Results 101 to 110 of about 17,889,374 (275)
El presagio en la adaptación de Ruano de la Haza de Celestina en el siglo XXI
Celestinesca, 2019 Puede considerarse que la versión de Ruano de la Haza (2004) de Celestina (ca.1499/ca.1502) de Fernando de Rojas se trata de una adaptación para ser representada.
María Ángeles Ruiz Moneva
doaj +1 more source
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Antinomie dialettiche nel De magnanimitate di Giovanni Pontano
PeloroIl De magnanimitate di Giovanni Pontano, maestro riconosciuto dell’Umanesimo aragonese, si apre con un’articolata definizione della magnanimitas, virtù connaturata ai regnanti che corrisponde alla μεγαλοψυχία aristotelica.
Giuseppe Zeccato
doaj +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
«So scudo e lancia adoperare anch’io»: Marfisa donna e cavaliere
PeloroIl contributo intende studiare il personaggio di Marfisa nell’Inamoramento de Orlando di Matteo Maria Boiardo e nell’Orlando furioso di Ludovico Ariosto, con alcuni accenni alla Marphisa bizarra di Giovan Battista Dragoncino da Fano (1531).
Rosario Carbone
doaj +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Scientific ReportsThe aim of this study was to investigate the measurement of the incident angle of the main blood vessel, and the benefits of its integral with ultrasound malignant features of breast nodules for the assessment of breast malignancy based on BI-RADS.
Kailiang Chen, Size Wu
doaj +1 more source
Estimating the size of the European stimulus packages [PDF]
David Saha and Jakob von Weizsäcker present the latest breakdown of the fiscal stimuli in the 13 largest EU economies and compare the total European package for 2009 to the US stimulus package.
Jakob von Weizsäcker
core +1 more source
FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source