Results 41 to 50 of about 658,097 (269)
, 2008 Shape Descriptors are compact and expressive representations of objects suitable for solving problems like recognition, classification, or retrieval of shapes, tasks that are computationally expensive if performed on huge data sets. Skeletal structures are a particular class of shape descriptors, which attempt to quantify shapes in ways that agree with
Biasotti S +9 more
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Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Donald School Journal of Ultrasound in Obstetrics and Gynecology, 2011 ABSTRACT The word dysplasia originates from the ancient Greek words dys (anomalous) and plasia (formation). Skeletal dysplasia (SD) is a heterogeneous group of congenital anomalies characterized by abnormalities in the development of bone and cartilage tissues.
Antsaklis, A., Anastasakis, E.
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Welcome to Skeletal Muscle [PDF]
Skeletal Muscle, 2011 Over the past decade or two, cellular signaling and molecular genetics have combined to allow for a tremendous increase in the understanding of fundamental processes that are distinct to skeletal muscle: the genes that initiate its differentiation from progenitor cells and which establish its identity; pathways that are responsible for its hypertrophy ...
Glass David J +2 more
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Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source
Porcupine inhibition is a promising pharmacological treatment for severe sclerosteosis pathologies
Bone ResearchSclerosteosis, an ultra-rare disorder characterised by high bone mass (HBM) and skeletal overgrowth, leads to facial paralysis, hearing loss and raised intracranial pressure, which is currently managed only through high-risk surgery.
Timothy J. Dreyer +7 more
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Faunal Remains from Shikarpur, a Harappan Site in Gujarat, India [PDF]
Iranian Journal of Archaeological Studies, 2011 This paper deals with the preliminary observations of the analysis conducted on the faunal remains unearthed at thesite of Shikarpur. A single trench ES4 was selected as a research sample from the excavation conducted by theDepartment of Archaeology and ...
Pramod Joglekar, Pankaj Goyal
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Molecular Oncology, EarlyView.CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak +10 more
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Stem Cell Research & Therapy, 2018 Background Chondrogenic mesenchymal stem cells (MSCs) have not yet been used to address the clinical demands of large osteochondral joint surface defects.
L. F. Mendes +6 more
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FEBS Open Bio, EarlyView.Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn +4 more
wiley +1 more source