Results 121 to 130 of about 407,599 (315)

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

[Photograph of a Baby Sitting Outside]

Negative of a baby sitting outside on a blanket.

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Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Cerebral hemodynamic response to upright position in acute ischemic stroke

Frontiers in Neurology
IntroductionConcerns exist that a potential mechanism for harm from upright activity (sitting, standing, and walking) early after an acute ischaemic stroke could be the reduction of cerebral perfusion during this critical phase.
Lilian B. Carvalho, Tina Kaffenberger, Brian Chambers, Karen Borschmann, Karen Borschmann, Christopher Levi, Leonid Churilov, Vincent Thijs, Vincent Thijs, Julie Bernhardt   +9 more
doaj   +1 more source

Measuring total and domain-specific sitting: A study of reliability and validity

, 2010
MARSHALL, A. L., Y. D. MILLER, N. W. BURTON, and W. J. BROWN. Measuring Total and Domain-Specific Sitting: A Study of Reliability and Validity. Med. Sci. Sports Exerc., Vol. 42, No. 6, pp. 1094-1102, 2010.
Marshall, Alison L., Burton, Nicola, Miller, Yvette D., Miller, Yvette, Brown, Wendy, Brown, W. J., Burton, N. W., Marshall, Alison   +7 more
core   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Sedentariness: A Need for a Definition

Frontiers in Public Health, 2018
Valentin Magnon, Frédéric Dutheil, Frédéric Dutheil, Catherine Auxiette   +3 more
doaj   +1 more source

Low back pain and sickness absence among sedentary workers: the influence of lumbar sagittal movement characteristics and psychosocial factors

Introduction: Low back pain remains a burden for society, since it can lead to sickness absence and work disability. Physical occupational risk factors can contribute to the development of back pain, yet little is known about any risks in sedentary ...
Bell, Jamie
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