Results 71 to 80 of about 973,362 (309)

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

Skeletal organoids.

Biomaterials translational
The skeletal system, composed of bones, muscles, joints, ligaments, and tendons, serves as the foundation for maintaining human posture, mobility, and overall biomechanical functionality. However, with ageing, chronic overuse, and acute injuries, conditions such as osteoarthritis, intervertebral disc degeneration, muscle atrophy, and ligament or tendon
Zhang, Chen, Jing, Yingying, Wang, Jianhua, Xia, Zhidao, Lai, Yuxiao, Bai, Long, Su, Jiacan   +6 more
openaire   +2 more sources

Functional crosstalk of PGC-1 coactivators and inflammation in skeletal muscle pathophysiology [PDF]

, 2014
Skeletal muscle is an organ involved in whole body movement and energy metabolism with the ability to dynamically adapt to different states of (dis-)use.
Handschin, Christoph, Eisele, Petra S.
core   +1 more source

Porcupine inhibition is a promising pharmacological treatment for severe sclerosteosis pathologies

Bone Research
Sclerosteosis, an ultra-rare disorder characterised by high bone mass (HBM) and skeletal overgrowth, leads to facial paralysis, hearing loss and raised intracranial pressure, which is currently managed only through high-risk surgery.
Timothy J. Dreyer, Jacob A. C. Keen, Leah M. Wells, Mark Hopkinson, Isabel R. Orriss, Gill Holdsworth, Andrew A. Pitsillides, Scott J. Roberts   +7 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Multiple myeloma: imaging evaluation of skeletal disease

Journal of Community Hospital Internal Medicine Perspectives, 2013
This patient is a 56-year-old woman with a history of IGG κ multiple myeloma diagnosed 15 years prior to admission. She had widespread lytic bone lesions and pathological fractures, which remarkably had not been accompanied by significant pain ...
Carlton Sexton, Candice Crichlow
doaj   +1 more source

Advancing osteochondral tissue engineering: bone morphogenetic protein, transforming growth factor, and fibroblast growth factor signaling drive ordered differentiation of periosteal cells resulting in stable cartilage and bone formation in vivo

Stem Cell Research & Therapy, 2018
Background Chondrogenic mesenchymal stem cells (MSCs) have not yet been used to address the clinical demands of large osteochondral joint surface defects.
L. F. Mendes, H. Katagiri, W. L. Tam, Y. C. Chai, L. Geris, S. J. Roberts, F. P. Luyten   +6 more
doaj   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Skeletal muscle fiber-type switching, exercise intolerance, and myopathy in PGC-1alpha muscle-specific knock-out animals. [PDF]

, 2007
The transcriptional coactivator peroxisome proliferator-activated receptor gamma coactivator 1alpha (PGC-1alpha) is a key integrator of neuromuscular activity in skeletal muscle.
Handschin, Christoph, Li, P., Handschin, C., Lebrasseur, N. K., Li, Ping, Spiegelman, Bruce M, Maratos-Flier, E., Lebrasseur, Nathan K, Liu, Fenfen, Chin, Sherry, Maratos-Flier, Eleftheria, Spiegelman, B. M., Yan, Zhen, Yan, Z., Chin, S., Liu, F.   +15 more
core   +1 more source

Skeletal and Dental Effects of Forsus Fatigue Resistance Device Versus Twin Block Appliance for Class II Malocclusion Treatment in Growing Patients: A Systematic Review

Clinical and Experimental Dental Research
Objective This study systematically searched the literature and assessed the available evidence to compare the efficacy of Forsus Fatigue Resistance Device (FRD) versus Twin Block Appliance (TBA) in treating class II malocclusion.
Bahaa Aldeen Jeha, Rania Haddad
doaj   +1 more source