Results 81 to 90 of about 146,886 (264)
FEBS Open Bio, EarlyView.The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer +7 more
wiley +1 more source
FEBS Open Bio, EarlyView.Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero +5 more
wiley +1 more source
FEBS Open Bio, EarlyView.Abruptly changing from aerobic to anaerobic conditions (sudden anaerobization) induced growth inhibition and a significant increase in intracellular labile ferrous iron in the aerotolerant anaerobe Amphibacillus xylanus. We found that free flavins mediate efficient electron transfer from NADH to ferric iron under anaerobic conditions, suggesting that ...
Shinya Kimata +13 more
wiley +1 more source
Guiding AlphaFold to predict how Munc13‐1 opens Syntaxin‐1
FEBS Open Bio, EarlyView.The syntaxin‐1 Habc‐domain (orange), linker (pink) and SNARE motif (yellow) form a closed conformation that binds to Munc18‐1 (violet) and is opened by the Munc13‐1 MUN domain (cyan) to form the SNARE complex that triggers neurotransmitter release.
Madhurima Chattopadhyay +2 more
wiley +1 more source
Evaluating the involvement of autolysosomes in the nuclear translocation of fluorescent proteins
FEBS Open Bio, EarlyView.Endogenously expressed fluorescent proteins can be degraded by autophagy and transported to cell nuclei via the nuclear pore complex. But in some cell lines, for example, HeLa cells which are positive for immunoreactivity of a receptor ligand, such as UCN I, in cell nuclei, fusion of autolysosome with the nuclear envelope is involved in the nuclear ...
Keiichi Ikeda
wiley +1 more source
The quest for systematization in educational psychology practice—the case of SDQ
Frontiers in PsychologyIntroductionThe field of Educational Psychology (EP) practice is currently shaped by debates on the balance between systematized and situated approaches.
Thomas Szulevicz, Jon Busck Arnfred
doaj +1 more source
How phagocytic cells kill bacteria: Lessons from a professional killer
FEBS Open Bio, EarlyView.How phagocytic cells ingest and kill bacteria has been studied for more than a century, but many questions remain unanswered. The study of the amoeba Dictyostelium discoideum brings new answers, and new questions. Professional phagocytic cells such as neutrophils and macrophages, as well as free‐living soil amoebae like Dictyostelium discoideum, employ
Otmane Lamrabet, Pierre Cosson
wiley +1 more source
Narrative Construction as a Psychosocial Research Method: Sharing Writing Practices
Forum: Qualitative Social Research, 2008 The discursive turn in the social sciences has opened the way for the appearance of new critical paradigms that have moved further away from the classic criterion of positivist validation.
Barbara Biglia, Jordi Bonet-Martí
doaj
Life-Writing in the works of Polish critics
AutobiografiaThis article explores the evolution of life-writing within Polish literary criticism, examining the shift from narcissistic tendencies in the 1990s to contemporary forms of exposing the reviewer’s ‘I.’ The author references the works of Karol Maliszewski,
Zuzanna Sala
doaj +1 more source
Experiments in Situated Knowledge [PDF]
, 2011 "We feel that even when all possible scientific questions have been answered, the problems of life remain completely untouched." -Ludwig Wittgenstein.\ud Part academic presentation, part performance, part discursive documentary, this presentation takes an alternative approach to the format of conference presentation in order to argue, by constructive ...
Punton, Lesley, Hamlyn, Jim
openaire