Results 51 to 60 of about 146,579 (266)

ESR1 methylation and ESR1 mutations in circulating tumor cells (CTCs) and paired plasma‐cfDNA of advanced breast cancer patients: A feasibility proof‐of‐concept study

open access: yesMolecular Oncology, EarlyView.
Circulating tumor cells (CTCs) and plasma cell‐free DNA (cfDNA) were analyzed to detect ESR1 mutations and methylation in patients with advanced breast cancer. CTC‐derived DNA showed higher sensitivity for mutation detection and revealed complementary genetic and epigenetic alterations, highlighting the added value of CTC analysis for understanding ...
Dimitra Stergiopoulou   +12 more
wiley   +1 more source

Circulation et production des savoirs.

open access: yesTerrains/Théories, 2020
This article explores the issue of knowledge and epistemology. By exchanging on their respective disciplinary perspectives, methods and approaches, the authors question the production and circulation of knowledge.
Mona Gérardin-Laverge   +1 more
doaj   +1 more source

DNA methylation and expression of MAPRE3 affect overall survival of early‐stage non‐small cell lung cancer patients

open access: yesMolecular Oncology, EarlyView.
Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen   +14 more
wiley   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

open access: yesMolecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi   +11 more
wiley   +1 more source

Riereta.net: Epistemic and Political Notes From a Techno-Activist Ethnography

open access: yesForum: Qualitative Social Research, 2007
In this article we report on an ethnographic research experience on Riereta, a techno-activist workshop located in Barcelona, where free software and other technologies are developed and put at the disposal of other political projects and activist ...
Blanca Callén   +7 more
doaj  

Community Practice and Critical Community Research: Perspectives from Conviviality and the CABLE Approach

open access: yesDiaconia, 2019
This article discusses issues related to the development of critical community research. It addresses the need for a critical and engaged approach related to the present societal context of growing diversity and complexity as ...
Tony Addy
doaj   +1 more source

From tumor‐centric to ecosystem‐based hypotheses in brain tumor research and care

open access: yesMolecular Oncology, EarlyView.
Primary brain tumors, whether in adults or children, present a major challenge because of their dramatic prognosis and the ongoing lack of efficient therapeutic approaches. In recent years, a shift has occurred from tumor‐centric concepts to a more holistic view of these tumors as dynamic ecosystems.
Julie Gavard   +8 more
wiley   +1 more source

A Text of Texts…almost a Texture

open access: yesTecnoscienza, 2011
This lecture intends to be a journey through ongoing conversations that over time gave a situated meaning to the black box of STS. It tells the story (or rather stories) of how these perspectives have influenced the study targets of various groups of ...
Silvia Gherardi
doaj   +1 more source

Why human connection is the true metric of research success

open access: yesFEBS Open Bio, EarlyView.
Human‐centred mentorship can be shaped by mentor attributes, actions, intrinsic drive and career ambition. Drawing on reflections across Singapore and France, as well as workshop insights from FEBS‐IUBMB ENABLE 2024, this article shows that human‐centred mentorship creates the conditions for sustainable growth, well‐being and retention in research ...
Timothy Lin Yun Tan   +3 more
wiley   +1 more source

MOOC et Études Culturelles : que la créativité soit avec vous !

open access: yesMise au Point, 2015
This article exposes and analyzes two experiences of Mooc related to fan culture. The first one, « Understanding transmedia storytelling », led by Melanie Bourdaa for France Digital University, is devoted to these extensive narrative strategies in which ...
Mélanie Bourdaa et Laurence Allard
doaj   +1 more source

Home - About - Disclaimer - Privacy