Results 71 to 80 of about 2,730,927 (298)

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Six Sigma Driven Enterprise Model Transformation

International Journal of Engineering Business Management, 2009
Enterprise architecture methods provide a structured system to understand enterprise activities. However, existing enterprise modelling methodologies take static views of the enterprise and do not naturally lead to a path of improvement during enterprise
Raymond Vella, Sekhar Chattopadhyay, John P.T. Mo   +2 more
doaj   +2 more sources

Usulan Perbaikan Kualitas Penggulungan Benang Nilon Dengan Menggunakan Metode Six Sigma di PT. XYZ

Jurnal Energi Dan Manufaktur, 2016
Abstrak: PT. XYZ merupakan perusahaan yang bergerak dibidang textil yang memproduksi benang jahit. Perusahaan selalu berusaha meningkatkan kualitas produknya dalam penanganan produk yang cacat yang terjadi pada proses produksi karena jumlah cacat yang ...
I Wayan Sukania, Iphov Kumala Sriwana, Edwin Suryajaya   +2 more
doaj  

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

A theoretical framework for exploring the effect of the Six Sigma management activities on corporate competitiveness

, 2011
Six Sigma has long been used as an effective way to restructure a company’s management process. While there are abundant case study literatures on Six Sigma, a theoretical framework that can logically advance the previous work into a higher level is ...
Lee, Kun-Chang, Choi, Bong, Li, Honglei
core  

Implementation of Six Sigma methodologies in service industry [PDF]

, 2021
LAUREA MAGISTRALEAttualmente le aziende si trovano ad affrontare un ambiente sempre più competitivo in cui la soddisfazione e la fedeltà dei clienti sono fattori determinanti per il successo di qualsiasi organizzazione.
Gopinath, Naveenkrishna, Ravichandran, Dhivya Bharathi   +1 more
core  

ACHIEVING COMPETITIVE ADVANTAGE THROUGH THE LEAN SIX SIGMA MODEL [PDF]

Analele Universităţii Constantin Brâncuşi din Târgu Jiu : Seria Economie
In light of the intricate and evolving market landscape induced by globalisation and the health crisis, companies must swiftly respond to the actions of their competitors.
ANDRISAN GABRIELA NICOLETA, MODREANU ANDRA   +1 more
doaj  

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

ANALISIS KECACATAN PRODUK AIR MINUM DALAM KEMASAN (AMDK) SEBAGAI UPAYA PERBAIKAN KUALITAS DENGAN METODE DMAIC

Spektrum Industri: Jurnal Ilmiah Pengetahuan dan Penerapan Teknik Industri, 2014
Produsen air minum dalam kemasan (AMDK) mengalami masalah kualitas yaitu dengan terdapatnya produk-produk cacat pada setiap produksi yang belum mencapai zero defect, terutama pada lini produksi kemasan gelas ukuran 240 ml yang paling banyak mengalami ...
Heri Wibowo, Emy Khikmawati
doaj  

The Process to Estimate Economical Benefits of Six Sigma Projects

Kvalita Inovácia Prosperita, 2013
This paper seeks to define the process for the continuous evaluation of the financial benefits during Six Sigma project life time. The financial criteria are critical success factors of a Six Sigma project.
Jan Kosina
doaj   +1 more source