Results 41 to 50 of about 383,968 (297)

High cycling cadence reduces carbohydrate oxidation at given low intensity metabolic rate [PDF]

, 2014
Cycling cadence (RPM)-related differences in blood lactate concentration (BLC) increase with increasing exercise intensity, whilst corresponding divergences in oxygen uptake (VO2) and carbon dioxde production (VCO2) decrease.
Alkhatib, Ahmad, Beneke, Ralph
core   +6 more sources

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Oral ibandronate for the treatment of metastatic bone disease in breast cancer: efficacy and safety results from a randomized, double-blind, placebo-controlled trial [PDF]

, 2017
Background: We report the first results of a randomized trial assessing a new oral aminobisphosphonate, ibandronate, in patients with bone metastases from breast cancer. Patients and methods: Patients (n = 435) received placebo, or oral ibandronate 20 mg
Apffelstaedt, J., Bergstrom, B., Budde, M., Lazarev, A., Lichinitzer, M., MacLachlan, S. A., Tripathy, D.   +6 more
core  

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Factors Associated with Discharge Destination in Patients with Bone Metastases

Medicina
Background and Objectives: The discharge destination of patients with advanced cancer correlates with their quality of life. Patients with bone metastases often undergo lifestyle changes owing to pain and activity limitations.
Hanako Himematsu, Yukiyo Shimizu, Tami Yuhara, Kenta Hiasa, Masashi Yamazaki, Yasushi Hada   +5 more
doaj   +1 more source

Atypical tibial fracture in breast cancer patient with bone metastasis receiving denosumab therapy: a case report and review of the literature

Journal of Medical Case Reports, 2023
Background Denosumab therapy is often used to reduce skeletal-related events in metastatic bone disease. On the other hand, there have been some instances of atypical femoral fracture in patients with metastatic bone disease treated with denosumab.
Yohei Yanagisawa, Hidefumi Suzuki, Hisanori Gamada, Masashi Yamazaki   +3 more
doaj   +1 more source

The prevalence and risks of injury for masters athletes : current findings [PDF]

, 2015
textRegular physical activity and exercise are important clinical tools that can be used to improve our health. This is especially true due to the prolonged lifespan of the average adult and the declines in physical function that are attributed to ...
Baker, Jeffrey Robinson
core   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Current approaches to bone-targeted therapy in genitourinary malignancies

Therapeutic Advances in Urology, 2012
Bone metastases in patients with genitourinary cancers are associated with increased risk for skeletal-related events including pathologic fractures, spinal cord compression, and the requirement for surgery or palliative radiotherapy to bone.
Peter F. Mulders
doaj   +1 more source

The pattern of bone involvement, management, and outcomes in patients with nonsmall cell lung cancer: A retrospective study

Annals of Thoracic Medicine, 2018
CONTEXT AND AIM: The skeleton is a frequent site for metastasis in patients with breast, lung, and prostate cancer. Bone metastasis compromises skeletal integrity leading to skeletal-related events (SREs).
Abdulrahman M Jazieh, Thuraya S AlSumai, Yosra Z Ali, Nagham R Sheblaq, Mohammad Alkaiyat   +4 more
doaj   +1 more source