Results 81 to 90 of about 15,618,877 (244)
Scientific ReportsCT-guided interventions require balance between radiation dose and image quality. This study evaluates the impact of tube voltage and tube load on the contrast-to-noise ratio (CNR) across different patient sizes and target tissues. A modular multi-energy
Constantin Schareck +4 more
doaj +1 more source
Prospecting the protein design landscape
FEBS Letters, EarlyView.This review outlines the current state of various protein design approaches. We discuss the current possibilities enabled by recently released tools, highlight future avenues to pursue in protein design, and underscore the crucial role of key databases and resources for successful protein design workflows.
Jakob R. Riccabona +4 more
wiley +1 more source
Estimating size specific dose estimate from computed tomography radiograph localizer with radiation risk assessment. [PDF]
J Appl Clin Med Phys, 2023 Burton CS, Al-Ward S.
europepmc +1 more source
FEBS Letters, EarlyView.Synechocystis strains deficient in succinate dehydrogenase (SDH) secrete more succinate than the WT under dark anaerobic conditions, supporting that SDH then primarily acts as SDH, not as a fumarate reductase. L‐aspartate oxidase (Laspo) from Synechocystis is functional under anaerobic conditions, reducing fumarate to succinate.
Kateryna Kukil +3 more
wiley +1 more source
, 2018 The purpose of this study is to establish the relationship between the pixel value (I) of the CT localizer radiograph and water-equivalent thickness (tw) in a straightforward procedure.
Geoff Dougherty
core
Indian Journal of Radiology and Imaging, 2017 Context: Computed tomography perfusion (CTP) is an important functional tool for lung cancer. It is expected to deliver high radiation dose, making its accurate estimation important. Size-specific dose estimate (SSDE) is a new dose metric, which includes
Shuchi Bhatt +3 more
doaj +1 more source
CAN THE SIZE-SPECIFIC DOSE ESTIMATE BE DERIVED FROM THE BODY MASS INDEX? A FEASIBILITY STUDY. [PDF]
Radiat Prot Dosimetry, 2022 Steiniger B +4 more
europepmc +1 more source
A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma
FEBS Letters, EarlyView.Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos +9 more
wiley +1 more source
Practical considerations for optimal designs in clinical dose finding studies [PDF]
Determining an adequate dose level for a drug and, more broadly, characterizing its dose response relationship, are key objectives in the clinical development of any medicinal drug. If the dose is set too high, safety and tolerability problems are likely
Dette, Holger +2 more
core
A simple manual method to estimate water-equivalent diameter for calculating size-specific dose estimate in chest computed tomography. [PDF]
Br J Radiol, 2021 Mihailidis D, Tsapaki V, Tomara P.
europepmc +1 more source