Results 71 to 80 of about 146,886 (264)
Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis
FEBS Letters, EarlyView.Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee +7 more
wiley +1 more source
(Dis/Re)Articulate Contexts Identities:
DIIDThe article reflects on the cultural, social, and political role of the ‘place’ construct for a meaningful social regeneration of communities within the dynamics of culture, power, and economy. We focus on the role of public spaces in the framework of an
Annalinda De Rosa, Davide Fassi
doaj +1 more source
Modelling stem cell differentiation related processes—A practical overview for biologists
FEBS Letters, EarlyView.Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source
Riereta.net: Epistemic and Political Notes From a Techno-Activist Ethnography
Forum: Qualitative Social Research, 2007 In this article we report on an ethnographic research experience on Riereta, a techno-activist workshop located in Barcelona, where free software and other technologies are developed and put at the disposal of other political projects and activist ...
Blanca Callén +7 more
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Teacher’s Situated Knowledge Through Metaphor Construction and Its Story- Licensing
Lenguaje, 2018 This theoretical article argues for metaphor construction and development to explain how teachers situate their knowledge and make sense of their teaching lives and practices.
Héctor Manuel Serna Dimas
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Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Molecular Oncology, EarlyView.BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi +11 more
wiley +1 more source
Translating whole‐genome doubling into precision medicine in cancer
Molecular Oncology, EarlyView.Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley +1 more source
Molecular Oncology, EarlyView.Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche +10 more
wiley +1 more source
Praktyki kontrfaktualne w narracjach naukowych i fikcjonalnych
Teksty Drugie, 2017 This article deals with counterfactual practices in history and the historical novel (whose production has increased in the last few years, and which presents alternative versions of the past), as well as in areas where the humanities and the natural or
Małgorzata Sugiera
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