Results 41 to 50 of about 12,105,273 (242)

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Skeletal-related events (SREs) are common in patients with bone metastasis from renal cell carcinoma (N = 398).

, 2013
Skeletal-related events (SREs) are common in patients with bone metastasis from renal cell carcinoma (N = 398).
Saverio Cinieri (477380), Sergio Bracarda (503257), Nicola Silvestris (477360), Giuseppe Badalamenti (503251), Sandro Barni (477365), Giuseppe Tonini (222938), Rossana Berardi (477376), Vincenzo Adamo (503254), Calogero Mazzara (503245), Giacomo Carteni (5657380), Andrea Fontana (152789), Francesca Maria Tanca (503253), Roberto Sabbatini (503255), Maria Antonietta Satolli (477367), Evaristo Maiello (477372), Daniele Santini (222870), Matteo Santoni (503249), Camillo Porta (133354), Stefano Luzi Fedeli (503252), Gaetano Lanzetta (503247), Alfredo Berruti (503246), Cinzia Ortega (222881), Giuseppe Procopio (503244), Toni Ibrahim (477361), Davide Ottaviani (23156), Elena Collovà (503250), Vladimir Virzì (503248), Antonio Russo (168018), Alessandra Felici (503256), Bruno Vincenzi (82033)   +29 more
core   +1 more source

Current approaches to bone-targeted therapy in genitourinary malignancies

Therapeutic Advances in Urology, 2012
Bone metastases in patients with genitourinary cancers are associated with increased risk for skeletal-related events including pathologic fractures, spinal cord compression, and the requirement for surgery or palliative radiotherapy to bone.
Peter F. Mulders
doaj   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

Incidence of skeletal-related events (SREs) in patients with bone metastases from renal cell carcinoma (N = 398).

, 2013
Incidence of skeletal-related events (SREs) in patients with bone metastases from renal cell carcinoma (N = 398).
Saverio Cinieri (477380), Sergio Bracarda (503257), Nicola Silvestris (477360), Giuseppe Badalamenti (503251), Sandro Barni (477365), Giuseppe Tonini (222938), Rossana Berardi (477376), Vincenzo Adamo (503254), Calogero Mazzara (503245), Giacomo Carteni (5657380), Andrea Fontana (152789), Francesca Maria Tanca (503253), Roberto Sabbatini (503255), Maria Antonietta Satolli (477367), Evaristo Maiello (477372), Daniele Santini (222870), Matteo Santoni (503249), Camillo Porta (133354), Stefano Luzi Fedeli (503252), Gaetano Lanzetta (503247), Alfredo Berruti (503246), Cinzia Ortega (222881), Giuseppe Procopio (503244), Toni Ibrahim (477361), Davide Ottaviani (23156), Elena Collovà (503250), Vladimir Virzì (503248), Antonio Russo (168018), Alessandra Felici (503256), Bruno Vincenzi (82033)   +29 more
core   +1 more source

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

FEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise, Tiziano Mazza, Raffaella Scanga, Lara Console, Michele Galluccio, Cesare Indiveri   +5 more
wiley   +1 more source

Nitric oxide synthase in skeletal muscle fibres of patients with type 2 diabetes [PDF]

, 2012
Muscle-derived nitric oxide (NO) mediates fundamental physiological actions on skeletal muscle including glucose uptake into muscle cells. Recently, we have shown that the altered glucose metabolism in skeletal muscle of patients with type 2 diabetes ...
Karla Punkt, Volker Adams, Katharina Kandt, Matthias Blueher, Andreas Oberbach, Igor Buchwalow   +5 more
core  

Statins may decrease skeletal-related events in breast cancer patients with bone metastases

, 2006
Metastasis to the skeleton frequently occurs in breast carcinoma patients resulting in different skeletal-related events including pain, hypercatcemia, pathological fracture, and spinal cord or nerve root compression.
Bulut, Nilufer, Altundag, Kadri, Harputluoglu, Hakan, Dincer, Murat   +3 more
core   +1 more source

Geometry of skeletal structures and symmetry sets [PDF]

, 2012
In this thesis we study the geometry of symmetry sets and skeletal structures. The relationship between a symmetry point (skeletal point) and the associated midlocus point is studied and the impact of the singularity of the radius function on this ...
Alghanemi, Azeb Zain Jafar
core   +5 more sources

Atypical tibial fracture in breast cancer patient with bone metastasis receiving denosumab therapy: a case report and review of the literature

Journal of Medical Case Reports, 2023
Background Denosumab therapy is often used to reduce skeletal-related events in metastatic bone disease. On the other hand, there have been some instances of atypical femoral fracture in patients with metastatic bone disease treated with denosumab.
Yohei Yanagisawa, Hidefumi Suzuki, Hisanori Gamada, Masashi Yamazaki   +3 more
doaj   +1 more source