Results 61 to 70 of about 1,745,772 (291)

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

EFFECT OF INBREEDING ON THE PERFORMANCE OF LARGE WHITE YORKSHIRE SOWS [PDF]

Journal of Veterinary and Animal Sciences, 2004
Data relating to 130 sows, 19 boars from 400 farrowings spread over a period from 1984 to 1992 were utilized to study genetic and non-genetic effects on variation of litter size at birth and litter size at weaning.
M. Vasundhara devi, M.G. Govindaiah, H.N.N. Murthy, S.B. Krishnappa, Shrikant Joshi   +4 more
doaj  

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

Snus in pregnancy and infant birth size: a mother–child birth cohort study

ERJ Open Research, 2019
Rationale While recent studies show that maternal use of snus during pregnancy is increasing, the potential effects on infant birth size is less investigated, with conflicting results.
Ina Kreyberg, Katarina Hilde, Karen Eline S. Bains, Kai-Håkon Carlsen, Berit Granum, Guttorm Haugen, Gunilla Hedlin, Christine M. Jonassen, Live S. Nordhagen, Björn Nordlund, Corina S. Rueegg, Katrine D. Sjøborg, Håvard O. Skjerven, Anne C. Staff, Riyas Vettukattil, Karin C. Lødrup Carlsen, the PreventADALL Study Group   +16 more
doaj   +1 more source

The impact of dietary diversity and seasonality in food availability on the quantile distribution of birth size among pregnant women in rural Malawi – a cross-sectional study

BMC Pregnancy and Childbirth, 2022
Background Dietary diversity scores can be used as a proxy for dietary intakes and for assessment of nutrient adequacy. Studies from low-resource settings have found maternal dietary diversity scores to be associated with neonatal birth size.
Katrine G. Hjertholm, Gerd Holmboe-Ottesen, Ibrahimu Mdala, Zumin Shi, Per O. Iversen   +4 more
doaj   +1 more source

Reproductive performance in cervical and postcervical artificial insemination (PCAI) with liquid boar semen in Gunghroo × Hampshire crossbreed pig in Nagaland

Indian Journal of Animal Sciences, 2020
Genetic advancement for the modern swine industry is primarily accomplished through the use of reproductive biotechnology, mainly artificial insemination (AI).
MAHAK SINGH, R TALIMOA MOLLIER, P H ROMEN SHARMA, J K CHAUDHARY   +3 more
doaj   +1 more source

Determinant factors of under-five mortality in Southern Nations, Nationalities and People’s region (SNNPR), Ethiopia

Italian Journal of Pediatrics, 2021
Background Child mortality is a key indicator of the performance of the health system of a nation. Impressive progress in the reduction of under-five mortality has been made in Ethiopia.
Gizachew Gobebo
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Violence during pregnancy: Determinants and association with small size of baby at birth [PDF]

Journal of Sharif Medical & Dental College, 2016
Objective: Intimate partner violence (IPV) is a global health concern. The aim of this study was to determine whether there is an association between IPV and the size of child at the time of birth. Methodology: A systematic data collected from Pakistan
Muhammad Anwar Sulehri, Younas Mehrose, Madiha Anwar Sulehri, Rabia Anwar   +3 more
doaj