Results 101 to 110 of about 13,337,459 (299)

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

FEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav, Bogdan I. Florea, Sebastian Geibel   +2 more
wiley   +1 more source

Practical considerations for optimal designs in clinical dose finding studies [PDF]

Determining an adequate dose level for a drug and, more broadly, characterizing its dose response relationship, are key objectives in the clinical development of any medicinal drug. If the dose is set too high, safety and tolerability problems are likely
Dette, Holger, Pinheiro, José, Bretz, Frank   +2 more
core  

Institutional clinical indication-based typical dose values of multiphasic abdominopelvic computed tomography examinations

Diagnostic and Interventional Radiology
PURPOSE: Our study aimed to obtain clinical indication-based typical dose values and size-specific dose estimates (SSDEs) for multiphasic abdominopelvic computed tomography (CT) examinations and to review our data with published diagnostic reference ...
Süleyman Filiz, Safiye Gürel, Kamil Gürel   +2 more
doaj   +1 more source

CAN THE SIZE-SPECIFIC DOSE ESTIMATE BE DERIVED FROM THE BODY MASS INDEX? A FEASIBILITY STUDY. [PDF]

Radiat Prot Dosimetry, 2022
Steiniger B, Klippel C, Teichgräber U, Reichenbach JR, Fiebich M.   +4 more
europepmc   +1 more source

Prospecting the protein design landscape

FEBS Letters, EarlyView.
This review outlines the current state of various protein design approaches. We discuss the current possibilities enabled by recently released tools, highlight future avenues to pursue in protein design, and underscore the crucial role of key databases and resources for successful protein design workflows.
Jakob R. Riccabona, Katharina T. Stonig, Jens Meiler, Clara T. Schoeder, Monica L. Fernández‐Quintero   +4 more
wiley   +1 more source

Validation of SSDE calculation in a modern CT scanner and correlation with effective dose

Scientific Reports
This study aims to validate the Size Specific Dose Estimate (SSDE) provided by a modern Computed Tomography (CT) scanner and investigate its correlation with effective dose (E).
Nicola Zancopè, Francesca De Monte, Erica Simeone, Angelo Giannone, Riccardo Lombardi, Alessandro Mele, Alessandra Zorz, Alessandro Di Paola, Francesco Causin, Marta Paiusco   +9 more
doaj   +1 more source

L‐aspartate oxidase provides new insights into fumarate reduction in anaerobic darkness in Synechocystis sp. PCC6803

FEBS Letters, EarlyView.
Synechocystis strains deficient in succinate dehydrogenase (SDH) secrete more succinate than the WT under dark anaerobic conditions, supporting that SDH then primarily acts as SDH, not as a fumarate reductase. L‐aspartate oxidase (Laspo) from Synechocystis is functional under anaerobic conditions, reducing fumarate to succinate.
Kateryna Kukil, Jeffrey A. Hawkes, Cecilia Blikstad, Pia Lindberg   +3 more
wiley   +1 more source

Estimation of radiation dose associated with bone SPECT/CT and establishing local diagnostic reference levels using size-specific dose estimate

Journal of Radiation Research and Applied Sciences, 2023
Faisal A. Alrehily, A. Alshamrani
semanticscholar   +1 more source

A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma

FEBS Letters, EarlyView.
Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos, Antonia Petropoulou, Alexandra Anastogianni, Angelina Bania, Vassilis Stamatakis, Argyris Alexiou, Chi‐Ping Day, Glenn Merlino, Katerina Grafanaki, Constantinos Stathopoulos   +9 more
wiley   +1 more source

Comparison of Size specific dose estimates (SSDE) and CTDIvol values in patients undergoing CT examinations of abdomen and pelvis

Radiography Open
Introduction: Computed Tomography Dose Index volume (CTDIvol) is a measure of radiation output of the CT scanner and does not represent patient dose.
Sweta Joshi, Sharma Paudel, Shanta Lall Shrestha, Surendra Maharjan   +3 more
doaj   +1 more source