Results 71 to 80 of about 15,618,877 (244)

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Volume Computed Tomography Dose Index (CTDIvol) and Size-Specific Dose Estimate (SSDE) for Tube Current Modulation (TCM) in CT Scanning

, 2018
Background: In the tube current modulation (TCM) technique, tube current is changed dynamically during the scanning process. To quantify the effect of a dynamic tube current, a distinct calculator is needed to estimate the CT output radiation dose in ...
Geoff Dougherty
core  

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

FEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança, Eline L. Jansen, Jorine M. Eeftens   +2 more
wiley   +1 more source

Estimation of Dose-Response Functions and Optimal Doses with a Continuous Treatment [PDF]

This paper considers the continuous-treatment case and develops nonparametric estimators for the average dose-response function, the treatment level at which this function is maximized (location of the maximum), and the maximum value achieved by this ...
Carlos A. Flores
core  

Size‐specific dose estimates calculated using patient size measurements from scanned projection radiograph in high‐resolution chest computed tomography

Journal of Medical Radiation Sciences
Introduction Size‐specific dose estimates (SSDE) are used to assess patient‐specific radiation exposure in Computed Tomography (CT), complementing the volume CT dose index (CTDIvol).
Ajit Brindhaban
doaj   +1 more source

Relationship between Water-equivalent Diameter, Computed Tomography Dose Indices, and Image Noise in Pediatric Head Computed Tomography Under Active and Inactive Tube Current Modulation

Journal of Medical Physics
Purpose: This study investigated the relationships among water-equivalent diameter (Dw), volume computed tomography dose index (CTDIvol), size-specific dose estimate (SSDE), and image noise in pediatric head computed tomography (CT) under active and ...
Evi Setiawati, Choirul Anam, Bella Diani Safitri, Much Azam, Qidir Maulana Binu Soesanto, Agus Margiantono   +5 more
doaj   +1 more source

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

FEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav, Bogdan I. Florea, Sebastian Geibel   +2 more
wiley   +1 more source