Results 1 to 10 of about 193,078 (253)

Preventing Skeletal-Related Events in Newly Diagnosed Multiple Myeloma [PDF]

Cells
Despite the increasing number of novel therapies to treat newly diagnosed multiple myeloma (NDMM), preventing skeletal-related events (SREs) remains a challenge.
Benjamin Massat, Patrick Stiff, Fatema Esmail, Estefania Gauto-Mariotti, Patrick Hagen   +4 more
doaj   +5 more sources

Experience with denosumab (XGEVA®) for prevention of skeletal-related events in the 10 years after approval [PDF]

Journal of Bone Oncology, 2022
Skeletal-related events (SREs) are complications of bone metastases and carry a significant patient and economic burden. Denosumab is a receptor activator of nuclear factor-κB ligand (RANKL) inhibitor approved for SRE prevention in patients with multiple
Benoit Cadieux, Robert Coleman, Pegah Jafarinasabian, Allan Lipton, Robert Z. Orlowski, Fred Saad, Giorgio V. Scagliotti, Kazuyuki Shimizu, Alison Stopeck   +8 more
doaj   +4 more sources

The importance of retaining physical functions to prevent skeletal‐related events in multiple myeloma patients with bone disease [PDF]

eJHaem, 2022
This study was undertaken to identify baseline conditions and triggering factors for skeletal‐related events (SRE) in multiple myeloma (MM) patients treated with denosumab.
Hirokazu Miki, Shingen Nakamura, Masahiro Oura, Masafumi Nakamura, Ryohei Sumitani, Kimiko Sogabe, Mamiko Takahashi, Tomoko Maruhashi, Takeshi Harada, Shiro Fujii, Hirofumi Hamano, Masateru Kondo, Naoto Okada, Itsuro Endo, Masahiro Abe   +14 more
doaj   +2 more sources

Circulating tumor cells predict early skeletal-related events in patients with bone metastases from breast cancer [PDF]

The Journal of Liquid Biopsy
Background: Bone metastases and following skeletal-related events (SREs) are frequent in metastatic breast cancer (MBC) and are a major cause of disability.
S. Grisanti, F. Consoli, G. Ippolito, R. Pedersini, V. Amoroso, D. Cosentini, G. Scartabellati, L. Moretti, G. Schivardi, LC Ammoni, A. Baggi, A. Turla, W. Vermi, C. Almici, A. Berruti, M. Laganà   +15 more
doaj   +2 more sources

Plasma biomarkers of immune regulation and senescence are associated with incident skeletal-related events in people with HIV: a case-cohort study [PDF]

Immunity & Ageing
Background Persistent immune dysregulation in people with HIV (PWH) on antiretroviral therapy (ART) contributes to an increased risk of skeletal-related events (SREs), serving as a critical paradigm for understanding accelerated aging and age-related ...
Carlos Pita-Martínez, Marta Rava, Ana Virseda-Berdices, Isidoro Martínez, Santiago Moreno, Carmen Elena Gómez Rodríguez, Carlos Armiñanzas, Álvaro Mena de Cea, Laura Gisbert Pérez, Rafael Rodríguez-Rosado, María Ángeles Jiménez-Sousa, Salvador Resino, Rubén Martín-Escolano, CoRIS cohort   +13 more
doaj   +2 more sources

Incidence, Risk Factors, and Survival of Bone Metastases and Skeletal-Related Events in Melanoma Patients: A Systematic Review and Quality Assessment of 29 Studies [PDF]

Journal of Bone Oncology
Background: Skeletal metastases make up 17% of all metastases from advanced-stage melanoma. Bone metastases are associated with increased morbidity and mortality and decreased quality of life due to their association with skeletal-related events (SREs ...
Michelle R. Shimizu, Olaf N. van de Langerijt, Daniel Torres, Tom M de Groot, Olivier Q. Groot   +4 more
doaj   +2 more sources

Clinicopathologic characteristics, metastasis-free survival, and skeletal-related events in 628 patients with skeletal metastases in a tertiary orthopedic and trauma center [PDF]

World Journal of Surgical Oncology, 2021
Background Skeletal-related events (SREs) due to bone metastases (BM) significantly impact the morbidity and mortality of cancer patients. The present study sought to investigate clinicopathological characteristics, metastasis-free survival (MFS), and ...
Georg Herget, Babak Saravi, Eugenia Schwarzkopf, Mara Wigand, Norbert Südkamp, Hagen Schmal, Markus Uhl, Gernot Lang   +7 more
doaj   +2 more sources

Comparative Analyses of Two Established Scores to Assess the Stability of Spinal Bone Metastases Before and After Palliative Radiotherapy

Frontiers in Oncology, 2021
Background and PurposeTo compare two validated spinal instability scores regarding the stabilizing effects and skeletal-related events (SREs) of palliative radiotherapy (RT) in patients with spinal bone metastases (SBM).Materials and MethodsTwo hundred ...
Tilman Bostel, Tilman Bostel, Sati Akbaba, Sati Akbaba, Daniel Wollschläger, Tristan Klodt, Tristan Klodt, Laura Oebel, Laura Oebel, Arnulf Mayer, Arnulf Mayer, Sophia Drabke, Sophia Drabke, Tanja Sprave, Tanja Sprave, Jürgen Debus, Jürgen Debus, Robert Förster, Harald Rief, Alexander Rühle, Alexander Rühle, Anca-Ligia Grosu, Anca-Ligia Grosu, Heinz Schmidberger, Heinz Schmidberger, Nils H. Nicolay, Nils H. Nicolay   +26 more
doaj   +1 more source

Comparison of denosumab and zoledronic acid for the treatment of solid tumors and multiple myeloma with bone metastasis: a systematic review and meta-analysis based on randomized controlled trials

Journal of Orthopaedic Surgery and Research, 2021
Objective To compare the efficacy and safety between denosumab and zoledronic acid for advanced cancer with bone metastasis. Methods MEDLINE, EMBASE, and the Cochrane library databases were searched for randomized controlled trials up to December 2020 ...
Lianghai Jiang, Xianghua Cui, Haoning Ma, Xiangsheng Tang   +3 more
doaj   +1 more source

Complications of bone metastases from malignant melanoma

Journal of Bone Oncology, 2017
Introduction: Metastatic bone disease (MBD) carries significant morbidity for patients with cancer. MBD from malignant melanoma (MM) is understudied. We examined the characteristics, morbidity, management and outcome of MBD in patients with MM.
Jamal Zekri, Maria Marples, Dominic Taylor, Kiran Kandukurti, Lucy McParland, Janet E. Brown   +5 more
doaj   +1 more source