Results 91 to 100 of about 13,337,459 (299)

Estimation of Dose-Response Functions and Optimal Doses with a Continuous Treatment [PDF]

This paper considers the continuous-treatment case and develops nonparametric estimators for the average dose-response function, the treatment level at which this function is maximized (location of the maximum), and the maximum value achieved by this ...
Carlos A. Flores
core  

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Evaluating Size-Specific Dose Estimate (SSDE) as an Estimate of Organ Doses Derived from Monte Carlo Simulations of CT Exams [PDF]

, 2019
INTRODUCTIONIn 2011, the American Association of Physicist in Medicine (AAPM) devised the Size-Specific Dose Estimate (SSDE) quantity in Report 204. SSDE is a dose metric that adjusts the commonly-reported CTDIvol metric to account for patient size. SSDE
Hardy, Anthony James
core   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

The Profile of Size-Specific Dose Estimate (SSDE) along the Longitudinal Axis in CT Using Tube Current Modulation (TCM)

, 2017
No abstract available."The Profile of Size-Specific Dose Estimate (SSDE) along the Longitudinal Axis in CT Using Tube Current Modulation (TCM)." with C. Anam. Information. Vol. 20 No. 1(B) October 2017.
Geoff Dougherty
core  

Using a Somatosensory Controller to Assess Body Size for Size-Specific Dose Estimates in Computed Tomography

, 2018
Computed tomography (CT) has been widely used in the healthcare environment. Presently, the radiation dose in CT is determined using the size-specific dose estimate (SSDE).
Ruo-Ping Han, Yan-Lin Liu, Jay Wu
core   +1 more source

Size‐specific dose estimates calculated using patient size measurements from scanned projection radiograph in high‐resolution chest computed tomography

Journal of Medical Radiation Sciences
Introduction Size‐specific dose estimates (SSDE) are used to assess patient‐specific radiation exposure in Computed Tomography (CT), complementing the volume CT dose index (CTDIvol).
Ajit Brindhaban
doaj   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Appraisal of radiation dose with 64-slice computed tomography perfusion in lung cancer patients with special reference to SSDE: An initial experience in a tertiary care hospital

Indian Journal of Radiology and Imaging, 2017
Context: Computed tomography perfusion (CTP) is an important functional tool for lung cancer. It is expected to deliver high radiation dose, making its accurate estimation important. Size-specific dose estimate (SSDE) is a new dose metric, which includes
Shuchi Bhatt, Ajai K Srivastava, Neha Meena, Shweta Thakur   +3 more
doaj   +1 more source

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

FEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança, Eline L. Jansen, Jorine M. Eeftens   +2 more
wiley   +1 more source