Frontiers in Immunology, 2022 Liver disease is a significant contributor to morbidity and mortality in HIV-infected individuals, even during successful viral suppression with combination antiretroviral therapy (cART).
Bridget S. Fisher +10 more
doaj +1 more source
Divergent Annexin A1 expression in periphery and gut is associated with systemic immune activation and impaired gut immune response during SIV infection. [PDF]
, 2016 HIV-1 disease progression is paradoxically characterized by systemic chronic immune activation and gut mucosal immune dysfunction, which is not fully defined.
Dandekar, Satya +6 more
core +1 more source
Gut immune dysfunction through impaired innate pattern recognition receptor expression and gut microbiota dysbiosis in chronic SIV infection. [PDF]
, 2016 HIV targets the gut mucosa early in infection, causing immune and epithelial barrier dysfunction and disease progression. However, gut mucosal sensing and innate immune signaling through mucosal pattern recognition receptors (PRRs) during HIV infection ...
Bäumler, AJ +9 more
core +2 more sources
Dynamics of SIV-specific CXCR5+ CD8 T cells during chronic SIV infection [PDF]
Proceedings of the National Academy of Sciences, 2017 Significance Simian immunodeficiency virus (SIV)-specific follicular CD8 T cells represent a unique subset of antiviral CD8 T cells that rapidly expand during pathogenic SIV infection, localize within B-cell follicles, and contribute to control of chronic SIV replication.
Geetha H. Mylvaganam +13 more
openaire +4 more sources
Protection of rhesus macaques from SIV infection by immunization with different experimental SIV vaccines. [PDF]
, 1994 The immunogenicity and efficacy of an inactivated whole SIVmac (32H) preparation adjuvanted with muramyl dipeptide (SIV-MDP) and a gp120-enriched SIVmac (32H) ISCOM preparation (SIV-ISCOM), were compared by immunizing four rhesus macaques (Macaca mulatta)
Almond +36 more
core +7 more sources
Viruses, 2020 HIV/SIV-associated oral mucosal disease/dysfunction (HAOMD) (gingivitis/periodontitis/salivary adenitis) represents a major comorbidity affecting HIV patients on anti-retroviral therapy. Using a systems biology approach, we investigated molecular changes
Xavier Alvarez +3 more
doaj +1 more source
Vaccines, 2023 In the fall of 2022, the number of influenza-like illnesses (ILIs) and severe acute respiratory infections (SARIs) in Saudi Arabia had significantly increased compared with the corresponding period in previous years.
Saeed Mastour Alshahrani, Yousef Zahrani
doaj +1 more source
TIGIT Marks Exhausted T Cells, Correlates with Disease Progression, and Serves as a Target for Immune Restoration in HIV and SIV Infection. [PDF]
, 2016 HIV infection induces phenotypic and functional changes to CD8+ T cells defined by the coordinated upregulation of a series of negative checkpoint receptors that eventually result in T cell exhaustion and failure to control viral replication.
Abdel-Mohsen, Mohamed +20 more
core +3 more sources
Protection against highly pathogenic SIV by BCG-SIV recombinant priming and attenuated replicating vaccinia-SIV recombinant boosting [PDF]
Retrovirology, 2012 Methods Indian rhesus macaques were immunized with rBCG-SIV expressing SIV Gag, Env, or Rev-Tat-Nef (RTN) fusion proteins via subcutaneous injection, followed with two boosts with the Gag-, Env-, RT-, or RTN-expressing m8Δ by skin scarification. Eight weeks after the 2nd boost, macaques were challenged up to 5 times with a low dose of SIVmac251 by the ...
Sakawaki, H +11 more
openaire +3 more sources
Human Vaccines & Immunotherapeutics, 2018 HIV sequence diversity and the propensity of eliciting immunodominant responses targeting inessential variable regions are hurdles in the development of an effective AIDS vaccine.
Xintao Hu +9 more
doaj +1 more source