigore Vasile HERMAN +6 more
doaj