Results 51 to 60 of about 994,709 (302)

Complex coordination of cell plasticity by a PGC-1α-controlled transcriptional network in skeletal muscle [PDF]

, 2015
Skeletal muscle cells exhibit an enormous plastic capacity in order to adapt to external stimuli. Even though our overall understanding of the molecular mechanisms that underlie phenotypic changes in skeletal muscle cells remains poor, several factors ...
Agrawal, Aitchison, Altschul, Andersson, Blows, Blows, Bonduriansky, Brooks, Chenoweth, Chenoweth, Chung, Connallon, Coyne, Dallerac, Darwin, Doerge, Eyre-Walker, Fang, Ferreira, Ferveur, Fiumera, Frentiu, Gibbs, Gosden, Haldane, Hereford, Hine, Hine, Hine, Howard, Howard, Johnston, Kennington, Kingsolver, Kistler, Labeur, Lande, Long, Magwire, Mousseau, Park, Rako, Reinhart, Ritchie, Roff, Rundle, Sall, Siller, Swanson, Wagner, Weeks, Wilkinson, Zhang   +52 more
core   +4 more sources

The associations of sedentary time and breaks in sedentary time with 24-hour glycaemic control in type 2 diabetes [PDF]

, 2018
The aim of this study was to investigate the associations of accelerometer-assessed sedentary time and breaks in sedentary time with 24-h events and duration of hypoglycaemia (7.8 mmol/l) and above target glucose (>9 mmol/l).
Assah, Bailey, Bergouignan, Bonakdaran, Bond, Bonora, Butkowski, Chastin, Chastin, Cheyette, DeFronzo, Dempsey, Dunstan, Duvivier, Edwardson, Franks, Fritschi, Giacco, Godfrey, Gonzalez, Graham Thomas, Grant, Grant, Hartz, Hawari, Hay, Healy, Healy, Healy, Helmerhorst, Home, International Diabetes Federation, International Diabetes Federation Guideline Development Group, Kozey-Keadle, Mailey, Marshall, Morgan, Paing, Pulsford, Razavi Nematollahi, Reid, Richter, Sardinha, Sinacore, Tancredi, Tremblay, Tremblay, Turner, Uberos Fernández, Van Dalem, van der Berg, Wilmot   +51 more
core   +3 more sources

Impact of exercise-nutritional state interactions in patients with type 2 diabetes

, 2020
Introduction This study examines the role of nutritional status during exercise training in patients with type 2 diabetes mellitus by investigating the effect of endurance-type exercise training in the fasted versus the fed state on clinical outcome ...
Calders, Patrick, Celie, Bert, Dendale, Paul, Hansen, Dominique, Lapauw, Bruno, Stevens, An, van Loon, Luc JC, Vandenabeele, Frank, Verboven, Kenneth, Wens, Inez   +9 more
core   +1 more source

Spontaneous physical activity down-regulates Pax7 in cancer cachexia [PDF]

, 2015
Emerging evidence suggests that the muscle microenvironment plays a prominent role in cancer cachexia. We recently showed that NF-kB - induced Pax7 overexpression impairs the myogenic potential of muscle precursors in cachectic mice, suggesting that ...
Adamo, Sergio, Annibali, Daniela, Aulino, Paola, Barteri, Fabio, Berardi, Emanuele, Coletti, Dario, Moresi, Viviana, Pigna, Eva   +7 more
core   +5 more sources

Risk of skeletal related events among elderly prostate cancer patients by site of metastasis at diagnosis

Cancer Medicine, 2016
The purpose of this study was to estimate the risk of developing skeletal‐related events (SREs) based on site of metastasis at diagnosis and identify other predictors of developing SREs among metastatic prostate cancer patients.
Arif Hussain, Abdalla Aly, C. Daniel Mullins, Yi Qian, Jorge Arellano, Eberechukwu Onukwugha   +5 more
doaj   +1 more source

High cycling cadence reduces carbohydrate oxidation at given low intensity metabolic rate [PDF]

, 2014
Cycling cadence (RPM)-related differences in blood lactate concentration (BLC) increase with increasing exercise intensity, whilst corresponding divergences in oxygen uptake (VO2) and carbon dioxde production (VCO2) decrease.
Alkhatib, Ahmad, Beneke, Ralph
core   +6 more sources

Skeletal-Related Events in Patients With Multiple Myeloma: A Comprehensive Retrospective Cohort Study

Journal of Korean medical science
Background Multiple myeloma (MM) patients are at risk of skeletal-related events (SREs) like spinal cord compression, pathologic fractures, bone surgery, and radiation to bone. Real-world data regarding SREs in MM are limited.
Ji Yun Lee, Ju-Hyun Lee, J. Seo, Minsu Kang, E. Jung, Sang-A Kim, K. J. Suh, Ji-Won Kim, Se Hyun Kim, Jeong-Ok Lee, Jin Won Kim, Yu Jung Kim, Keun-Wook Lee, Jeehyoung Kim, Jong Seok Lee, Soo-Mee Bang   +15 more
semanticscholar   +1 more source

Current comprehensive understanding of denosumab (the RANKL neutralizing antibody) in the treatment of bone metastasis of malignant tumors, including pharmacological mechanism and clinical trials

Frontiers in Oncology, 2023
Denosumab, a fully humanized monoclonal neutralizing antibody, inhibits activation of the RANK/RANKL/OPG signaling pathway through competitive binding with RANKL, thereby inhibiting osteoclast-mediated bone resorption.
Junjie Lu, Desheng Hu, Yan Zhang, Chen Ma, Lin Shen, Bo Shuai   +5 more
doaj   +1 more source

Arterial dysgenesis and limb defects : Clinical and experimental examples [PDF]

, 2017
Acknowledgements This article is dedicated to Dr David S. Packard Jr. With thanks to Dr John DeSesso, Dr Lewis B. Holmes, Dr Mark Levinsohn, Dr David S.
Hootnick, David R., Vargesson, Neil
core   +1 more source

Are bone targeted agents still useful in times of immunotherapy? The SAKK 80/19 BTA pilot study

Bone Reports
Background: Patients with bone metastases from solid tumors often have additional treatment with bone targeted agents (BTAs) to avoid symptomatic skeletal events (SSEs) such as clinically significant pathological fracture leading toradiation therapy or ...
Michael Mark, Alfonso Rojas Mora, Thomas Winder, Anastasios Stathis, Andreas Jakob, Gisela Müller, Stefanie Hayoz, Patrick Reimann, Ulf Petrausch, Roger von Moos   +9 more
doaj   +1 more source